Survivors of central nervous system tumors (SCNST) are a growing group of cancer survivors who require risk-based, long-term health care due to the chemotherapy, surgery, and radiation they have received.Although treatment strategies are being developed to reduce morbidity and mortality, ultimately this subgroup of pediatric cancer survivors often faces moderate to severe late effects of their treatment.As a result, they will need lifelong health care that includes risk-based health care due to cancer treatment exposures as well as primary adult health care, including primary and secondary preventative care. The best way to accomplish lifelong health care for SCNST as they enter adulthood is not clearly defined. In this article, the authors plan to (1) present an overview of the complexities of health care problems that make transition challenging for SCNST; (2) review the evolving transition literature; (3) explore the barriers to successful transition; (4) discuss methods to facilitate transition; (5) describe approaches, strategies, and models for survivorship care in SCNST; (6) present issues for consideration when transitioning SCNST; and (7) provide information on transition-related resources.
American Academy of Pediatrics, Committee on Children with Disabilities and Committee on Adolescence. (1996). Transition of care provided for adolescents with special health care needs. Pediatrics, 98(6, Pt. 1), 1203-1206.
3.
Anderson, F.S., & Kunin-Batson, A.S. (2009). Neurocognitive late effects of chemotherapy in children: The past 10 years of research on brain structure and function. Pediatric Blood & Cancer, 52, 159-164.
Benesch M., Lackner H., Sovinz P., et al. (2006). Late sequela after treatment of childhood low-grade gliomas: a retrospective analysis of 69 long-term survivors treated between 1983 and 2003. Journal of Neuro-Oncology. 78: 199-205.
6.
Betz, C.L. ( 1998). Facilitating the transition of adolescents with chronic conditions from pediatric to adult health care and community settings . Issues in Comprehensive Pediatric Nursing, 21, 97-115.
7.
Binks, J.A., Barden, W.S., Burke, T.A., & Young, N.L. ( 2007). What do we really know about the transition to adult-centered health care? A focus on cerebral palsy and spina bifida. Archives of Physical Medicine & Rehabilitation, 88, 1064-1073.
8.
Blaauwbroek, R., Tuinier, W., Meyboom-de Jong, B., Kamps, W.A., & Postma, A. ( 2008). Shared care by paediatric oncologists and family doctors for long-term follow-up of adult childhood cancer survivors: A pilot study . Lancet Oncology, 9, 232-238.
9.
Blum, R.W. ( 1995). Transition to adult health care: Setting the stage . Journal of Adolescent Health, 17, 3-5.
10.
Blum, R.W. ( 2002). Introduction. Improving transition for adolescents with special health care needs from pediatric to adult-centered health care . Pediatrics, 110(6, Pt. 2), 1301-1303.
11.
Blum, R.W., Garell, D., Hodgman, C.H., Jorissen, T.W., Okinow, N.A., Orr, D.P., et al. (1993). Transition from child-centered to adult health-care systems for adolescents with chronic conditions. A position paper of the Society for Adolescent Medicine. Journal of Adolescent Health, 14, 570-576.
12.
Bowers, D.C., Liu, Y., Leisenring, W., McNeil, E., Stovall, M., Gurney, J.G., (2006). Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol, 24(33), 5277-5282.
13.
Brougham, M.F., Kelnar, C.J., & Wallace, W.H. ( 2002). The late endocrine effects of childhood cancer treatment . Pediatric Rehabilitation, 5, 191-201.
14.
Brydoy, M., Fossa, S.D., Dahl, O., & Bjoro, T. ( 2007). Gonadal dysfunction and fertility problems in cancer survivors. Acta Oncologica, 46, 480-489.
15.
Callahan, S.T., Winitzer, R.F., & Keenan, P. ( 2001). Transition from pediatric to adult-oriented health care: A challenge for patients with chronic disease. Current Opinion in Pediatrics, 13, 310-316.
16.
Carroll, G., Massarelli, E., Opzoomer, A., Pekeles, G., Pedneault, M., Frappier, J.Y., et al. (1983). Adolescents with chronic disease. Are they receiving comprehensive health care? J Adolesc Health Care , 4(4), 261-265.
17.
Cassidy, L., Stirling, R., May, K., Picton, S., & Doran, R. (2000). Ophthalmic complications of childhood medulloblastoma. Medical and Pediatric Oncology, 34, 43-47. Cohen, L. E. (2003). Endocrine late effects of cancer treatment. Current Opinion in Pediatrics, 15, 3-9.
