Purpose: The study examined the psychometric properties of the Greek posttraumatic growth inventory (PTGI) among healthcare workers and general population during the COVID-19 pandemic. Methods: The Greek versions of the PTGI, the Brief COPE, and the Brief Resilience scale were administered to 2163 participants from the general population and 1837 healthcare workers. Results: The five-factor structure was tested separately in the two samples and presented a comparable good fit to the data. Then it was tested in the combined sample against the single-factor structure and the five-factor structure showed a slightly better fit to the data. The PTGI showed good reliability (Cronbach's alpha, composite reliability, inter-item correlations, corrected item-total correlations, and scale-total correlations), convergent validity (AVE values and interscale correlations), discriminant validity (HTMT), and concurrent validity (correlation between PTGI-Spiritual Change and COPE Religion). Discussion: The Greek version of the PTGI appears to be a psychometrically sound instrument for measuring PTG during COVID-19 among Greeks.