In this paper, we shall review several chronic orofacial pain conditions with emphasis on those that are essentially refractory to treatment. We shall present a review of current and past literature that describes the various pain phenomena as well as their underlying central mechanisms. New data concerning refractory pain will be used to underscore the importance of central processing of pain, with particular emphasis on neuropsychological and cognitive function and capacity that may play important roles in pain processing and maintenance of the pain state. Further, neurophysiological data showing that the anterior cingulate cortex (ACC) and other structures in the brain may play key roles in modulation of chronic pain will also be discussed. Although peripheral triggering events surely play an important role in initiating pain, the development of chronic and, in particular, refractory pain may depend on changes or malfunctions in the central nervous system. These changes may be quite subtle and require sophisticated approaches, such as functional MRI, to study them, as is now being done. New findings obtained therefore may lead to more rational and reliable treatment for orofacial pain.
References
1.
Aaron LA, Burke MM, Buchwald D. (2000). Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder. Arch Intern Med160:221-227.
2.
Aghabeigi B., Feinmann C., Harris M. (1992). Prevalence of posttraumatic stress disorder in patients with chronic idiopathic facial pain. Br J Oral Maxillofac Surg30:360-364.
3.
Albe-Fessard D., Berkley KJ, Kruger L., Ralston H. Jr, Willis WDJ (1985). Diencephalic mechanisms of pain sensation. Brain Res356:217-296.
4.
Anderson JM, Kaplan MS, Felsenthal G. (1990). Brain injury obscured by chronic pain: a preliminary report. Arch Phys Med Rehabil71:703-708.
5.
Augustine JR (1985). The insular lobe in primates including humans. Neurolog Res7:2-10.
6.
Augustine JR (1996). Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev22:229-244.
7.
Bell WE ( 1989). Orofacial pains. Classification, diagnosis, management. 4th ed. Chicago: Year Book Medical Publishers.
8.
Benoliel R., Sharav Y. (1998). Neuropathic orofacial pain. Compend Contin Educ Dent19:1099-1102.
9.
Berkley KJ, Parmer R. (1974). Somatosensory cortical involvement in responses to noxious stimulation in the cat. Exp Brain Res20:363-374.
10.
Bessette L., Carette S., Fossel AH, Lew RA (1998). A placebo controlled crossover trial of subcutaneous salmon calcitonin in the treatment of patients with fibromyalgia. Scand J Rheumatol27:112-116.
11.
Bouckoms AF (1989). Psychosurgery for pain. In: Textbook of pain. Wall PD, Melzack R, editors. Edinburgh: Churchill Livingstone, pp. 868-881.
12.
Braun BL, DiGiovanna A., Schiffman E., Bonnema J., Fricton J. (1992). A cross-sectional study of temporomandibular joint dysfunction in post-cervical trauma patients. J Craniomandib Disord Facial Oral Pain6:24-31.
13.
Brooke RI (1980). Atypical odontalgia. A report of twenty-two cases. Oral Surg Oral Med Oral Pathol49:196-199.
14.
Brooke RI, Stenn PG (1978). Postinjury myofascial pain dysfunction syndrome: its etiology and prognosis. Oral Surg Oral Med Oral Pathol45:846-850.
Burgess J. (1991). Characteristics in temporomandibular disorders patients reporting blunt trauma and/or whiplash injury. J Craniomandib Disord Facial Oral Pain5:251-257.
17.
Burgess JA, Dworkin SF (1993). Litigation and posttraumatic temporomandibular disorder: how patients report treatment outcome. J Am Dent Assoc124:105-110.
18.
Carlson CR, Okeson JP, Falace DA, Nitz AJ, Curran SL, Anderson D. (1993). Comparison of psychologic and physiologic functioning between patients with masticatory muscle pain and matched controls. J Orofacial Pain7:15-22.
19.
