There is substantial need for the replacement of tissues in the craniofacial complex due to congenital defects, disease, and injury. The field of tissue engineering, through the application of engineering and biological principles, has the potential to create functional replacements for damaged or pathologic tissues. Three main approaches to tissue engineering have been pursued: conduction, induction by bioactive factors, and cell transplantation. These approaches will be reviewed as they have been applied to key tissues in the craniofacial region. While many obstacles must still be overcome prior to the successful clinical restoration of tissues such as skeletal muscle and the salivary glands, significant progress has been achieved in the development of several tissue equivalents, including skin, bone, and cartilage. The combined technologies of gene therapy and drug delivery with cell transplantation will continue to increase treatment options for craniofacial cosmetic and functional restoration.
References
1.
Aframian DJ, Cukierman E., Nikolovski J., Mooney DJ, Yamada KM, Baum BJ ( 2000). The growth and morphological behavior of salivary epithelial cells on matrix protein-coated biodegradable substrata. Tissue Eng6:209-216.
2.
Aigner J., Tegeler J., Hutzler P., Campoccia D., Pavesio A., Hammer C., et al. (1998). Cartilage tissue engineering with novel nonwoven structured biomaterial based on hyaluronic acid benzyl ester. J Biomed Mater Res42:172-181.
3.
Alsberg E., Rowley JA, Shea LD, Liao EE, Franceschi RT, Mooney DJ (1999). Injectable hydrogels with covalently linked peptides for bony tissue development (abstract). J Dent Res78(Spec Iss):218.
4.
Anseth KS, Shastri VR, Langer R. (1999). Photopolymerizable degradable polyanhydrides with osteocompatibility. Nat Biotechnol17:156-159.
5.
Aydelotte MB, Thonar EJ, Mollenhauer J., Flechtenmacher J. (1998). Culture of chondrocytes in alginate gel: variations in conditions of gelation influence the structure of the alginate gel, and the arrangement and morphology of proliferating chondrocytes. In Vitro Cell Dev Biol Anim34: 123-130.
6.
Beekman B., Verzijl N., Bank RA, von der Mark K., TeKoppele JM (1997). Synthesis of collagen by bovine chondrocytes cultured in alginate: posttranslational modifications and cell-matrix interaction. Exp Cell Res237:135-141.
7.
Bell E., Ehrlich HP, Buttle DJ, Nakatsuji T. (1981). Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science211:1052-1054.
8.
Bennett S., Connolly K., Lee DR, Jiang Y., Buck D., Hollinger JO, et al. (1996). Initial biocompatibility studies of a novel degradable polymeric bone substitute that hardens in situ. Bone19:101S-107S.
9.
Bentley G., Greer RB (1971). Homotransplantation of isolated epiphyseal and articular cartilage chondrocytes into joint surfaces of rabbits. Nature230:385-388.
10.
Berthod F. Damour O. (1997). In vitro reconstructed skin models for wound coverage in deep burns. Br J Dermatol136:809-816.
11.
Beumer GJ, van Blitterswijk CA, Ponec M. (1994). Biocompatibility of a biodegradable matrix used as a skin substitute: an in vivo evaluation. J Biomed Mater Res28:545-552.
12.
Black AF, Berthod F., L'Heureux N., Germain L., Auger FA (1998). In vitro reconstruction of a human capillary-like network in a tissue- engineered skin equivalent. FASEB J12:1331-1340.
13.
Boyne PI, Marx RE, Nevins M., Triplett G., Lazaro E., Lilly LC, et al. (1997). A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodont Rest Dent17:11-25.
14.
Breier G., Risau W. (1996). The role of vascular endothelial growth factor in blood vessel formation. Trends Cell Biol6:454-456.
15.
Breitbart AS, Grande DA, Kessler R., Ryaby IT, Fitzsimmons RJ, Grant RT (1998). Tissue engineered bone repair of calvarial defects using cultured periosteal cells. Plast Reconstr Surg101:567-574; discussion 575-566.
16.
Breitbart AS, Grande DA, Mason JM, Barcia M., James T., Grant RT (1999). Gene-enhanced tissue engineering: applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene. Ann Plast Surg42:488-495.
