Tooth eruption is defined as the movement of a tooth from its site of development within the jaws to its position of function within the oral cavity. We present a critical review of evidence for the mechanisms and regulation of the intraosseous and supraosseous phases of eruption, with an emphasis upon the canine premolar model studied by the authors. Analyses at different stages of premolar eruption indicate that selective fragmentation of dental follicle protein DF-95 correlates with the presence of elevated levels of follicular collagenase and stromelysin, and with the onset of premolar movement. A dramatic decrease in these metalloproteinases followed initiation of movement. A biochemical and cell biological model for regulation of tooth eruption is proposed based upon these new and existing data.
References
1.
Albelda, S.M. and C.A. Buck: Integrins and other cell adhesion molecules. FASEB J. 4:2868-2880 (1990).
2.
Anderson, T.R., S.U. Toverud, R.C.-W. Yung, M.H. Hanks and J.F. Palik: Separation and partial purification of acid phosphatases of the enamel organ of rat molars. Arch. Oral Biol.27:129-132 (1982).
3.
Andreasen, J. 0.: Ectopic eruption of permanent canines eliciting resorption of incisors: treatment by autotransplantation of the canine. Tandlegbladet. 91:487-492 (1987).
4.
Barfoed, C.P., L.H. Neilsen and J.O. Andreasen: Injury to developing canines as a complication of intranasal antrostomy. Report of a case. Int. J. Oral Surg.13:445-447 (1984).
5.
Beertsen, W. and K.A. Hoeben: Movement of fibroblasts in the periodontal ligament of the mouse incisor is related to eruption. J. Dent. Res. 66:1006-1010 (1987).
6.
Berkovitz, B.K.B.: The effect of root transection and partial root resection on the unimpeded eruption rate of the rat incisor. Arch. Oral Biol. 16:1033-1043 (1971).
7.
Berkovitz, B.K.B.: Structural observations on the periodontal ligament in relation to the eruptive mechanism. In The Biological Mechanisms of Tooth Eruption and Root Resorption. Z. Davidovitch, Ed. EBSCO Media, Birmingham, AL. (1988) 277-291.
8.
Berkovitz, B.K.B.: Unimpeded eruption in the root-resected lower incisor of the rat with a preliminary note on root transection. Arch. Oral Biol. 14:771-780 (1969).
9.
Berkovitz, B.K.B., A. Migdalski and M. Solomon: The effect of the lathyritic agent aminoacetonitrile on the unimpeded eruption rate in normal and root-resected rat lower incisors. Arch. Oral Biol. 17:1755-1763 (1972).
10.
Bernick, S. and D.A. Grant: Development of the periodontal ligament. In The Periodontal Ligament in Health and Disease. B. K. B. Berkovitz, G. J. Moxham and H. N. Newman, Eds. Pergamon Press, Oxford. (1982) 197-213.
11.
Bjork, A. and V. Skieller: Facial development and tooth eruption. An implant study at the age of puberty. Am. J. Orthodont. 62:339-383 (1972).
12.
Bjork, A. and V. Skieller: Growth on the maxilla in three dimensions as revealed radiographically by the implant method. Br. J. Orthodont. 4:53-64 (1976).
13.
Brash, J.C.: The growth of the alveolar bone and its relation to the movements of the teeth including eruption. Int. J. Orthodont. 14:196-223, 283-293, 298-405, 487-494, 494-504 (1928).
14.
Brin, I., Y. Zilberman, D. Galili and A. Fuks: Eruption of rootless teeth in congenital renal disease. Oral Surg. Oral Med. Oral Pathol. 60:61-64 (1985).
15.
Brodie, A.G.: Present status of knowledge concerning movement of the tooth germ through the jaw. J. Am. Dent. Assoc. 21:1830-1838 (1934).
16.
Cahill, D.R.: Eruption pathway formation in the presence of experimental tooth impaction in puppies. Anat. Rec. 164:67-78 (1969).
17.
Cahill, D.R.: Histological changes in the bony crypt and gubemacular canal of erupting permanent premolars during deciduous premolar exfoliation in beagles. J. Dent. Res. 53:786-791 (1974).
18.