Carlsson GE, DeBoever JA (1994). Epidemiology. In: Temporomandibular joint and masticatory muscle disorders. Zarb GA, Carlsson GE, Sessle BJ, Mohl ND, editors. Copenhagen: Munksgaard, p. 165.
20.
Casey KL, Minoshiman S., Berger KL, Koeppe RA, Morrow TJ, Frey KA ( 1994). Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli. J Neurophysiol71:802-807.
21.
Casey KL, Minoshima S., Morrow TJ, Koeppe RA (1996). Comparison of human cerebral activation patterns during cutaneous warmth, heat pain and deep cold pain. J Neurophysiol76:571-581.
22.
Cesta A., Moldofsky H., Sammut C. (1996). The University of Toronto sleep assessment questionnaire (SAQ). Sleep Res25:486.
23.
Chudler EJ, Dong WK, Kawakami Y. (1986). Cortical nociceptive responses and behavioral correlates in the monkey. Brain Res397:47-60.
24.
Chudler EH, Anton F., Dubner R., Kenshalo DRJ (1990). Responses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of inter-stimulus interval. J Neurophysiol63:559-569.
25.
Classification Committee of the International Headache Society (1988). Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia8:1-96.
26.
Cohen DA, Prud'homme MJ, Kalaska JF (1994). Tactile activity in primate primary somatosensory cortex during active arm movements: correlation with receptive field properties. J Neurophysiol71:161-172.
27.
Cote KA, Moldofsky H. (1997). Sleep, daytime symptoms, and cognitive performance in patients with fibromyalgia. J Rheumatol24:2014-2023.
28.
Craig AD (1995). Supraspinal projections of lamina I neurons. In: Forebrain areas involved in pain processing. Besson JM, Guilbaud G, Olat H, editors. Paris: John Libbey Eurotext, pp. 13-25.
29.
Craig AD, Dostrovsky JO (1997). Processing of nociceptive information at supraspinal levels. In: Anesthesia: biologic foundations. Yaksh TL, editor. Philadelphia: Lippincott-Raven Publishers, pp. 625-642.
30.
Craig AD, Bushnell MC, Zhang ET, Blomqvist A. (1994). A thalamic nucleus specific for pain and temperature sensation. Nature372:770-773.
31.
Craig AD, Reiman EM, Evans A., Bushnel MD (1996). Functional imaging of an illusion of pain. Nature384:258-260.
32.
Davis KD, Meyer RA, Campbell JN (1993). Chemosensitivity and sensitization of nociceptive afferents that innervate the hairy skin of monkey. J Neurophysiol69:1071-1081.
33.
Davis KD, Hutchinson WD, Lozano AM, Dostrovsky JO (1994). Altered pain and temperature perception following cingulotomy and capsulotomy in a patient with schizoaffective disorder. Pain59:189-199.
34.
Davis KD, Wood ML, Crawley AP, Mikulis DJ (1995). fMRI of human somatosensory and cingulate cortex during painful electrical nerve stimulation. Neuroreport7:321-325.
35.
Davis KD, Kiss ZH, Tasker RR, Dostrovsky JO (1996). Thalamic stimulation-evoked sensations in chronic pain patients and in non-pain (movement disorder) patients. J Neurophysiol75:1026-1037.
36.
Davis KD, Taylor SJ, Crawley AP, Wood ML, Mikulis DJ (1997). Functional MRI of pain- and attention-related activations in the human cingulate cortex. J Neurophysiol77:3370-3380.
37.
Davis KD, Kiss ZH, Luo L., Tasker RR, Lozano AM, Dostrovsky JO (1998a). Phantom sensations generated by thalamic microstimulation. Nature391:385-387.
38.
Davis KD, Kwan CL, Crawley AP (1998b). fMRI of the anterior cingulate cortex during painful, thermal, and motor tasks in individual subjects (abstract). Neuroimage7:S426.
39.
Davis KD, Kwan CL, Crawley AP, Mikulis DJ (1998c). Event-related fMRI of pain: entering a new era in imaging pain. Neuroreport9:3019-3023.