17.
Brittberg M., Faxen E., Peterson L. (1994a). Carbon fiber scaffolds in the treatment of early knee osteoarthritis. A prospective 4-year followup of 37 patients. Clin Orthop307:155-164.
18.
Brittberg M., Lindahl A., Nilsson A., Ohlsson C., isaksson O., Peterson L. (1994b). Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation I see comments]. N Engl J Med331:889-895.
19.
Brittberg M., Nilsson A., Lindahl A., Ohlsson C., Peterson L. (1996). Rabbit articular cartilage defects treated with autologous cultured chondrocytes. Clin Orthop326:270-283.
20.
Bujia J., Sittinger M., Minuth WW, Hammer C., Burmester G., Kastenbauer E. (1995). Engineering of cartilage tissue using bioresorbable polymer fleeces and perfusion culture. Acta Otolaryngol (Stockh)115:307-310.
21.
Buschmann MD, Gluzband YA, Grodzinsky AJ, Kimura JH, Hunziker EB (1992). Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix. J Orthop Res10:745-758.
22.
Cairns BA, deSerres S., Peterson HD, Meyer AA (1993). Skin replacements. The biotechnological quest for optimal wound closure. Arch Surg128:1246-1252.
23.
Campbell CJ, Ishida H., Takahashi H., Kelly F. (1963). The transplantation of articular cartilage. J Bone Joint Surg45(A):1579-1592.
24.
Canalis E. (1996). Regulation of bone remodeling. In: Primer on the metabolic bone diseases and disorders of mineral metabolism. Favus MJ, editor. Philadelphia, PA: Lippincott-Raven, pp. 29-34.
25.
Cao Y., Vacanti JP, Paige KT, Upton J., Vacanti CA (1997). Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear [see comments]. Plast Reconstr Surg100:297-302; discussion 303-294.
26.
Chesterman PJ, Smith AU (1968). Homotransplantation of articular cartilage and isolated chondrocytes. An experimental study in rabbits. J Bone Joint Surg [Br]50:184-197.
27.
Chu CR, Coutts RD, Yoshioka M., Harwood FL, Monosov AZ, Amiel D. (1995a). Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study. J Biomed Mater Res29:1147-1154.
28.
Chu CR, Monosov AZ, Amiel D. (1995b). In situ assessment of cell viability within biodegradable polylactic acid polymer matrices. Biomaterials16:1381-1384.
29.
Cochran DL, Wozney JM (1999). Biological mediators for periodontal regeneration. Periodontology 200019:40-58.
30.
Constantz BR, Ison IC, Fulmer MT, Poser RD, Smith ST, VanWagoner M., et al. (1995). Skeletal repair by in situ formation of the mineral phase of bone [see comments]. Science267:1796-1799.
31.
Cooper ML, Spielvogel RL (1994). Artificial skin for wound healing. Clin Dermatol12:183-191.
32.
Dagalakis N., Flink J., Stasikelis P., Burke JF, Yannas IV (1980). Design of an artificial skin. Part III. Control of pore structure. J Biomed Mater Res14:511-528.
33.
de Chalain T., Phillips JH, Hinek A. (1999). Bioengineering of elastic cartilage with aggregated porcine and human auricular chondrocytes and hydrogels containing alginate, collagen, and K-elastin. J Biomed Mater Res44:280-288.
34.
de Luca M., Albanese E., Megna M., Cancedda R., Mangiante PE, Cadoni A., et al. (1990). Evidence that human oral epithelium reconstituted in vitro and transplanted onto patients with defects in the oral mucosa retains properties of the original donor site. Transplantation50:454-459.
35.
Delporte C., O'Connell BC, He X., Lancaster HE, O'Connell AC, Agre P., et al. (1997). Increased fluid secretion after adenoviralmediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci USA94:3268-3273.
36.
Dougherty WR, Chalabian JR (1995). Skin substitutes. West J Med162:540-541.
37.
Eaglstein WH (1998). Dermagraft treatment of diabetic ulcers. J Dermatol25:803-804.
38.
Eggli PS, Muller W., Schenk RK (1988). Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits. A comparative histomorphometric and histologic study of bony ingrowth and implant substitution. Clin Orthop232:127-138.