18.
Conklin, H.M., Li, C., Xiong, X., Ogg, R.J., & Merchant, T.E. (2008). Predicting change in academic abilities after conformal radiation therapy for localized ependymoma . Journal of Clinical Oncologist, 26, 3965-3970.
19.
Dickerman, J.D. ( 2007). The late effects of childhood cancer therapy. Pediatrics, 119(3), 554-568.
20.
Duffey-Lind, E.C., O’Holleran, E., Healey, M., Vettese, M., Diller, L., & Park, E.R. ( 2006). Transitioning to survivorship: A pilot study. Journal of Pediatric Oncology Nursing, 23, 335-343.
21.
Fox, A. ( 2002). Physicians as barriers to successful transitional care . International Journal of Adolescent Medicine and Health , 14, 3-7.
22.
Freyer, D.R., & Brugieres, L. ( 2008). Adolescent and young adult oncology: Transition of care . Pediatric Blood Cancer, 50(Suppl. 5), 1116-1119.
23.
Freyer, D.R., & Kibrick-Lazear, R. (2006). In sickness and in health: Transition of cancer-related care for older adolescents and young adults. Cancer, 107(Suppl. 7), 1702-1709.
24.
Garmey, E.G., Liu, Q., Sklar, C.A., Meacham, L.R., Mertens, A.C., Stovall, M.A., et al. (2008). Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol, 26(28), 4639-4645.
25.
Garwicz, S., Anderson, H., Olsen, J.H., Dollner, H., Hertz, H., Jonmundsson, G., et al. (2000). Second malignant neoplasms after cancer in childhood and adolescence: A population-based case-control study in the 5 Nordic countries. The Nordic Society for Pediatric Hematology and Oncology . The Association of the Nordic Cancer Registries. International Journal of Cancer, 88, 672-678.
26.
Geenen, M.M., Cardous-Ubbink, M.C., Kremer, L.C., van den Bos, C., van der Pal, H.J., Heinen, R.C., et al. (2007). Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. Journal of American Medical Association, 297, 2705-2715.
27.
Ginsberg, J.P., Hobbie, W.L., Carlson, C.A., & Meadows, A.T. ( 2006). Delivering long-term follow-up care to pediatric cancer survivors: Transitional care issues. Pediatric Blood Cancer , 46, 169-173.
28.
Gleeson, H.K., & Shalet, S.M. ( 2004). The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocrine-Related Cancer, 11, 589-602.
29.
Gordon, K.B., Char, D.H., & Sagerman, R.H. (1995). Late effects of radiation on the eye and ocular adnexa. International Journal of Radiation Oncology Biology Physics, 31, 1123-1139.
30.
Gurney, J.G., Kadan-Lottick, N.S., Packer, R.J., Neglia, J.P., Sklar, C.A., Punyko, J.A., et al. (2003). Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer, 97, 663-673.
31.
Heikens, J., Ubbink, M.C., van der Pal, H.P., Bakker, P.J., Fliers, E., Smilde, T.J., et al. (2000). Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. Cancer, 88(9), 2116-2121.
32.
Hoffman, B. ( 1999). Cancer survivors’ employment and insurance rights: A primer for oncologists. Oncology ( Williston Park), 13, 841-846.
33.
Hua, C., Bass, J.K., Khan, R., Kun, L.E., & Merchant, T.E. (2008). Hearing loss after radiotherapy for pediatric brain tumors: Effect of cochlear dose. International Journal of Radiation Oncology Biology Physics, 72, 892-899.
34.
Hudson, M.M., Hester, A., Sweeney, T., Kippenbrock, S., Majcina, R., Vear, S., et al. (2004). A model of care for childhood cancer survivors that facilitates research. Journal of Pediatric Oncology Nursing , 21, 170-174.
35.
Hudson, M.M., Mertens, A.C., Yasui, Y., Hobbie, W., Chen, H., Gurney, J.G., et al. (2003). Health status of adult long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Journal of American Medical Association, 290, 1583-1592.
36.
Inskip, P.D., & Curtis, R.E. ( 2007). New malignancies following childhood cancer in the United States, 1973-2002. International Journal of Cancer , 121, 2233-2240.