40.
Davis KD, Kwan CL, Crawley AP, Mikulis DJ (1998d). Functional MRI study of thalamic and cortical activations evoked by cutaneous, cold and tactile stimuli. J Neurophysiol80:1533-1546.
41.
Delis DC, Freeland J., Kramer JH, Kaplan E. (1988). Integrating clinical assessment with cognitive neuroscience: construct validation of the California Verbal Learning Test. J Consult Clin Psychol56:123-130.
42.
Derbyshire SW, Jones AK, Devani P., Friston KJ, Feinmann C., Harris M., et al., editors (1994). Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography. J Neurol Neurosurg Psychiat57:1166-1173.
43.
Devinsky O., Morrell MJ, Vogt BA ( 1995). Contributions of anterior cingulate cortex to behaviour. Brain118:279-306.
44.
Di Piero V., Ferracuti S., Sabatini U., Pantano P., Cruccu G., Lenzi GL (1994). A cerebral blood flow study on tonic pain activation in man. Brain56:167-174.
45.
Dong WK, Salonen LD, Kawakami Y., Shiwaku T., Kaukoranta EM, Martin RF (1989). Nociceptive responses of trigeminal neurons in SII-7b cortex of awake monkeys. Brain Res484:314-324.
46.
Dostrovsky JO, Craig AD (1996). Nociceptive neurons in primate insular cortex (abstract). Soc Neurosci22:1111.
47.
Dostrovsky JO, Davis KD, Kawakita K. (1991). Central mechanisms of vascular headaches. Can J Physiol Pharmacol69:652-658.
48.
Dostrovsky JO, Hutchinson WD, Davis KD (1995). Potential role of orbital and cingulate cortices in nociception. In: Forebrain areas involved in pain processing. Besson JM, Guilbaud G, Ollat H, editors. Paris: John Libbey Eurotext, pp. 171-181.
49.
Dostrovsky JO, Shah Y., Gray BG ( 1983). Descending inhibitory influences from periaqueductal gray, nucleus raphe magnus, and adjacent reticular formation. II. Effects on medullary dorsal horn nociceptive and nonnociceptive neurons. J Neurophysiol49:948-960.
50.
Dworkin SF (1991). Illness behavior and dysfunction: review of concepts and application to chronic pain. Can J Physiol Pharmacol69:662-671.
51.
Dworkin SF, LeResche L. (1992). Research diagnostic criteria for temporomandibular disorders. J Craniomandib Disord Facial Oral Pain6:301-355.
52.
Dworkin SF, LeResche L., von Korff M., Truelove E., Sommers E. (1989). Predicting continued presence and level of temporomandibular disoder pain (abstract). J Dent Res68:194.
53.
Dworkin SF, Huggins KH, LeResche L., Von Korff M., Howard J., Truelove E., et al. (1990). Epidemiology of signs and symptoms in temporomandibular disorders: clinical signs in cases and controls. J Am Dent Assoc120:273-281.
54.
Dworkin SF, LeResche L., von Korff M., Dicker B., Sommers E. (1991). Constant, remitted and cyclic pain patterns in temporomandibular disorder: three-year follow-up (abstract). J Dent Res70:441.
55.
Feinmann C., Harris M., Cawley R. (1984). Psychogenic facial pain: presentation and treatment. Br Med J (Clin Res Ed)288:436-438.
Frazier CH, Russell EC (1924). Neuralgia of the face. An analysis of seven hundred and fifty four cases with relation to pain and other sensory phenomena before and after operation. Arch Neurol Psychiatry11:557-563.
58.
Freeman BV, Psutka DJ, Hunter JJ, Baker GI (1998). Arthroscopy of the temporomandibular joint: a comparison of objective and subjective outcome measures in patients with and without evidence of a psychopathologic disorder. Alpha Omegan91:44-50.
59.