39.
El-Ghannam A., Ducheyne P., Shapiro IM (1997). Porous bioactive glass and hydroxyapatite ceramic affect bone cell function in vitro along different time lines. J Biomed Mater Res36:167-180.
40.
Elgendy HM, Norman ME, Keaton AR, Laurencin CT (1993). Osteoblast-like cell (MC3T3-E1) proliferation on bioerodible polymers: an approach towards the development of a bone-bioerodible polymer composite material. Biomaterials14:263-269.
41.
Eming SA, Medalie DA, Tompkins RG, Yarmush ML, Morgan JR (1998). Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft. Hum Gene THer9:529-539.
42.
Fang J. Zhu YY, Smiley E., Bonadio J., Rouleau JP, Goldstein SA, et al. (1996). Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proc Natl Acad Sci USA93:5753-5758.
43.
Fox PC (1998). Acquired salivary dysfunction. Drugs and radiation. Ann NY Acad Sci842:132-137.
44.
Freed LE, Vunjak-Novakovic G. (1995). Tissue engineering of cartilage. In: The biomedical engineering handbook. Bronzino JD, editor. Boca Raton, FL: CRC Press, pp. 1788-1806.
45.
Freed LE, Marquis JC, Nohria A., Emmanual J., Mikos AG, Langer R. (1993). Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res27:11-23.
46.
Freed LE, Grande DA, Lingbin Z., Emmanual J., Marquis JC, Langer R. (1994). Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. J Biomed Mater Res28:891-899.
47.
Friedman CD, Costantino PD, Takagi S., Chow LC ( 1998). BoneSource hydroxyapatite cement: a novel biomaterial for craniofacial skeletal tissue engineering and reconstruction. J Biomed Mater Res43:428-432.
48.
Fujisato T., Sajiki T., Liu Q., Ikada Y. (1996). Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold. Biomaterials17:155-162.
49.
Ghosh MM, Boyce S., Layton C., Freedlander E., MacNeil S. (1997). A comparison of methodologies for the preparation of human epidermal-dermal composites. Ann Plast Surg39:390-404.
50.
Giannobile WV (1996). Periodontal tissue engineering by growth factors. Bone19:23S-37S.
51.
Goshima J., Goldberg VM, Caplan AI (1991a). The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop269:274-283.
52.
Goshima J., Goldberg VM, Caplan A.l (1991b). The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin Orthop262:298-311.
53.
Grande DA, Pitman MI, Peterson L., Menche D., Klein M. (1989). The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. J Orthop Res7:208-218.
54.
Green H., Kehinde O., Thomas J. (1979). Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci USA76:5665-5668.
55.
Green WT Jr (1977). Articular cartilage repair. Behavior of rabbit chondrocytes during tissue culture and subsequent allografting. Clin Orthop124:237-250.
56.
Gruber HE, Stasky AA, Hanley EN Jr (1997). Characterization and phenotypic stability of human disc cells in vitro. Matrix Biol16:285-288.
57.
Hansbrough JF, Cooper ML, Cohen R., Spielvogel R., Greenleaf G., Bartel RL, et al. (1992). Evaluation of a biodegradable matrix containing cultured human fibroblasts as a dermal replacement beneath meshed skin grafts on athymic mice. Surgery111:438-446.
58.
Hansbrough JF, Mozingo DW, Kealey GP, Davis M., Gidner A., Gentzkow GD (1997). Clinical trials of a biosynthetic temporary skin replacement, Dermagraft-Transitional Covering, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. J Burn Care Rehabil18:43-51.
59.
Hardwick R., Scantlebury TV, Sanchez R., Whitley N., Ambruster J. (1994). Membrane design criteria for guided bone regeneration of the alveolar ridge. In: Guided bone regeneration in implant dentistry. Buser D, Dahlin C, Schenk RK, editors. Chicago, IL: Quintessence Publishing, pp. 101-136.
60.
Heijl L., Heden G., Svardstrom G., Ostgren A. (1997). Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol24:705-714.
61.
Hendrickson DA, Nixon AI, Grande DA, Todhunter RJ, Minor RM, Erb H., et al. (1994). Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res12:485-497.
