Objective: This article is a review of outcome studies focusing on three social work fields of service—health, substance abuse, and mental health—in which Latinos were significantly represented in the sample and interventions developed to attend to cultural factors. Method: Data were collected from a search of several English language social science indexes to identify experimental or quasi-experimental studies published between 1999 and 2005 focusing on measuring the effect of cultural adaptations of interventions with Latino populations. Results: Twenty-three studies were located and reviewed. Findings are discussed in this article. Conclusions: Most studies with positive outcomes for Latinos used some culturally tailored variation of cognitive theory in the therapeutic intervention. The authors advocate for a mixed methods approach to future studies of Latinos.