Fricton JR, Olsen T. (1996). Predictors of outcome for treatment of temporomandibular disorders. J Orofacial Pain10:54-65.
60.
Friedman DP, Murray EA (1986). Thalamic connectivity of the second somatosensory area and neighboring somatosensory fields of the lateral sulcus of the Macaque. J Comp Neurol252:348-373.
61.
Galli G., Gordon A., Shandling M., Mock D., Tenenbaum HC (1993). Diagnostic and prognostic features of atypical facial pain: a pilot study (abstract). J Orofacial Pain7:116.
62.
Gatchel RJ, Garofalo JP, Ellis E., Holt C. ( 1996). Major psychological disorders in acute and chronic TMD: an initial examination. J Am Dent Assoc127:1365-1370, 1372, 1374.
63.
Gerschman JA, Wright JL, Hall WD, Reade PC, Burrows GD, Holwill BJ (1987). Comparisons of psychological and social factors in patients with chronic orofacial pain and dental phobic disorders. Aust Dent J32:331-335.
64.
Glassman RB (1994). Behavioral specializations of SI and SII cortex: a comparative examination of the neural logic of touch in rats, cats, and other mammals. Exp Neurol125:134-141.
65.
Goldberg MB, Grossi ML (1998). Refractory temporomandibular disorders: understanding and treating the chronic facial pain patient. Alpha Omegan91:38-43.
66.
Goldberg MB, Mock D., Ichise M., Proulx G., Gordon A., Shandling M., et al. (1996). Neuropsychologic deficits and clinical features of posttraumatic temporomandibular disorders. J Orofacial Pain10:126-140.
Graff-Radford SB, Solberg WK (1993). Is atypical odontalgia a psychological problem? [see comments]. Oral Surg Oral Med Oral Pathol75:579-582.
69.
Greco CM, Rudy TE, Turk DC, Herlich A., Zaki HH ( 1997). Traumatic onset of temporomandibular disorders: positive effects of a standardized conservative treatment program. Clin J Pain13:337-347.
70.
Greene CS, Laskin DM (1983). Long-term evaluation of treatment of myofascial pain dysfunction syndrome: a comparative analysis. J Am Dent Assoc107:235-238.
71.
Greene CS, Olson RE, Laskin DM (1982). Psychological factors in the etiology, progression, and treatment of MPD syndrome. J Am Dent Assoc105:443-448.
72.
Grossi ML (1998). Neuropsychological deficits as predictors of treatment outcome in patients with temporomandibular disorders. (PhD Thesis) University of Toronto: Graduate Department of Dentistry.
73.
Grossi ML, Goldberg MB, Locker DJ, Mock D., Tenenbaum HC (1998). Neuropsychological testing, chronic pain and temporomandibular disorders (abstract). J Dent Res77:112.
74.
Grushka M., Sessle BJ, Howley TP (1986). Psychophysical evidence of taste dysfunction in burning mouth syndrome. Chem Senses11:485-498.
75.
Grushka M., Sessle BJ, Howley TP (1987). Psychophysical assessment of tactile, pain and thermal sensory functions in burning mouth syndrome. Pain28:169-184.
76.
Habler HJ, Janig W., Koltzenburg M. (1990). Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol (Lond)425:545-562.
77.
Handwerker HO, Kilo S., Reeh PW ( 1991). Unresponsive afferent nerve fibres in the sural nerve of the rat. J Physiol (Lond)435:229-242.
78.
Hari R., Karhu J., Hamalainen M., Knuutila J., Salonen O., Sams M., et al. (1993). Functional organization of the human first and second somatosensory cortices: a neuromagnetic study. Eur J Neurosci5:724-734.
79.
Harris M. (1974). Psychogenic aspects of facial pain. Br Dent J136:199-202.
80.
Hassenbusch SJ, Pillay PK, Barnett GH (1990). Radiofrequency cingulotomy for intractable cancer pain using stereotaxis guided by magnetic resonance imaging. Neurosurgery27:220-223.