Jakacki, R.I., Goldwein, J.W., Larsen, R.L., Barber, G., & Silber, J.H. ( 1993). Cardiac dysfunction following spinal irradiation during childhood. Journal of Clinical Oncology, 11, 1033-1038.
39.
Jennison, M.H., Coleman, A.B., Feiertag, R.B., Kugel, R.B., Forsyth, W.B., Rinker, A. et al. (1972). Age limits of pediatrics. Pediatrics, 49, 463.
40.
Johannesen, T.B., Rasmussen, K., Winther, F.O., Halvorsen, U., & Lote, K. ( 2002). Late radiation effects on hearing, vestibular function, and taste in brain tumor patients. International Journal of Radiation Oncology Biology Physics, 53, 86-90.
41.
Kadan-Lottick, N.S., Robison, L.L., Gurney, J.G., Neglia, J.P., Yasui, Y., Hayashi, R., et al. (2002). Childhood cancer survivors' knowledge about their past diagnosis and treatment: Childhood Cancer Survivor Study. JAMA, 287(14), 1832-1839.
42.
Kavey, R.E., Allada, V., Daniels, S.R., Hayman, L.L., McCrindle, B.W., Newburger, J.W., et al. (2007). Cardiovascular risk reduction in high-risk pediatric patients: A scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research. Journal of Cardiovascular Nursing , 22, 218-253.
43.
Khan, R.B., Boop, F.A., Onar, A., & Sanford, R.A. ( 2006). Seizures in children with low-grade tumors: Outcome after tumor resection and risk factors for uncontrolled seizures. Journal of Neurosurgery, 104(Suppl. 6), 377-382.
44.
Khan, R.B., Hunt, D.L., Boop, F.A., Sanford, R.A., Merchant, T.E., Gajjar, A., et al. (2005). Seizures in children with primary brain tumors: Incidence and long-term outcome. Epilepsy Research , 64, 85-91.
45.
Khan, R.B., Marshman, K.C., & Mulhern, R.K. ( 2003). Atonic seizures in survivors of childhood cancer . Journal of Child Neurology, 18, 397-400.
46.
Kirsch, D.G., & Tarbell, N.J. ( 2004). New technologies in radiation therapy for pediatric brain tumors: The rationale for proton radiation therapy. Pediatric Blood Cancer, 42, 461-464.
47.
Laughton, S.J., Merchant, T.E., Sklar, C.A., Kun, L.E., Fouladi, M., Broniscer, A., et al. (2008). Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial. Journal of Clinical Oncology, 26, 1112-1118.
48.
Link, K., Moell, C., Garwicz, S., Cavallin-Stahl, E., Bjork, J., Thilen, U., et al. (2004). Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood . J Clin Endocrinol Metab, 89(10), 5003-5012.
49.
Litt, I.F. ( 1998). Age limits of pediatrics, American Academy of Pediatrics , Council on Child Health,Pediatrics , 1972;49:463. Pediatrics, 102(1 Pt 2), 249-250
50.
Luetjen, T., & Moore, W.V. ( 2005). Bone density after completion of growth hormone treatment for growth failure. Journal of Pediatric Endocrinology & Metabolism, 18, 1053-1061.
51.
Lustig, R.H., Post, S.R., Srivannaboon, K., Rose, S.R., Danish, R.K., Burghen, G.A., et al. (2003). Risk factors for the development of obesity in children surviving brain tumors. Journal of Clinical Endocrinology Metabolism, 88, 611-616.
52.
Maule, M., Scelo, G., Pastore, G., Brennan, P., Hemminki, K., Pukkala, E., et al. (2008). Risk of second malignant neoplasms after childhood central nervous system malignant tumours: An international study . European Journal of Cancer, 44, 830-839.
53.
McDonagh, J.E. ( 2005). Growing up and moving on: transition from pediatric to adult care. Pediatr Transplant, 9(3), 364-372.
54.
McDonagh, J.E. ( 2007). Transition of care from paediatric to adult rheumatology . Archives of Disease in Childhood, 92, 802-807.
55.
McDonagh, J.E., & Kelly, D.A. ( 2003). Transitioning care of the pediatric recipient to adult caregivers. Pediatr Clin North Am, 50(6), 1561-1583, xi-xii.
56.
McDonagh, J.E., & Viner, R.M. ( 2006). Lost in transition? Between paediatric and adult services . British Medical Journal, 332, 435-436.
