This article explores 100 years of interprofessional practice and education (IPE) through the archives of Families and Society: The Journal of Contemporary Social Services. A journal-specific archival and systematic review employing quantitative and qualitative methods identifies early references to, and frequency of, terms and meanings associated with IPE; examines meanings associated with terms describing interprofessional interactions; and explores related contexts, settings, and populations served. Articles were searched using key terms from two scoping IPE reviews and narrowed based on inclusion and exclusion criteria. An Excel© spreadsheet was prepared using descriptive, qualitative, and coded items. Findings revealed early references to IPE-related concepts, an expanded list of classifications and descriptions of interprofessional interactions, and an extensive list of practice settings and populations served through IPE-related activities. Implications for social work education, practice, policy, and research are addressed.