62.
Hermann JS, Buser D. (1996). Guided bone regeneration for dental implants. Curr Opin Periodontol3:168-177.
63.
Holder WD, Gruber HE, Roland WD, Moore AL, Culberson CR, Loebsack AB, et al. (1997). Increased vascularization and heterogeneity of vascular structures occurring in polyglycolide matrices containing aortic endothelial cells implanted in the rat. Tissue Eng3:149-160.
64.
Homminga GN, Buma P., Koot HW, van der Kraan PM, van den Berg WB (1993). Chondrocyte behavior in fibrin glue in vitro. Acta Orthop Scand64:441-445.
65.
Howell TH, Fiorellini JP, Paquette DW, Offenbacher S., Giannobile WV, Lynch SE (1997). A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol68: 1186-1193.
66.
Ingber D. (1991). Integrins as mechanochemical transducers. Curr Opin Cell Biol3:841-848.
67.
Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG (1997). Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. I Biomed Mater Res36:17-28.
68.
Ishaug-Riley SL, Crane GM, Gurlek A., Miller MJ, Yasko AW, Yaszemski MJ, et al. (1997). Ectopic bone formation by marrow stromal osteoblast transplantation using poly(DL-lactic-co-glycolic acid) foams implanted into the rat mesentery. I Biomed Mater Res36:1-8.
69.
Isogai N., Landis W., Kim TH, Gerstenfeld LC, Upton J., Vacanti JP (1999). Formation of phalanges and small joints by tissue-engineering. J Bone Joint Surg Am81:306-316.
70.
Itay S., Abramovici A., Nevo Z. ( 1987). Use of cultured embryonal chick epiphyseal chondrocytes as grafts for defects in chick articular cartilage. Clin Orthop220:284-303.
71.
Iyoda K., Miura T., Nogami H. (1993). Repair of bone defect with cultured chondrocytes bound to hydroxyapatite. Clin Orthop288:287-293.
72.
Iee WSS (1987). The skeletal tissues. In: Histology: cell and tissue biology. Weiss L, editor. New York, NY: Elsevier Biomedical, pp. 212-254.
73.
Kim BS, Putnam AJ, Kulik TJ, Mooney DJ (1998). Optimizing seeding and culture methods to engineer smooth muscle tissue on biodegradable polymer matrices. Biotechnol Bioeng57:46-54.
74.
Kim BS, Nikolovski J., Bonadio J., Smiley E., Mooney DJ (1999). Engineered smooth muscle tissues: regulating cell phenotype with the scaffold. Exp Cell Res251:318-328.
75.
Kim WS, Vacanti JP, Cima L., Mooney D., Upton J., Puelacher WC, et al. (1994a). Cartilage engineered in predetermined shapes employing cell transplantation on synthetic biodegradable polymers. Plast Reconstr Surg94:233-237; discussion 238-240.
76.
Kim WS, Vacanti CA, Upton J., Vacanti JP (1994b). Bone defect repair with tissue-engineered cartilage. Plast Reconstr Surg94:580-584.
77.
Lamme EN, van Leeuwen RT, Jonker A., van Marle J., Middelkoop E. (1998). Living skin substitutes: survival and function of fibroblasts seeded in a dermal substitute in experimental wounds. J Invest Dermatol111:989-995.
78.
Langer R. (1990). New methods of drug delivery. Science249:1527-1533.
79.
Langer R., Vacanti JP (1993). Tissue engineering. Science260:920-926.
80.
Laurencin CT, Attawia MA, Elgendy HE, Herbert KM (1996). Tissue engineered bone-regeneration using degradable polymers: the formation of mineralized matrices. Bone19:93S-99S.
81.
Lindenhayn K., Perka C., Spitzer RS, Heilmann HH, Pommerening K., Mennicke J., et al. (1999). Retention of hyaluronic acid in alginate beads: aspects for in vitro cartilage engineering. J Biomed Mater Res44:149-155.
82.
Livesey SA, Herndon DN, Hollyoak MA, Atkinson YH, Nag A. (1995). Transplanted acellular allograft dermal matrix. Potential as a template for the reconstruction of viable dermis. Transplantation60:1-9.