81.
Heise AP, Laskin DM, Gervin AS (1992). Incidence of temporomandibular joint symptoms following whiplash injury. J Oral Maxillofac Surg50:825-828.
82.
Howard RP, Benedict JV, Raddin JH, Smith HL (1991). Assessing neck extension-flexion as a basis for temporomandibular joint dysfunction. J Oral Maxillofac Surg49:1210-1213.
83.
Howard RP, Hatsell CP, Guzman HM (1995). Temporomandibular joint injury potential imposed by the low-velocity extension-flexion maneuver. J Oral Maxillofac Surg53:256-263.
84.
Hsieh JC, Belfrage M., Stone-Elander S., Hansson P., Ingvar M. (1995). Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain63:225-236.
85.
Hugenholtz H., Stuss DT, Stethem LL, Richard MT (1988). How long does it take to recover from a mild concussion? Neurosurgery22:853-858.
86.
Hutchison WD, Davis KD, Lozano AM, Tasker RR, Dostrovsky JO (1999). Pain-related neurons in the human cingulate cortex. Nat Neurosci2:403-405.
87.
Iadarola MJ, Max MB, Berman KF, Byas-Smith MG, Coghill RC, Gracely RH, et al. (1995). Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain. Pain63:55-64.
88.
Iadarola MJ, Berman KF, Zeffiro TA, Byas-Smith MG, Gracely RH, Max MB, et al. (1998). Neural activation during acute capsaicinevoked pain and allodynia assessed with PET. Brain121:931-947.
89.
Jaeger H., Maier C. (1992). Calcitonin in phantom limb pain: a double-blind study. Pain48:21-27.
90.
Jones AK, Brown WD, Friston KJ, Qi LY, Frackowiak RS (1991). Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc R Soc Lond B Biol Sci244:39-44.
91.
Kaas JH ( 1983). What, if anything, is SI? Organization of first ' somatosensory area of cortex. Physiol Rev63:206-231.
92.
Kenshalo DRJ, Isensee O (1983). Responses of primate SI cortical neurons to noxious stimuli. J Neurophysiol50:1479-1496.
93.
Kenshalo DRJ, Chudler EH, Anton F., Dubner R. (1988). SI nociceptive neurons participate in the encoding process by which monkeys perceive the intensity of noxious thermal stimulation. Brain Res454:378-382.
94.
Kight M., Gatchel RJ, Wesley L. (1999). Temporomandibular disorders: evidence for significant overlap with psychopathology. Health Psychol18:177-182.
95.
Kinney RK, Gatchel RJ, Ellis E., Holt C. ( 1992). Major psychological disorders in chronic TMD patients: implications for successful management. J Am Dent Assoc123:49-54.
96.
Knecht S., Henningsen H., Elbert T., Flor H., Hohling C., Pantev C., et al. (1996). Reorganizational and perceptional changes after amputation. Brain119:1213-1219.
97.
Kolbinson DA, Epstein JB, Burgess JA (1996). Temporomandibular disorders, headaches, and neck pain following motor vehicle accidents and the effect of litigation: review of literature. J Orofacial Pain10:101-125.
98.
Kolbinson DA, Epstein JB, Senthilselvan A., Burgess JA (1997a). A comparison of TMD patients with or without prior motor vehicle accident involvement: initial signs, symptoms, and diagnostic characteristics. J Orofac Pain11:206-214.
99.
Kolbinson DA, Epstein JB, Senthilselvan A., Burgess JA (1997b). A comparison of TMD patients with or without prior motor vehicle accident involvement: treatment and outcomes. J Orofac Pain11:337-345.
100.
Kolbinson DA, Epstein JB, Senthilselvan A., Burgess JA (1998). Effect of impact and injury characteristics on post-motor vehicle accident temporomandibular disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod85:665-673.
101.