Cahill, D.R. and S.C. Marks, Jr.: Tooth eruption: evidence for the central role of the dental follicle. J. Oral Pathol. 9:189-200 (1980).
19.
Cahill, D.R. and S.C. Marks, Jr.: Chronology and histology of exfoliation and eruption of mandibular premolars in dogs. J. Morphol. 171:213-218 (1982).
20.
Cahill, D.R., S.C. Marks, Jr. G.E. Wise and J.P. Gorski: A review and comparison of tooth eruption systems used in experimentation - a new proposal on tooth eruption. In The Biological Mechanisms of Tooth Eruption and Root Resorption. Z. Davidovitch, Ed., EBSCO Media, Birmingham, AL. (1988) 1-7.
21.
Carl, W. and R. Wood: Effects of radiation on the developing dentition and supporting bone. J. Am. Dent. Assoc. 101:646-648 (1980).
22.
Carlson, H.: Studies on the rate and amount of eruption of certain human teeth. Am. J. Orthodont. Surg. 30:575-588 (1944).
23.
Carter, J., A.C. Smillie and M.G. Shepherd: Purification and properties of a protease from developing porcine dental enamel. Arch. Oral Biol. 34:195-202 (1989).
24.
Cohen, S.: Isoation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J. Biol. Chem. 237:1555-1562 (1962).
25.
Dayer, J.M., B. Derochemonteix, B. Burrus, S. Demcyuk and C.A. Dinarello: Human recombinant interleukin-1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J. Clin. Invest. 77:645-648 (1986).
26.
Denbestem, P.K. and L.M. Heffernan: Separation by polyacrylamide gel electrophoresis of multiple proteases in rat and bovine enamel. Arch. Oral Biol. 34:399-404 (1989).
27.
Denbesten, P.K., L.M. Heffernan, B.V. Treadwell and B.J. Awbrey: The presence and possible functions of the matrix metalloproteinase collagenase activator protein in developing enamel matrix. Biochem. J.264:917-920 (1989).
28.
Dzandu, J.K., M.E. Deh, D.L. Barratt and G.E. Wise: Detection of erythrocyte membrane proteins, sialoproteins, and lipids in the same polyacrylamide gel using a double-staining technique. Proc. Natl. Acad. Sci. U.S.A.81:1733-1737 (1984 ).
29.
Eldeeb, M., D. Gatto, R. Edmunds and D. Waite: Alveolar bone graft resorption associated with abnormal dental follicle. Cleft Pal. J. 21:22-28 (1984).
30.
Everts, V. and W. Beertsen: The cellular basis of tooth eruption: the role of collagen phagocytosis. In The Biological Mechanisms of Tooth Eruption and Root Resorption. Z. Davidovitch, Ed. EBSCO Media, Birmingham, AL. (1988 ) 237-242.
31.
Fincham, A.G. and A.B. Belcourt: Amelogenin biochemistry: current concepts. In The Chemistry and Biology of Mineralized Tissues. W. T. Butler, Ed. EBSCO Media, Birmingham, AL. (1985) 240-247.
32.
Fini, E.M., M. Karmilowicz, P. Ruby, A. Beeman, K. Borges, and C. Brinckerhoff: Cloning of a complementary DNA for rabbit proactivator. Arthr. Rheum. 30:1254-1264 (1987 ).
33.
Gary, A., T.J. Dull and A. Ullrich: Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000 molecular weight precursor. Nature. 303:722-725 (1983).
34.
Gavrilovic, J., J.J. Reynolds and G. Murphy: Inhibition of type I collagen film degradation by tumor cells using a specific antibody to collagenase and the specific tissue inhibitor of metalloproteinases (TIMP). Cell Biol. Int. Rep. 9:1097-1107 (1985).
35.
Goldberg, G.I., S.M. Wilhelm, A. Kronberger, E.A. Bauer, G.A. Grant and A.Z. Eisen: Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein. J. Biol. Chem.261:6600-6605 (1986).
36.
Goldfarb, R.H. and L.A. Liotta: Proteolytic enzymes in cancer and invasion and metastasis. Semin. Thromb. Hemostasis. 12:294-307 (1986).
37.
Gorski, J.P., S.C. Marks, Jr., D.R. Cahill and G.E. Wise: Developmental changes in the extracellular matrix of the dental follicle during tooth eruption. Connect. Tissue Res. 18:175-190 (1988a).