83.
Ma PX, Langer R. (1999). Morphology and mechanical function of long-term in vitro engineered cartilage. J Biomed Mater Res44:217-221.
84.
Ma PX, Schloo B., Mooney D., Langer R. (1995). Development of biomechanical properties and morphogenesis of in vitro tissue engineered cartilage. J Biomed Mater Res29:1587-1595.
85.
McEwen DR, Sanchez MM (1997). A guide to salivary gland disorders. AORN J65:554-556, 559-567; quiz 568-559, 571-552.
86.
Messner K. (1993). Hydroxyapatite supported Dacron plugs for repair of isolated full-thickness osteochondral defects of the rabbit femoral condyle: mechanical and histological evaluations from 6-48 weeks. J Biomed Mater Res27:1527-1532.
87.
Messner K., Gillquist J. (1993). Synthetic implants for the repair of osteochondral defects of the medial femoral condyle: a biomechanical and histological evaluation in the rabbit knee. Biomaterials14:513-521.
88.
Messner K., Lohmander LS, Gillquist J. (1993). Neocartilage after artificial cartilage repair in the rabbit: histology and proteoglycan fragments in joint fluid. J Biomed Mater Res27:949-954.
89.
Mizuno H., Emi N., Abe A., Takahashi I., Kojima T., Saito H., et al. (1999). Successful culture and sustainability in vivo of gene-modified human oral mucosal epithelium. Hum Gene Ther10:825-830.
90.
Mohamed-Ali V., Pinkney JH, Coppack SW (1998). Adipose tissue as an endocrine and paracrine organ. Int J Obes Relat Metab Disord22:1145-1158.
91.
Mooney DJ, Mikos AG (1999). Growing new organs. Scientif Am280:60-65.
92.
Mooney DJ, Rowley JA (1997). Tissue engineering: integrating cells and materials to create functional tissue replacements. In: Controlled drug delivery: challenges and strategies. Park K, editor. Washington, DC: ACS, pp. 333-346.
93.
Mooney DJ, Park S., Kaufmann PM, Sano K., McNamara K., Vacanti JP, et al. (1995). Biodegradable sponges for hepatocyte transplantation. J Biomed Mater Res29:959-965.
94.
Nixon AJ, Sams AE, Lust G., Grande D., Mohammed HO (1993). Temporal matrix synthesis and histologic features of a chondrocyte-laden porous collagen cartilage analogue. Am J Vet Res54:349-356.
95.
Noguchi T., Oka M., Fujino M., Neo M., Yamamuro T. (1994). Repair of osteochondral defects with grafts of cultured chondrocytes. Comparison of allografts and isografts. Clin Orthop302:251-258.
96.
Nor JE, Christensen J., Mooney DJ, Polverini PJ (1999). Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl- 2 expression. Am J Pathol154:375-384.
97.
Ohura K., Hamanishi C., Tanaka S., Matsuda N. (1999). Healing of segmental bone defects in rats induced by a β-TCP-MCPM cement combined with rhBMP-2. J Biomed Mater Res44:168-175.
98.
Okano T., Matsuda T. (1998). Tissue engineered skeletal muscle: preparation of highly dense, highly oriented hybrid muscular tissues. Cell Transplant7:71-82.
99.
Oonishi H., Kushitani S., Yasukawa E., Iwaki H., Hench LL, Wilson J., et al. (1997). Particulate bioglass compared with hydroxyapatite as a bone graft substitute. Clin Orthop334:316-325.
100.
Opas M. ( 1989). Expression of the differentiated phenotype by epithelial cells in vitro is regulated by both biochemistry and mechanics of the substratum. Dev Biol131:281-293.
Paige KT, Cima LG, Yaremchuk MJ, Schloo BL, Vacanti JP, Vacanti CA (1996). De novo cartilage generation using calcium alginate-chondrocyte constructs. Plast Reconstr Surg97:168-178; discussion 179-180.
103.
Pandit A., Ashar R., Feldman D., Thompson A. (1998). Investigation of acidic fibroblast growth factor delivered through a collagen scaffold for the treatment of full-thickness skin defects in a rabbit model. Plast Reconstr Surg101:766-775.
