This integrative literature review focuses on (1) the spectrum of cardiovascular late effects; (2) the factors that can influence the development of cardiovascular late effects; and (3) the role of the pediatric oncology nurse in minimizing the risks of cardiovascular late effects and associated disabilities in childhood cancer survivorship. The results showed that survivors who have been treated with radiation therapy, especially when the field includes the heart or the hypothalamic-pituitary axis (HPA), and specific chemotherapies are at increased risk for developing particular cardiovascular risk factors and/or cardiovascular disease. Younger age at diagnosis, longer time since treatment, and family history of early heart disease can further heighten the risks. The role of pediatric oncology nurses in the promotion of cardiovascular health for children with cancer across the illness trajectory is discussed.
Adams, M., Hardenbergh, P., Constine, L., & Lipshultz, S. (2003). Radiation-associated cardiovascular disease. Critical Reviews in Oncology Hematology, 45, 55-75.
2.
Adams, M., Lipsitz, S., Colan, S., Tarbell, N., Treves, T., Diller, L., et al. (2004). Cardiovascular status in long-term survivors of Hodgkin’s disease treated with chest radiotherapy. Journal of Clinical Oncology, 22, 3139-3148.
3.
Amato, G., Carella, C., Fazio, S., La Montagne, G., Cittadini, A., Sabatini, D., et al. (1993). Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. Journal of Clinical Endocrinology & Metabolism, 77, 1671-1676.
4.
American Cancer Society. (2004). Cancer facts and figures 2004. Retrieved September 22, 2004, from http://www.cancer.org/downloads/STT/CAFF_finalPNSecured.pdf
5.
American Heart Association. (2004). Heart disease and stroke statistics–2004 update, American Heart Association. Retrieved April 19, 2004, from http://www.americanheart.org/downloadable/heart/1079736729696HDSStats2004
6.
Barlow, S., & Dietz, W. (1998). Obesity evaluation and treatment: Expert committee recommendations. Pediatrics, 102, 29-48.
7.
Berenson, G., Srinivasan, S., Bao, W., Newman, W., Tracy, R., & Wattigney, W. (1998). Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. New England Journal of Medicine, 338, 1650-1656.
8.
Birkebaek, N., & Clausen, N. (1998). Height and weight pattern up to 20 years after treatment for acute lymphoblastic leukemia. Archives of Disease in Childhood, 79, 161-164.
9.
Birkebaek, N., Fisker, S., Clausen, N., Tuovinen, V., Sindet-Pedersen, S., & Christiansen, J. (1998). Growth and endocrinological disorders up to 21 years after treatment for acute lymphoblastic leukemia in children. Medical & Pediatric Oncology, 30, 351-356.
10.
Braunwald, E. (2001). Heart disease: A textbook of cardiovascular medicine (6th ed.). Philadelphia, PA: W. B. Saunders.
11.
Brennan, B., Rahim, A., Blum, W., Adams, J., Eden, O., & Shalet, S. (1999). Hyperleptinaemia in young adults following cranial irradiation in childhood: Growth hormone deficiency or leptin insensitivity?Clinical Endocrinology, 50, 163-169.
12.
Brennan, B., Rahim, A., Mackie, E., Eden, O., & Shalet, S. (1998). Growth hormone status in adults treated for acute lymphoblastic leukemia in childhood. Clinical Endocrinology, 48, 777-783.
13.
Brown, W., Sibille, K., Phelps, L., & McFarlane, K. (2002). Obesity in children and adolescents. Clinics in Family Practice, 4, 603-611.
14.
Darzy, K., Aimaretti, G., Wieringa, G., Rao Gattamaneni, H., Ghigo, E., & Shalet, S. (2003). The usefulness of combined growth hormone-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced growth hormone deficiency is dependent on the post-irradiation time interval. Journal of Clinical Endocrinology & Metabolism, 88, 95-102.
15.
Dixon, J. K., & Dixon, J. P. (2002). An integrative model for environmental health research. Advances in Nursing Science, 24, 43-57.
16.
Eames, G., Crosson, J., Steinberger, J., Steinbuch, M., Krabill, K., Bass, J., et al. (1997). Cardiovascular function in children following bone marrow transplant: A cross-sectional study. Bone Marrow Transplant, 19, 61-66.
17.
Erickson, J. (2004). Fatigue in adolescents with cancer: A review of the literature. Clinical Journal of Oncology Nursing, 8, 139-145.
18.
Friedman, D., Dietz, W., Srinivasan, S., & Berenson, G. (1999). The relation of overweight to cardiovascular risk factors among children and adolescents: The Bogalusa Heart Study. Pediatrics, 103, 1175-1182.
19.
Friedman, D., & Meadows, A. (2002). Late effects of childhood cancer therapy. Pediatric Clinics of North America, 49, 1083-1106.
20.
Ganong, L. (1987). Integrative reviews of nursing research. Research in Nursing & Health, 10, 1-11.
21.
Garrard, J. (1999). Health sciences literature review made easy: The matrix method. Gaithersburg, MD: Aspen.
22.
Glanzmann, C., Kaufmann, P., Jenni, R., Hess, O. M., & Huguenin, P. (1998). Cardiac risk after mediastinal irradiation for Hodgkin’s disease. Radiotherapy and Oncology, 46, 51-62.