38.
Gorski, J.P., S.C. Marks, Jr., D.R. Cahill and G.E. Wise: Biochemical analysis of the extracellular matrix of the dental follicle at different stages of tooth eruption. In The Biological Mechanisms of Tooth Eruption and Root Resorption. Z. Davidovitch, Ed. EBSCO Media, Birmingham, AL. (1988b) 251-260
39.
Gorski, J.P., D. Griffin, G. Dudley, C. Stanford, R. Thomas, C. Huang, E. Lai, B. Karr and M. Solursh: Bone acidic glycoprotein-75 is a major synthetic product of osteoblastic cells and localized as 75- and/or 50-kDa forms in mineralized phases of bone and growth plate and in serum. J. Biol. Chem. 265:14956-14963 (1990).
40.
Gowgiel, J.M.: Eruption of irradiation-produced rootless teeth in monkeys. J. Dent. Res. 40:538-547 (1961).
41.
Gregg, J.M.: Immobilization of the erupting molar in the Syrian hamster. J. Dent. Res. 44:1219-1226 (1965).
42.
Gregg, J.M. and J.K. Avery: Studies of alveolar bone growth and tooth eruption using tetracycline-induced fluorescence. J. Oral Therapeut. Pharmacol. 1:268-281 (1964).
43.
Gross, J.: An essay on biological degradation of collagen. In Cell Biology of the Extracellular Matrix. E. D. Hay, Ed. NY. Plenum Press, New York. (1981) 217-258.
44.
Heussen, C. and E.B. Dowdle: Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem. 102:196-202 (1980).
45.
Hoffman, R.L.: Formation of periodontal tissues around subcutaneously transplanted hamster molars. J. Dent. Res. 39:781-798 (1960).
46.
Holian, A. and R. Scheule: Alveolar macrophage biology. Hosp. Practice. Dec. 15:53-62 (1990).
47.
Jacobson, A.: The physiology of tooth eruption. Birth defects. Orig. Article Ser. 19:67-82 (1983).
48.
Kameyama, Y.: The pattern of alveolar bone activity during development and eruption of the molar in the rat. J. Periodont. Res. 8:179-191 (1973).
49.
Kenny, E.B. and S.P. Ramfjord: Patterns of root and alveolar-bone growth associated with development and eruption of teeth in Rhesus monkeys. J. Dent. Res. 48:251-256 (1969).
50.
Kerr, D.A., R.M. Courtney and E.J. Burkes: Multiple idiopathic root resorption. Oral Surg. 29:552-565 (1970).
51.
Kerr, L., N. Olashaw and L. Matrisian: Transforming growth factor betal and cAMP inhibit transcription of epidermal growth factor- and oncogene-induced transin RNA. J. Biol. Chem. 263:16999-17005 (1988).
52.
Kristerson, L.: Autotransplantation of human premolars: a clinical and radiographic study of 100 teeth. Int. J. Oral Surg. 14:200-213 (1985).
53.
Kristerson, L. and J.O. Andreasen: Autotransplantation and replantation of tooth germs in monkeys. Int. J. Oral Surg.13:324-333 (1984).
54.
Kronfeld, R.: The resorption of the roots of deciduous teeth. Dental Cosmos. 74:103-120 (1932).
55.
Landsberger, R.: Histologic research concerning the growth of the alveolar process in its relation to the development of the tooth germ. Dental Cosmos. 66:1334-1345 (1924).
56.
Liotta, L.A., R.C. Nageswara and U.M. Wewer: Biochemical interactions of tumour cells with the basement membrane. Ann. Rev. Biochem. 55:1037-1057 (1986 ).
57.
Magnusson, B.: Tissue Changes During Molar Tooth Eruption. Transactions of the Royal School of Dentistry, Stockholm and Umeå, Vol. 13, (1968) 1-122.
58.
Magnusson, B.: Autoradiographic study of erupting teeth in rats after intracardial injection of 131I-fibrinogen. Scand. J. Dent. Res. 81:130-134 (1973).
59.
Marks, Jr. S.C.: Tooth eruption: the regulation of a localized, bilaterally symmetrical metabolic event in alveolar bone. Scan. Microsc.1:1125-1133 (1987).