57.
McGirt, M.J., Chaichana, K.L., Atiba, A., Attenello, F., Yao, K.C., & Jallo, G.I. ( 2008). Resection of intramedullary spinal cord tumors in children: Assessment of long-term motor and sensory deficits. Journal of Neurosurgery: Pediatrics, 1, 63-67.
58.
McPherson, M., Arango, P., Fox, H., Lauver, C., McManus, M., Newacheck, P.W., et al. (1998). A new definition of children with special health care needs. Pediatrics, 102(1, Pt. 1), 137-140.
59.
Meinardi, M.T., Gietema, J.A., van der Graaf, W.T., van Veldhuisen, D.J., Runne, M.A., Sluiter, W.J., et al. (2000). Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. Journal of Clinical Oncology , 18, 1725-1732.
60.
Merchant, T.E., Gould, C.J., Xiong, X., Robbins, N., Zhu, J., Pritchard, D.L., et al. (2004). Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors. International Journal of Radiation Oncology Biology Physics, 58, 1194-1207.
61.
Mitby, P.A., Robison, L.L., Whitton, J.A., Zevon, M.A., Gibbs, I.C., Tersak, J.M., et al. (2003). Utilization of special education services and educational attainment among long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer , 97, 1115-1126.
62.
Mulhern, R.K., Merchant, T.E., Gajjar, A., Reddick, W.E., & Kun, L.E. ( 2004). Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncology, 5, 399-408.
63.
Mulhern, R.K., Palmer, S.L., Merchant, T.E., Wallace, D., Kocak, M., Brouwers, P., et al. (2005). Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. Journal of Clinical Oncology, 23, 5511-5519.
64.
Nandagopal, R., Laverdiere, C., Mulrooney, D., Hudson, M.M., & Meacham, L. ( 2008). Endocrine late effects of childhood cancer therapy: A report from the Children’s Oncology Group. Hormone Research , 69, 65-74.
65.
Nathan, P.C., Patel, S.K., Dilley, K., Goldsby, R., Harvey, J., Jacobsen, C., et al. (2007). Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: A report from the Children’s Oncology Group. Archives of Pediatrics & Adolescent Medicine, 161, 798-806.
66.
Neglia, J.P., Robison, L.L., Stovall, M., Liu, Y., Packer, R.J., Hammond, S., et al. (2006). New primary neoplasms of the central nervous system in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Journal of the National Cancer Institute, 98, 1528-1537.
67.
Ness, K.K., Gurney, J.G., Zeltzer, L.K., Leisenring, W., Mulrooney, D.A., Nathan, P.C., et al. (2008). The impact of limitations in physical, executive, and emotional function on health-related quality of life among adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Archives of Physical Medicine and Rehabilitation, 89, 128-136.
68.
Newacheck, P.W. ( 2007). Insurance matters: Adolescents with special healthcare needs. Journal of Adolescent Health, 41, 319-320.
69.
Oberfield, S.E., & Sklar, C.A. ( 2002). Endocrine sequelae in survivors of childhood cancer . Adolescent Medicine, 13, 161-169.
70.
Oeffinger, K.C., & Eshelman, D.A. (2005). Transition issues. In C. L. Schwartz, W. L. Hobbie, L. S. Constine, & K. S. Ruccione (Eds.), Survivors of childhood and adolescent cancer: A multidisciplinary approach (pp. 333-344). Heidelberg, Germany: Springer.
71.
Oeffinger, K.C., & McCabe, M.S. (2006). Models for delivering survivorship care. Journal of Clinical Oncology, 24, 5117-5124.
72.
Oeffinger, K.C., Mertens, A.C., Sklar, C.A., Kawashima, T., Hudson, M.M., Meadows, A.T., et al. (2006). Chronic health conditions in adult survivors of childhood cancer. New England Journal of Medicine, 355, 1572-1582.
73.
Oeffinger, K.C., Nathan, P.C., & Kremer, L.C. ( 2008). Challenges after curative treatment for childhood cancer and long-term follow up of survivors. Pediatric Clinics of North America, 55, 251-273.
74.
Okumura, M.J., McPheeters, M.L., & Davis, M.M. ( 2007). State and national estimates of insurance coverage and health care utilization for adolescents with chronic conditions from the National Survey of Children’s Health, 2003. Journal of Adolescent Health, 41, 343-349.