Kreisberg MK (1982). Atypical odontalgia: differential diagnosis and treatment. J Am Dent Assoc104:852-854.
102.
Kudrow L. (1991). Diagnosis and treatment of cluster headache. Med Clin North Am75:579-594.
LeResche L. (1997). Epidemiology of temporomandibular disorders: implications for the investigation of etiologic factors. Crit Rev Oral Biol Med8:291-305.
105.
Loeser JD (1994). Tic douloureux and atypical facial pain. In: Textbook of pain. Wall PD, Melzack R, editors. Edinburgh: Churchill Livingstone, pp. 699-710.
106.
Madison S., Whitsel EA, Suarez-Roca H., Maixner W. (1992). Sensitizing effects of leukotriene B4 on intradental primary afferents. Pain49:99-104.
Marbach JJ, Hulbrock J., Hohn C., Segal AG (1982). Incidence of phantom tooth pain: an atypical facial neuralgia. Oral Surg Oral Med Oral Pathol53:190-193.
109.
Massler M. (1981). Dental causalgia. Quintessence Int12:341-343.
110.
McCreary CP, Clark GT, Merrill RL, Flack V., Oakley ME (1991). Psychological distress and diagnostic subgroups of temporomandibular disorder patients. Pain44:29-34.
111.
McGregor NR, Butt HL, Zerbes M., Klineberg IJ, Dunstan RH, Roberts TK (1996). Assessment of pain (distribution and onset), symptoms, SCL-90R inventory responses, and the association with infectious events in patients with chronic orofacial pain. J Orofacial Pain10:339-350.
112.
Melzack R., Wall PD ( 1965). Pain mechanisms: a new theory. Science150:971-979.
113.
Merskey H., Woodforde JM (1972). Psychiatric sequelae of minor head injury. Brain95:521-528.
114.
Meyer RA, Davis KD, Cohen RH, Treede RD, Campbell JN (1991). Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkey. Brain Res561:252-261.
115.
Meyer RA, Campbell JN, Raja SN ( 1994). Peripheral neural mechanisms of nociception. In: Textbook of pain. Wall PD, Melzack R, editors. New York: Churchill Livingstone, pp. 13-44.
116.
Millstein-Prentky S., Olson RE (1979). Predictability of treatment outcome in patients with myofascial pain-dysfunction (MPD) syndrome. J Dent Res58:1341-1346.
117.
Mock D., Frydman W., Gordon AS (1985). Atypical facial pain: a retrospective study. Oral Surg Oral Med Oral Pathol59:472-474.
118.
Moldofsky H. (1993a). Fibromyalgia, sleep disorder and chronic fatigue syndrome. In: Chronic fatigue syndrome. editors. Ciba Found Symp173:262-271.
119.
Moldofsky H. (1993b). Sleep and musculoskeletal pain. In: Progress in fibromyalgia and myofascial pain. Merskey HL, Vaeroy H, editors. New York: Elsevier Science Publishers, pp. 137-148.
120.
Moskowitz MA (1984). The neurobiology of vascular head pain. Ann Neurol16:157-168.
121.
Mott AE, Grushka M., Sessle BJ (1993). Diagnosis and management of taste disorders and burning mouth syndrome. Dent Clin North Am37:33-71.
122.
Ness TJ, Gebhart GF (1990). Visceral pain: a review of experimental studies. Pain41:167-234.
123.
Neugebauer V., Schaible HG, Schmidt RF (1989). Sensitization of articular afferents to mechanical stimuli by bradykinin. Pflügers Arch415:330-335.
124.
Nielsen AC, Williams TA (1980). Depression in ambulatory medical patients: prevalence by self-report questionnaire and recognition by non-psychiatric physicians. Arch Gen Psychiatry37:999-1004.
125.
Ohrbach R., Dworkin SF (1998). Five-year outcomes in TMD: relationship of changes in pain to changes in physical and psychological variables. Pain74:315-326.
126.