60.
Marks, Jr. S.C., D.R. Cahill and G.E. Wise: The cytology of the dental follicle and adjacent alveolar bone during tooth eruption. Am. J. Anat.168:277-289 (1983).
61.
Marks, Jr. S.C. and D.R. Cahill: Experimental study in the dog of the non-active role of the tooth in the eruptive process. Arch. Oral Biol.29:311-322 (1984).
62.
Marks, Jr. S.C. and D.R. Cahill: Ultrastructure of alveolar bone during tooth eruption in the dog. Am. J. Anat.177:427-438 (1986).
63.
Marks, Jr. S.C. and D.R. Cahill: Regional control of alveolar bone metabolism by the dental follicle during tooth eruption. J. Oral Pathol.16:164-169 (1987).
64.
Marks, Jr. S.C., J.P. Gorski, D.R. Cahill and G.E. Wise: Tooth Eruption - a synthesis of experimental observations. In The Biological Mechanism of Tooth Eruption and Root Resorption. Z. Davidovitch, Ed. EBSCO Media, Birmingham, AL. (1988) 161-169.
65.
Marks, Jr., S.C. and M.-L. Grolman: Tartrate-resistant acid phosphatase in mononuclear and multinuclear cells during the bone resorption of tooth eruption. J. Histochem. Cytochem. 35:1227-1230 (1987).
66.
Marks, Jr., S.C. and S.N. Popoff: Bone cell biology: the regulation of development, structure, and function in the skeleton. Am. J. Anat.183:1-44 (1988).
67.
Martel-Pelletier, J., J.-P. Pelletier, J.-M. Cloutier, D.S. Howell, L. Grandur-Mnaymneh and J.F. Woessner: Neutral proteases capable of proteoglycan digesting activity in osteoarthritis and normal human articular cartilage. Arthr. Rheum. 27:305-312 (1984).
68.
Martin, G.R. and R. Timpl: Laminin and other basement membrane components. Ann. Rev. Cell Biol. 3:57-85 (1987).
69.
Massler, M. and I. Schour: Studies in tooth development: theories of eruption. Am. J. Orthodont. Oral Surg. 27:552-578 (1941).
70.
Melcher, A.H. and Correia: Remodeling of periodontal ligament in erupting molars of mature rats. J. Periodont. Res.6:118-125 (1971).
71.
Menanteau, J., D. Mitre and S. Raher: An in vitro study of enamel protein degradation in developing bovine enamel. Arch. Oral Biol. 31:807-810 (1986).
72.
Michaeli, Y., S. Pitaru and G. Zajicek: Localized damage to the periodontal ligament and its effect on the eruptive process of the rat incisor. J. Periodont. 17:300-308 (1982).
73.
Mignatti, P., E. Robbins and D.B. Rifkin: Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade. Cell. 47:487-498 (1986).
74.
Mignatti, P., R. Tsuboi, E. Robbins and D.B. Rifkin: In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J. Cell Biol.108:671-682 (1989).
75.
Moe, D. and S. Kirkeby: Non-specific esterases in partly mineralized bovine enamel. Acta Odontol. Scand. 48:327-332 (1990).
76.
Moscatelli, D., M. Presta and D.B. Rifkin: Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration. Proc. Natl. Acad. Sci. U.S.A. 83:2091-2095 (1986 ).
77.
Mullins, D.E. and S.T. Rohrlich: The role of proteinases in cellular invasiveness. Biochim. Biophys. Acta. 695:177-214 (1983).
78.
Nagase, H.: Matrix metalloproteinases 1, 2 and 3: substrate specificities and activation mechanisms. In Extracellular Matrix of the Uterus, Cervix, and Fetal Membranes. P. C. Leppert and J. F. Woessner, Jr., Eds., in press.
79.
Nanci, A., J.P. Ahluwalia, S. Zalzal and C.E. Smith: Cytochemical and biochemical characterization of glycoproteins in forming and maturing enamel of the rat incisor. J. Histochem. Cytochem. 37:1619-1633 (1989).
80.
