Seizures are a common neurologic consequence of various etiologies in the end-stage cancer patient. Because dying cancer patients and their families are often coping with new challenges daily, any intervention that can prevent further patient or family discomfort should be implemented. The purpose of this study was to evaluate four pharmacy interventions aimed at improving nursing care to cancer patients at a facility for the terminally ill. The four interventions were development of a seizure risk factor assessment toll, assembly or availability of a diazepam seizure kit, nursing education via in-service training, and development of a manual for nursing stations. Successful implementation of this project indicated that nurses perceived an empowerment in improving quality of life of their patients.
Carincross JG, Posner JB: Neurologic complications of systemic cancer. In Yarbro JW, Bornstein RD (eds.): Oncologic Emergencies. New York: Grune and Stratton, 1981.
2.
Gucalp R, Dutcher J: Oncologic emergencies. In Isselbacker KR, Braunwald E, Wilson JD, et al. (eds.): Harrison’s Principles of Internal Medicine. 14th Ed.New York: McGraw-Hill, 1998: 627-634.
3.
Kriel RL, Cloyd JC, Hadsall RS, et al.: Home use of rectal diazepam for cluster and prolonged seizures: Efficacy, adverse reactions, quality of life, and cost analysis. Pediatr Neurol. 1991: 7(1): 13-17.
4.
van Oosterhout AG, van de Pol M, ten Velde GP, Twijnstra A: Neurologic disorders in 203 consecutive patients with small cell lung cancer: Results of a longitudinal study. Cancer. 1996; 77(8): 1434-1441.
Sneed PK, Larson DA, Wara WM: Radiotherapy for cerebral metastases. Neurosurg Clin North Am. 1996; 7(3): 505-515.
7.
Chalifoux R, Elisevich K: Effect of ionizing radiation on partial seizures attributable to malignant cerebral tumors. Stereotact Funct Neurosurg. 1996-1997; 67(3-4): 169-182.
8.
Arita K, Kurisu K, Iida K, et al.: Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hematoma: Case report. J Neurosurg. 1998; 89(4): 645-648.
9.
Fuller GNKaba SE, Ginsberg LE, et al.: Late sequelae of treated pleomorphic xanthoastrocytoma: Malignant brain stem astrocytoma occurring 15 years after radiation therapy. J Neurooncol. 1997; 32(1): 57-61.
10.
de la Camara R, Tomas JF, Figuera A, et al.: High dose busulfan and seizures. Bone Marrow Transplant. 1991; 7(5): 363-364.
11.
Merimsky O, Reider-Groswasser I, Wigler N, et al.: Encephalopathy in fosfamide-treated patients. Acta Neurol Scand. 1992: 86(5): 521-525.
12.
Zarama M, Abraham PA: Drug induced renal disease. In DiPiro JT, et al. (eds.): Pharmacotherapy: A Pathophysiologic Approach. 3rd Ed.Norwalk, CT: Appleton and Lange, 1997: pp. 1007-1025.
13.
Gorman DJ, Kefford R, Stuart-Harris R.Focal encephalopathy after cisplatin therapy. Medical J Austral. 1989; 150(7): 399-401.
14.
Alldredge BK: Drug-induced seizures: Controversies in their identification and management. Pharmacotherapy. 1997; 17(5): 857-860.
15.
Alldredge BK: Drug-induced seizures. Epilepsy II. 1998; 12(1): 85-95.
16.
Stevens JR, Denney D, Szot P: Kindling with clozapine: Behavioral and molecular consequences. Epilepsy Research. 1996; 26(1): 295-304.
17.
Wong MC, Suite ND, Labar DR: Seizures in human immunodeficiency virus infection. Arch Neurol. 1990; 47(6): 640-642.
18.
Pieretti S, DiGiannuario A, Loizzo A, et al.: Dexamethasone prevents epileptiform activity induced by morphine in in-vivo and in-vitro experiments. J Pharmacol Exp Ther. 1992; 263(2): 830-839.
19.
Duport S, Stoppini L, Correges P: Electrophysiological approach of the antiepileptic effect of dexamethasone on hippocampal slice culture using a multirecording system: The physiocard. Life Sci. 1997; 60(17): PL251-PL256.
20.
Kubo M, Azuma E, Arai S, et al.: Transient encephalopathy following a single exposure of high-dose methotrexate in a child with acute lymphoblastic leukemia. Pediatr Hematol Oncol. 1992; 9(2): 157-165.
21.
Ch’ien LT, Aur RJ, Verzosa MS, et al.: Progression of methotrexate-induced leukoencephalopathy in children with leukemia. Med Pediatr Oncol. 1981; 9(2): 133-141.
22.
Priest JR, Ramsay NK, Steinherz PG, et al.: A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia. J Pediatr. 1982; 100(6): 984-989.
23.
Gilbert MR, Armstrong TS: Management of seizures in the adult patient with cancer. Cancer Pract. 1995; 3(3): 143-149.