Pankhurst CL (1997). Controversies in the aetiology of temporomandibular disorders. Part 1. Temporomandibular disorders: all in the mind? Prim Dent Care4:25-30.
Probert TCS, Wiesenfeld D., Reade PC (1994). Temporomandibular pain dysfunction disorder resulting from road traffic accidents-an Australian study. Int J Oral Maxillofac Surg23:338-341.
130.
Prud'homme MJ, Cohen DA, Kalaska JF (1994). Tactile activity in primate primary somatosensory cortex during active arm movements: cytoarchitectonic distribution. J Neurophysiol71:173-181.
131.
Pullinger AG, Seligman DA (1991). Trauma history in diagnostic groups of temporomandibular disorders. Oral Surg Oral Med Oral Pathol71:529-534.
132.
Rainville P., Duncan GH, Price DD, Carrier B., Bushnell MC (1997). Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science277:968-971.
Remick RA, Blasberg B., Barton J., Campos PE, Miles JE (1983a). Ineffective dental and surgical treatment associated with atypical facial pain. Oral Surg Oral Med Oral Pathol55:355-358.
135.
Remick RA, Blasberg B., Campos PE, Miles JE (1983b). Psychiatric disorders associated with atypical facial pain. Can J Psychiatry28:178-181.
136.
Riley JL, Robinsong ME, Kvaal SA, Gremillion HA (1998). Effects of physical and sexual abuse in facial pain: direct or mediated? Cranio16:259-266.
137.
Robinson CJ, Burton H. (1980). Somatic submodality distribution within the second somatosensory (SII), 7b, retroinsular, post-auditory, and granular insular cortical areas of M. fascicularis. J Comp Neurol192:93-108.
138.
Romanelli GG, Mock D., Tenenbaum HC (1992). Characteristics and response to treatment of posttraumatic temporomandibular disorders: a retrospective study. Clin J Pain8:6-17.
139.
Roydhouse R. (1973). Whiplash and temporomandibular dysfunction. Lancet1:1394-1395.
140.
Rudy TE, Turk DC, Kubinski JA, Zaki HS ( 1995). Differential treatment responses of temporomandibular patients as a function of psychological characteristics. Pain61:103-112.
141.
Schnurr RF, Rollman GB, Brooke RI (1991). Are there psychologic predictors of treatment outcome in temporomandibular joint pain and dysfunction? Oral Surg Oral Med Oral Pathol72:550-558.
142.
Schoenberg B. (1967). Psychogenic aspects of the burning mouth. NY State Dent J33:467-473.
143.
Schwartz G., Galonski M., Gordon A., Shandling M., Mock D., Tenenbaum HC (1996). Effects of salmon calcitonin on patients with atypical facial pain: a randomized trial. J Orofacial Pain10:306-315.
144.
Schwartz RA, Greene CS, Laskin DM (1979). Personality characteristics of patients with myofascial pain-dysfunction (MPD) syndrome unresponsive to conventional therapy. J Dent Res58:1435-1439.
145.
Sessle BJ (1985). Dental deafferentation can lead to the development of chronic pain. In: Orofacial pain and neuromuscular dysfunction: mechanisms and clinical correlates. Klineberg I, Sessle BJ, editors. Oxford: Pergamon, pp. 115-129.
146.
Sessle BJ (1992). Neurobiology of facial and dental pain. In: The temporomandibular joint: a biological basis for clinical practice. Sarnat BC, Laskin DM, editors. Philadelphia: W.B. Saunders, pp. 124-142.
147.
Sharav Y. (1994). Orofacial pain. 3rd ed. London: Churchill Livingstone.
148.
Sicuteri F., Nicolodi M., Fusco BM, Orlando S. (1991). Idiopathic headache as a possible risk factor for phantom tooth pain. Headache31:577-581.
149.
Sikes RW, Vogt BA ( 1992). Nociceptive neurons in area 24 of rabbit cingulate cortex. J Neurophysiol68:1720-1732.