Nanci, A., M. Bendayan and H.C. Slavkin: Enamel protein biosynthesis and secretion in mouse incisor secretory ameloblasts as revealed by high-resolution immunocytochemistry. J. Histochem. Cytochem. 33:1153-1160 (1985).
81.
O'Brien, C., S.N. Bhasker and A.G. Brodie: Eruptive mechanism and movement in the first molar of the rat. J. Dent. Res. 37:467-481 (1958).
82.
Orton, H.S. and F. McDonald: The eruptive potential of teeth: a case report of a wandering lower second premolar. J. Orthodont. 8:242-246 (1986).
83.
Overall, M.C. and H. Limeback: Identification and characterization of enamel proteinases from developing enamel. Biochem. J. 256:965-972 (1988).
84.
Palmer, R.M. and A.G.S. Lumsden: Development of periodontal ligament and alveolar bone in homografted recombinations of enamel organs and papillary, pulpal and follicular mesenchyme in the mouse. Arch. Oral Biol. 32:281-289 (1987).
85.
Pauli, B.U. and W. Knudsen: Tumor invasion: a consequence of destructive and compositional matrix alterations. Hum. Pathol. 19:628-639 (1988).
86.
Pearson, C.H., M. Wohllebe, D.J. Carmichael and A. Chovelon: Bovine periodontal ligament. An investigation of the collagen, glycosaminoglycan, and insoluble glycoprotein components at different stages of tissue development. Conn. Tiss. Res.3:195-206 (1975).
87.
Perera, K.A.S. and C.H. Tonge: Fibroblast cell proliferation in the mouse molar periodontal ligament. J. Anat. 133:77-90 (1981a).
88.
Perera, K.A.S. and C.H. Tonge: Metabolic turnover of collagen in the mouse molar periodontal ligament during tooth eruption. J. Anat. 133:359-370 (1981b).
89.
Pitaru, S., Y. Michaeli, G. Zajicek and M.M. Weinrib: Role of attrition and occlusal contact in the physiology of the rat incisor X. The part played by the periodontal ligament in the eruptive process. J. Dent. Res. 55:819-824 (1976).
90.
Rice, W.G. and S.J. Weiss: Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science249:178-181 (1990).
91.
Robinson, C., J.A. Weatjerell, I. El-Attar and D. Deutsch: The pattern of mineral uptake in developing bovine incisors. Caries Res. 14:389-392 (1980).
92.
Skobe, Z.: The vascular pattern in the papillary region of rat incisor and molar tooth enamel organ. J. Dent. Res. 59:1457-1460 (1980).
93.
Smith, C.E., J.R. Pompura, S. Borenstein, A. Fazel and A. Nanci: Degradation and loss of matrix proteins from developing enamel. Anat. Rec. 224:292-316 (1989).
94.
Snead, M.L., W. Luo, P. Oiiver, M. Nakamura, G. Don-Wheeler, C. Bessen, G.I. Bell, L.B. Rall and H.C. Slavkin: Localization of epidermal growth factor precursor in tooth and lung during embryonic mouse development. Dev. Biol.134:420-429 (1989).
95.
Steedle, J.R. and W.R. Proffit: The pattern and control of eruptive tooth movements. Am. J. Orthodont. 87:56-66 (1985).
96.
Suga, S.: Histochemical observation of proteolytic enzyme activities in the developing dental hard tissues of the rat. Arch. Oral Biol. 15:555-558 (1970).
97.
Suzuki, K., J.J. Enghild, T. Morodomi, G. Salvesen and H. Nagase: Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (Stromelysin). Biochemistry. 29:10261-10270 (1990).
98.
ten Cate, A.R.: Morphological studies of fibrocytes in connective tissue undergoing rapid remodelling. J. Anat.112:401-414 (1972).
99.
ten Cate, A.R.: Formation of supporting bone in association with periodontal ligament organization in the mouse. Arch. Oral Biol.20:137-138 (1975).
100.
ten Cate, A.R. and D.A. Deporter: The degradative role of the fibroblast in the remodelling and turnover of collagen in soft connective tissue. Anat. Rec.1&2:1-14 (1975).
101.
ten Cate, A.R., C. Mills and G. Solomon: The development of the periodontium. A transplantation and autoradiographic study. Anat. Rec.170:365-380 (1971).
102.