75.
Olsen, J.H., Garwicz, S., Hertz, H., Jonmundsson, G., Langmark, F., Lanning, M., et al. (1993). Second malignant neoplasms after cancer in childhood or adolescence. Nordic Society of Paediatric Haematology and Oncology Association of the Nordic Cancer Registries. British Medical Journal, 307, 1030-1036.
76.
Palmer, S.L., Reddick, W.E., & Gajjar, A. ( 2007). Understanding the cognitive impact on children who are treated for medulloblastoma. Journal of Pediatric Psychology , 32, 1040-1049.
77.
Pang, J.W., Friedman, D.L., Whitton, J.A., Stovall, M., Mertens, A.C., Robison, L.L., et al. (2008). Employment status among adult survivors in the Childhood Cancer Survivor Study. Pediatric Blood Cancer , 50, 104-110.
78.
Partap, S., & Fisher, P.G. ( 2007). Update on new treatments and developments in childhood brain tumors. Current Opinion in Pediatrics, 19, 670-674.
79.
Raghavan, D., Cox, K., Childs, A., Grygiel, J., & Sullivan, D. ( 1992). Hypercholesterolemia after chemotherapy for testis cancer . Journal of Clinical Oncology, 10, 1386-1389.
80.
Reiss, J.G., Gibson, R.W., & Walker, L.R. ( 2005). Health care transition: Youth, family, and provider perspectives . Pediatrics, 115, 112-120.
81.
Reulen, R.C., Winter, D.L., Lancashire, E.R., Zeegers, M.P., Jenney, M.E., Walters, S.J., et al. (2007). Health status of adult survivors of childhood cancer: A large-scale population-based study from the British Childhood Cancer Survivor Study. International Journal of Cancer, 121, 633-640.
82.
Ries, L.A.G., Eisner, M.P., Kosary, C.L., Hankey, B.F., Miller, B.A., Clegg, L., et al. (2004). SEER cancer statistics review, 1975-2001 . Bethesda, MD: National Cancer Institute.
83.
Ris, M.D. ( 2007). Lessons in pediatric neuropsycho-oncology: What we have learned since Johnny Gunther. Journal of Pediatric Psychology , 32, 1029-1037.
84.
Robertson, L. ( 2006). When should young people with chronic rheumatic disease move from pediatric to adult-centred care? Best Pract Res Clin Rheumatol, 20(2), 387-397.
85.
Robertson P.L., Muraszko K.M., Holmes E.J., et al. (2006). Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children’s Oncology Group. J Neurosurg (6 Suppl Pediatrics) 105: 444-451.
86.
Romestaing, P., & Hullo, A. ( 1997). Late effects of radiation on the eye and ocular adnexa . Cancer Radiotherapy, 1, 683-691.
87.
Rosen, D.S. ( 1993). Transition to adult health care for adolescents and young adults with cancer. Cancer, 71(Suppl. 10), 3411-3414.
88.
Rosen, D.S. ( 1994). Transition from pediatric to adult-oriented health care for the adolescent with chronic illness or disability. Adolescent Medicine, 5, 241-248.
89.
Rutter, M.M., & Rose, S.R. ( 2007). Long-term endocrine sequelae of childhood cancer . Current Opinion in Pediatrics, 19, 480-487.
90.
Sawyer, S.M., Blair, S., & Bowes, G. ( 1997). Chronic illness in adolescents: Transfer or transition to adult services? Journal of Paediatric Child Health, 33, 88-90.
91.
Scal, P. ( 2002). Transition for youth with chronic conditions: Primary care physicians’ approaches. Pediatrics, 110(6, Pt. 2), 1315-1321.
92.
Scal, P., & Ireland, M. ( 2005). Addressing transition to adult health care for adolescents with special health care needs. Pediatrics, 115, 1607-1612.
93.
Schidlow, D.V., & Fiel, S.B. ( 1990). Life beyond pediatrics: Transition of chronically ill adolescents from pediatric to adult health care systems. Medical Clinics of North America, 74, 1113-1120.
94.
Schmiegelow, M., Lassen, S., Poulsen, H.S., Schmiegelow, K., Hertz, H., Andersson, A.M., et al. (2001). Gonadal status in male survivors following childhood brain tumors. Journal of Clinical Endocrinology & Metabolism, 86, 2446-2452.