104.
Parenteau N. (1999). Skin: the first tissue-engineered products. Scientif Am280:83-84.
105.
Parsons JR (1985). Resorbable materials and composites. New concepts in orthopedic biomaterials. Orthopedics8:907-915.
106.
Pedersen RA (1999). Embryonic stem cells for medicine. Scientif Am280:68-73.
107.
Peltier LF, Jones RH (1978). Treatment of unicameral bone cysts by curettage and packing with plaster-of-Paris pellets. J Bone Joint Surg [Am]60:820-822.
108.
Peppas NA, Langer R. (1994). New challenges in biomaterials [see comments]. Science263:1715-1720.
109.
Peter SJ, Miller ST, Zhu G., Yasko AW, Mikos AG (1998). In vivo degradation of a poly(propylene fumarate)/beta-tricalcium phosphate injectable composite scaffold. J Biomed Mater Res41:1-7.
110.
Petrosko P., Acarturk TO, Dimilla PA, Johnson PC (1998). Muscle tissue engineering. In: Frontiers in tissue engineering. Patrick CWJ, Mikos AG, McIntire LV, editors. New York, NY: Elsevier Science, Ltd., pp. 495-513.
111.
Phillips TJ (1998). New skin for old: developments in biological skin substitutes [editorial; comment]. Arch Dermatol134:344-349.
112.
Piskin E., Atac AG ( 1996). Glow-discharge-modified activated carbon cloths as skin substitutes. J Biomed Mater Res30:493-499.
113.
Powell C., Shansky J., Del Tatto M., Forman DE, Hennessey J., Sullivan K., et al. (1999). Tissue-engineered human bioartificial muscles expressing a foreign recombinant protein for gene therapy. Hum Gene Ther10:565-577.
114.
Pruitt BA Jr (1997). The evolutionary development of biologic dressings and skin substitutes. J Burn Care Rehabil18:S2-5.
115.
Puelacher WC, Kim SW, Vacanti JP, Schloo B., Mooney D., Vacanti CA (1994a). Tissue-engineered growth of cartilage: the effect of varying the concentration of chondrocytes seeded onto synthetic polymer matrices [see comments]. Int J Oral Maxillofac Surg23:49-53.
116.
Puelacher WC, Mooney D., Langer R., Upton J., Vacanti JP, Vacanti CA (1994b). Design of nasoseptal cartilage replacements synthesized from biodegradable polymers and chondrocytes. Biomaterials15:774-778.
117.
Puelacher WC, Wisser J., Vacanti CA, Ferraro NF, Jaramillo D., Vacanti JP (1994c). Temporomandibular joint disc replacement made by tissue-engineered growth of cartilage. J Oral Maxillofac Surg52:1172-1177; discussion 1177-1178.
118.
Puelacher WC, Vacanti JP, Ferraro NF, Schloo B., Vacanti CA (1996). Femoral shaft reconstruction using tissue-engineered growth of bone. Int J Oral Maxillofac Surg25:223-228.
119.
Putnam AJ, Mooney DJ (1996). Tissue engineering using synthetic extracellular matrices. Nat Med2:824-826.
120.
Radder AM, Leenders H., van Blitterswijk CA (1996). Application of porous PEO/PBT copolymers for bone replacement. J Biomed Mater Res30:341-351.
121.
Rhee PH, Friedman CD, Ridge JA, Kusiak J. (1998). The use of processed allograft dermal matrix for intraoral resurfacing: an alternative to split-thickness skin grafts. Arch Otolaryngol Head Neck Surg124:1201-1204.
122.
Ripamonti U. (1991). The morphogenesis of bone in replicas of porous hydroxyapatite obtained from conversion of calcium carbonate exoskeletons of coral. J Bone Joint Surg [Am]73:692-703.
123.
Ripamonti U., Duneas N. (1996). Tissue engineering of bone by osteoinductive biomaterials. MRS Bull November:36-39.
124.
Robinson BP, Hollinger JO, Szachowicz EH, Brekke J. (1995). Calvarial bone repair with porous D,L-polylactide. Otolaryngol Head Neck Surg112:707-713.