Thesleff, I.: Does epidermal growth factor control tooth eruption? J. Dent. Childr. 54:321-329 (1987).
103.
Thesleff, I., A.-M. Partanen and L. Rihtniemi: Localization of epidermal growth factor receptors in mouse incisors and human premolars during eruption. Eur. J. Orthodon. 9:24-32 (1987).
104.
Thorgeirsson, U.P., L.A. Liotta, T. Kalebic, I.M. Marguiles, K. Thomas, M. Rios-Candelore and R.G. Russo: Effect of natural protease inhibitors and a chemoattractant on tumor invasion in vitro, J. Natl. Cancer Inst.69:1049-1054 (1982).
105.
Topham, R.T., G.J. Chiego, Jr., V.H. Gattone II, D.A. Hinton and R.M. Klein: The effect of epidermal growth factor on neonatal incisor differentiation in the mouse. Dev. Biol.124:532-543 (1987).
106.
Tsuruta, M., K. Eto and M. Chiba: Effect of daily or 4 hourly administrations of lathyrogens on the eruption rates of impeded and unimpeded mandibular incisors of rats. Arch. Oral Biol. 19:1221-1226 (1974).
107.
Wahl, S.M., D.A. Hunt, L.M. Wakefield, N. McCartney-Francis, L.M. Wahl, A.B. Roberts and M.B. Spom: Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad. Sci. U.S.A.84:5788-5792 (1987).
108.
Weinmann, J.P.: Bone changes related to eruption of the teeth. Angle Orthodon. 11:83-99 (1941).
109.
Weinmann, J.P.: Eruption of the teeth In Oral Histology and Embryology chap. XI, B. J. Orban, Ed. C. V. Mosby, St. Louis. 301-319 (1944).
110.
Weiss, S.J. and G.J. Peppin: Collagenolytic metalloproteinases of the human neutrophil: characterizatics, regulation, and potential function in vivo. Biochem. Pharmacol. 35:3189-3197 (1986).
111.
Werb, Z.: Proteinases and matrix degradation. In Textbook of Rheumatology. W. N. Kelley, E. D. Harris Jr., S. Ruddy, and C. B. Sledge, Eds. W. B. Saunders, Philadelphia. chap. 18, (1989) 300-321 (1989).
112.
Whitham, S.E., G. Murphy, P. Angel, H.J. Rahmsdorf, B.J. Smith, A. Lyons, T.J.R. Harris, J.J. Reynolds, P. Herrlich and A.J.P. Docherty: Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem. J.240:913-916 (1986).
113.
Wise, G.E., S.C. Marks Jr. and D.R. Cahill: Ultrastructural features of the dental follicle associated with formation of the tooth eruption pathway in the dog. J. Oral Pathol. 14:15-26 (1985).
114.
Wise, G.E., S.C. Marks Jr., D.R. Cahill and J.P. Gorski: Ultrastructural features of the dental follicle and enamel organ prior to and during tooth eruption. In The Biological Mechanisms of Tooth Eruption and Root Resorption. Z. Davidovitch, Ed. EBSCO Media, Birmingham, AL. (1988) 243-249.
115.
Wise, G.E. and W. Fan: Changes in the tartrate-resistant acid phosphatase cell population in dental follicles and bony crypts of rat molars during tooth eruption. J. Dent. Res. 68:150-156 (1989).
116.
Wise, G.E. and W. Fan: Immunolocalization of transforming growth factor beta in rat molars. J. Oral Pathol. Med. 20:74-80 (1991).
117.
Wiseman, D.M., P.J. Polverine, D.W. Kamp and S.J. Leibovich: Transforming growth factor-beta (TGF-beta) is chemostatic for human monocytes and induces their expression of angiogenic activity. Biochem. Biophys. Res. Commun.157:793-800 (1988).
118.
Woolley, D.E.: Mammalian collagenases. In Extracellular Matrix Biochemistry. K. A. Piez and A. H. Reddi, Eds. Elsevier, New York. (1984) 119-157
119.
Yoshikawa, D.K. and E.J. Kollar: Recombination experiments on the odontogenic roles of mouse dental papilla and dental sac tissues in ocular grafts. Arch. Oral Biol. 26:303-307 (1981).