95.
Schultz, K.A., Ness, K.K., Whitton, J., Recklitis, C., Zebrack, B., Robison, L.L., et al. (2007). Behavioral and social outcomes in adolescent survivors of childhood cancer: A report from the childhood cancer survivor study. Journal of Clinical Oncology, 25, 3649-3656.
96.
Skinner, R., Wallace, W.H., & Levitt, G.A. ( 2006). Long-term follow-up of people who have survived cancer during childhood. Lancet Oncology, 7, 489-498.
97.
Skinner, R., Wallace, W.H., & Levitt, G.A. ( 2007). Long-term follow-up of children treated for cancer: Why is it necessary, by whom, where and how?Archives of Disease in Childhood, 92, 257-260.
98.
Sklar, C.A. ( 1997). Growth and neuroendocrine dysfunction following therapy for childhood cancer. Pediatric Clinics of North America , 44, 489-503.
Sonderkaer, S., Schmiegelow, M., Carstensen, H., Nielsen, L.B., Muller, J., & Schmiegelow, K. (2003). Long-term neurological outcome of childhood brain tumors treated by surgery only. Journal of Clinical Oncology, 21, 1347-1351.
101.
Talvensaari, K., & Knip, M. ( 1997). Childhood cancer and later development of the metabolic syndrome. Annals of Medicine, 29, 353-355.
102.
Talvensaari, K.K., Lanning, M., Tapanainen, P., & Knip, M. ( 1996). Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. Journal of Clinical Endocrinology Metabolism, 81, 3051-3055.
103.
Tong, E.M., & Kools, S. ( 2004). Health care transitions for adolescents with congenital heart disease: Patient and family perspectives. Nursing Clinics of North America, 39, 727-740.
104.
Tsamasiros, J., & Bartsocas, C.S. (2002). Transition of the adolescent from the children’s to the adults’ diabetes clinic. Journal of Pediatric Endocrinology & Metabolism, 15, 363-367.
105.
Valk, G.D., Renders, C.M., Kriegsman, D.M., Newton, K.M., Twisk, J.W., van Eijk, J.T., et al. (2004). Quality of care for patients with type 2 diabetes mellitus in the Netherlands and the United States: a comparison of two quality improvement programs. Health Serv Res, 39(4 Pt 1), 709-725.
106.
Vinchon, M., & Dhellemmes, P. (2007). The transition from child to adult in neurosurgery. Advances and Technical Standards in Neurosurgery, 32, 3-24.
107.
Viner, R. ( 2003). Bridging the gaps: Transition for young people with cancer . European Journal of Cancer, 39, 2684-2687.
108.
Wallace, W.H., Blacklay, A., Eiser, C., Davies, H., Hawkins, M., Levitt, G.A., et al. (2001). Developing strategies for long-term follow-up of survivors of childhood cancer. British Medical Journal , 323, 271-274.
109.
White, P.H. ( 2002). Access to health care: Health insurance considerations for young adults with special health care needs/disabilities. Pediatrics, 110(6, Pt. 2), 1328-1335.
110.
Wilson V., McDonough J., Tochner Z. ( 2005). J Pediatr Hematol Oncol. 27: 444-448.
111.
Yeazel, M.W., Gurney, J.G., Oeffinger, K.C., Mitby, P.A., Mertens, A.C., Hudson, M.M., et al. (2004). An examination of the dental utilization practices of adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Journal of Public Health Dentistry , 64, 50-54.
112.
Zebrack, B.J., Eshelman, D.A., Hudson, M.M., Mertens, A.C., Cotter, K.L., Foster, B.M., et al. (2004). Health care for childhood cancer survivors: Insights and perspectives from a Delphi panel of young adult survivors of childhood cancer. Cancer, 100, 843-850.
113.
Zebrack, B.J., Gurney, J.G., Oeffinger, K., Whitton, J., Packer, R.J., Mertens, A., et al. (2004). Psychological outcomes in long-term survivors of childhood brain cancer: A report from the childhood cancer survivor study . Journal of Clinical Oncology, 22, 999-1006.
114.
Zeltzer, L.K., Lu, Q., Leisenring, W., Tsao, J.C., Recklitis, C., Armstrong, G., et al. (2008). Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: A report from the childhood cancer survivor study. Cancer Epidemiology Biomarkers & Prevention, 17, 435-446.