150.
Small EW (1974). Correlation findings and treatment results in temporomandibular joint pain-dysfunction syndrome. J Oral Surg32:589-592.
Stegenga B., de Bont LG, Dijkstra PU, Boering G. (1993). Short-term outcome of arthroscopic surgery of temporomandibular joint osteoarthrosis and internal derangement: a randomized controlled clinical trial. Br J Oral Maxillofac Surg31:3-14.
153.
Stohler CS, Zarb GA ( 1999). On the management of temporomandibular disorders: a plea for a low-tech, high-prudence therapeutic approach. J Orofac Pain13:255-261.
154.
Stuss DT, Ely P., Hugenholtz H., Richard MT, LaRochelle S., Poirier CA, et al. (1985). Subtle neuropsychological deficits in patients with good recovery after closed head injury. Neurosurgery17:41-47.
155.
Stuss DT, Stethem LL, Hugenholtz H., Picton T., Pivik J., Richard MT (1989a). Reaction time after head injury: fatigue, divided and focused attention, and consistency of performance. J Neurol Neurosurg Psychiatry52:742-748.
156.
Stuss DT, Stethem LL, Picton TW, Leech EE, Pelchat G. (1989b). Traumatic brain injury, aging, and reaction time. Can J Neurol Sci16:161-167.
157.
Svensson P., Minoshima S., Beydoun A., Morrow TJ, Casey KL (1997). Cerebral processing of acute skin and muscle pain in humans. J Neurophysiol78:450-460.
158.
Tasker RR, Organ LW, Hawrylyshyn PA (1982). The thalamus and midbrain of man. A physiological atlas using electrical stimulation. Springfield, IL: C.C. Thomas.
Toda K. ( 1992). Anterior cingulate-induced inhibition of activities of descending periaqueductal gray matter neurons in rats. Pain Res7:71-79.
161.
Treede RD, Meyer RA, Raja SN, Campbell JN (1992). Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol38:397-421.
162.
Turk DC ( 1999). The role of psychological factors in chronic pain. Acta Anaesthesiol Scand43:885-888.
163.
Tversky J., Reade PC, Gerschman JA, Holwill BJ, Wright J. (1991). Role of depressive illness in the outcome of treatment of temporomandibular joint pain-dysfunction syndrome. Oral Surg Oral Med Oral Pathol71:696-699.
164.
Vaccarino AL, Melzack R. (1989). Analgesia produced by injection of lidocaine into the anterior cingulum bundle of the rat. Pain39:213-219.
165.
Vogt BA, Sikes RW, Vogt LJ ( 1993). Anterior cingulate cortex and the medialpain system. In: Neurobiology of cingulate cortex and limbic thalamus: a comprehensive handbook. Vogt BA, Gabriel M, editors. Boston: Birkhauser, pp. 313-344.
Weinberg S., Lapointe H. (1987). Cervical extension-flexion injury (whiplash) and internal derangement of the temporomandibular joint. J Oral Maxillofac Surg45:653-656.
168.
Willis WD (1985). The pain system. The neural basis of nociceptive transmission in the mammalian nervous system. Basel: Karger.
169.
Willis WD (1997). Nociceptive functions of thalamic neurons. In: Thalamus. Steriade M, Jones EG, McCormick DA, editors. Oxford: Elsevier Science.
170.
Woda A., Navez ML, Picard P., Gremeau C., Pichard-Leandri E. (1998). A possible therapeutic solution for stomatodynia (burning mouth syndrome). J Orofac Pain12:272-278.
171.
Xu XP, Fukuyama H., Yazawa S., Mima T., Hanakawa T., Magata Y., et al. (1997). Functional localization of pain perception in the human brain studied by PET. Neuroreport8:555-559.
172.
Zegarelli DJ (1984). Burning mouth: an analysis of 57 patients. Oral Surg Oral Med Oral Pathol58:34-38.