125.
Robinson D., Halperin N., Nevo Z. ( 1990). Regenerating hyaline cartilage in articular defects of old chickens using implants of embryonal chick chondrocytes embedded in a new natural delivery substance. Calcif Tissue Int46:246-253.
126.
Rodriguez AM, Vacanti CA (1998). Tissue engineering of cartilage. In: Frontiers in tissue engineering. Patrick CWJ, MikosAG, McIntireLV, editors. New York, NY: Elsevier Science, Ltd., pp. 400-411.
127.
Rotter N., Aigner J., Naumann A., Planck H., Hammer C., Burmester G., et al. (1998). Cartilage reconstruction in head and neck surgery: comparison of resorbable polymer scaffolds for tissue engineering of human septal cartilage. J Biomed Mater Res42:347-356.
128.
Rouabhia M., Germain L., Bergeron J., Auger FA (1995). Allogeneicsyngeneic cultured epithelia. A successful therapeutic option for skin regeneration. Transplantation59:1229-1235.
129.
Shea LD, Smiley E., Bonadio J., Mooney DJ (1999). DNA delivery from polymer matrices for tissue engineering [see comments ]. Nat Biotechnol17:551-554.
130.
Shea LD, Wang D., Franceschi RT, Mooney DJ (2000). Engineered bone development from pre-osteoblasts cultured on 3-dimensional biodegradable scaffolds. Tissue Eng6:605-617.
131.
Sheridan MH, Shea LD, Peters MC, Mooney DJ Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J Controlled Rel64:91-102.
132.
Sims CD, Butler PE, Casanova R., Lee BT, Randolph MA, Lee WP, et al. (1996). Injectable cartilage using polyethylene oxide polymer substrates. Plast Reconstr Surg98:843-850.
133.
Sims CD, Butler PE, Cao YL, Casanova R., Randolph MA, Black A., et al. (1998). Tissue engineered neocartilage using plasma derived polymer substrates and chondrocytes. Plast Reconstr Surg101:1580-1585.
134.
Sittinger M., Reitzel D., Dauner M., Hierlemann H., Hammer C., Kastenbauer E., et al. (1996). Resorbable polyesters in cartilage engineering: affinity and biocompatibility of polymer fiber structures to chondrocytes. J Biomed Mater Res33:57-63.
135.
Smith SK, Karst NS (2000). Head & neck histology and anatomy: a self-instructional program. Stamford, CT: Appleton & Lange.
136.
Solchaga LA, Dennis JE, Goldberg VM, Caplan A.l (1999). Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage. J Orthop Res17:205-213.
137.
Stix G. ( 1997). Growing a new field [news]. Scientif Am277:15-16.
138.
Strohman RC, Bayne E., Spector D., Obinata T., Micou-Eastwood J., Maniotis A. (1990). Myogenesis and histogenesis of skeletal muscle on flexible membranes in vitro. In Vitro Cell Dev Biol26:201-208.
139.
Su CH, Sun CS, Juan SW, Ho HO, Hu CH, Sheu MT ( 1999). Development of fungal mycelia as skin substitutes: effects on wound healing and fibroblast. Biomaterials20:61-68.
140.
Tabata Y., Yamada K., Miyamoto S., Nagata I., Kikuchi H., Aoyama I., et al. (1998). Bone regeneration by basic fibroblast growth factor complexed with biodegradable hydrogels. Biomaterials19:807-815.
141.
Tamura RN, Oda D., Quaranta V., Plopper G., Lambert R., Glaser S., et al. (1997). Coating of titanium alloy with soluble laminin-5 promotes cell attachment and hemidesmosome assembly in gingival epithelial cells: potential application to dental implants. J Periodont Res32:287-294.
142.
Tardy MEJ, Kastenbauer ER (1995). Head and neck surgery, Vol. I. 2nd rev. ed. New York, NY: Thieme Medical Publishers, Inc.
143.
Teumer J., Hardin-Young J., Parenteau NL (1998). Tissue engineered skin. In: Frontiers in tissue engineering. Patrick CWJ, Mikos AG, McIntire LV, editors. New York, NY: Elsevier Science, Ltd., pp. 664-677.
144.
Ting V., Sims CD, Brecht LE, McCarthy JG, Kasabian AK, Connelly PR, et al. (1998). In vitro prefabrication of human cartilage shapes using fibrin glue and human chondrocytes. Ann Plast Surg40:413-420; discussion 420-411.
145.
Ueda M., Hata K., Sumi Y., Mizuno H., Niimi A. (1998). Peri-implant soft tissue management through use of cultured mucosal epithelium. Oral Surg Oral Med Oral Path Oral Radiol Endodont86:393-400.
146.
Vacanti CA, Langer R., Schloo B., Vacanti JP (1991). Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation. Plast Reconstr Surg88:753-759.
147.
Vacanti CA, Kim W., Schloo B., Upton J., Vacanti JP (1994). Joint resurfacing with cartilage grown in situ from cell-polymer structures. Am J Sports Med22:485-488.
148.
Vandenburgh HH, Swasdison S., Karlisch P. (1991). Computer-aided mechanogenesis of skeletal muscle organs from single cells in vitro. FASEB J5:2860-2867.
149.
von Schroeder HP, Kwan M., Amiel D., Coutts RD (1991). The use of polylactic acid matrix and periosteal grafts for the reconstruction of rabbit knee articular defects [published erratum appears in J Biomed Mater Res 26:following 553, 1992]. J Biomed Mater Res25:329-339.
150.
Wachtel HC, Langford A., Bernimoulin JP, Reichart P. (1991). Guided bone regeneration next to osseointegrated implants in humans. Int J Oral Maxillofac Implants6:127-135.
151.
Wainwright DJ (1995). Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns21:243-248.
152.
Wakitani S., Kimura T., Hirooka A., Ochi T., Yoneda M., Yasui N., et al. (1989). Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel. J Bone Joint Surg [Br]71:74-80.
153.
Wakitani S., Goto T., Pineda SJ, Young RG, Mansour JM, Caplan AI, et al. (1994). Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am76:579-592.
154.
Wakitani S., Goto T., Young RG, Mansour JM, Goldberg VM, Caplan AI (1998). Repair of large full-thickness articular cartilage defects with allograft articular chondrocytes embedded in a collagen gel. Tissue Eng4:429-444.
155.
Whang K., Tsai DC, Nam EK, Aitken M., Sprague SM, Patel PK, et al. (1998). Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. J Biomed Mater Res42:491-499.
156.
Whang K., Healy KE, Elenz DR, Nam EK, Tsai DC, Thomas CH, et al. (1999). Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture. Tissue Eng5:35-51.
157.
Williams PL, Warwick R., Dyson M., Bannister LH (1989). Gray's anatomy. New York, NY: Churchill Livingstone.
158.
Yannas IV (1995). Artificial skin and dermal equivalents. In: The biomedical engineering handbook. Bronzino ID, editor. Boca Raton, FL: CRC Press, pp. 2025-2038.
159.
Yannas IV, Burke JF (1980). Design of an artificial skin. I. Basic design principles. J Biomed Mater Res14:65-81.
160.
Yannas IV, Burke JF, Gordon PL, Huang C., Rubenstein RH (1980). Design of an artificial skin. II. Control of chemical composition. J Biomed Mater Res14:107-132.
161.
Yasko AW, Lane JM, Fellinger EJ, Rosen V., Wozney JM, Wang EA ( 1992). The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats [published erratum appears in J Bone Joint Surg Am 74:1111, 1992]. J Bone Joint Surg Am74:659-670.
162.
Yaszemski MJ, Yasko AW (1998). Musculoskeletal tissue engineering for orthopedic surgical applications. In: Frontiers in tissue engineering. Patrick CWJ, Mikos AG, McIntire LV, editors. New York, NY: Elsevier Science, Ltd., pp. 197-212.
163.
Yaszemski MJ, Payne RG, Hayes WC, Langer R., Mikos AG (1996). Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone. Biomaterials17:175-185.
164.
Zacchi V., Soranzo C., Cortivo R., Radice M., Brun P., Abatangelo G. (1998). In vitro engineering of human skin-like tissue. J Biomed Mater Res40:187-194.