23.
Groot-Loonen, J., Otten, B., van’t Hof, M., Lippens, R., & Stoelinga, G. (1996). Influence of treatment modalities on body weight in acute lymphoblastic leukemia. Medical & Pediatric Oncology, 27, 92-97.
24.
Gurney, J., Kadan-Lottick, N., Packer, R., Neglia, J., Sklar, C., Punyko, J., et al. (2003). Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors. Cancer, 87, 663-673.
25.
Gurney, J., Ness, K., Stovall, M., Wolden, S., Punyko, J., Neglia, J., et al. (2003). Final height and body mass index among adult survivors of childhood brain cancer: Childhood Cancer Survivor Study. Journal of Clinical Endocrinology & Metabolism, 88, 4731-4739.
26.
Harrell, J., Pearce, P., & Hayman, L. (2003). Fostering prevention in the pediatric population. Journal of Cardiovascular Nursing, 18, 144-149.
27.
Heikens, J., Ubbink, M., van der Pal, H., Bakker, P., Fliers, E., Smilde, T., et al. (2000). Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. Cancer, 88, 2116-2121.
28.
Hinkle, A., Proukou, C., French, C., Kozlowski, A., Constine, L., Lipsitz, S., et al. (2004). A clinic-based, comprehensive care model for studying late effects in long-term survivors of pediatric illnesses. Pediatrics, 113, 1141-1145.
29.
Hogarty, A., Leahey, A., Zhao, H., Hogarty, M., Bunin, N., Cnaan, A., et al. (2000). Longitudinal evaluation of cardiopulmonary performance during exercise after bone marrow transplantation in children. Journal of Pediatrics, 136, 311-317.
30.
Howard, S., & Pui, C. (2002). Endocrine complications in pediatric patients with acute lymphoblastic leukemia. Blood Reviews, 16, 225-243.
31.
Hudson, M., Landier, W., Eshelman, D., Forte, K., Darling, J., Hester, A., et al., for the Late Effects Committee, Children’s Oncology Group. (2004). Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers (version 1.2). Available online at http:www.childrensoncologygroup.org/disc/LE/default.htm
32.
Krebs, N., Baker, R., Greer, F., Heyman, M., Jaksic, T., Lifshitz, F., et al., for the Committee on Nutrition, American Academy of Pediatrics. (2003). Prevention of pediatric overweight and obesity. Pediatrics, 112, 424-430.
33.
Langeveld, N., Ubbink, M., & Smets, E. (2000). “I don’t have any energy”: The experience of fatigue in young adult survivors of childhood cancer. European Journal of Oncology Nursing, 4, 20-28.
34.
Larsen, P. (2003). Endocrine disorders. In Williams textbook of endocrinology (10th ed., pp. 1050-1092). Philadelphia, PA: W. B. Saunders.
35.
Lustig, R., Post, S., Srivannaboon, K., Rose, S., Danish, R., Burghen, G., et al. (2003). Risk factors for the development of obesity in children surviving brain tumors. Journal of Clinical Endocrinology & Metabolism, 88, 611-616.
36.
Nysom, K., Holm, K., Lipsitz, S., Mone, S., Colan, S., Orav, E., et al. (1998). Relationship between cumulative anthracycline dose and late cardiotoxicity in childhood acute lymphoblastic leukemia. Journal of Clinical Oncology, 16, 545-550.
37.
Nysom, K., Holm, K., Michaelsen, K., Hertz, H., Muller, J., & Molgaard, C. (1999). Degree of fatness after treatment for acute lymphoblastic leukemia in childhood. Journal of Clinical Endocrinology & Metabolism, 84, 4591-4596.
38.
Oeffinger, K. (2000). Grading of late effects in young adult survivors of childhood cancer followed in an ambulatory adult setting. Cancer, 88, 1687-1695.
39.
Oeffinger, K., Buchanan, G., Eshelman, D., Denke, M., Andrews, T., Germak, J., et al. (2001). Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology, 23, 424-430.
40.
Oeffinger, K., & Hudson, M. (2004). Long-term complications following childhood and adolescent cancer: Foundations for providing risk-based health care for survivors. CA: A Journal for Clinicians, 54, 208-236.
41.
Oeffinger, K., Mertens, A., Sklar, C., Yasui, Y., Fears, T., Stovall, M., et al. (2003). Obesity in adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology, 21, 1359-1365.
42.
Pathobiological Determinants of Atherosclerosis in Youth Research Group. (1993). Natural history of aortic and coronary atherosclerotic lesions in youth: Findings from the PDAY study. Arteriosclerosis & Thrombosis, 13, 1291-1298.
43.
Poutanen, T., Tikanoja, T., Riikonen, P., Silvast, A., & Perkkio, M. (2003). Long-term prospective follow-up study of cardiac function after cardiotoxic therapy for malignancy in children. Journal of Clinical Oncology, 21, 2349-2356.
44.
Sklar, C., Mertens, A., Walter, A., Mitchell, D., Nesbit, M., O’Leary, M., et al. (2000). Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: Role of cranial irradiation. Medical & Pediatric Oncology, 35, 91-95.
45.
Steinherz, L., & Yahalom, J. (2000). Cardiac toxicity. Retrieved May 16, 2002, from http://pco.ovid.com/Irpbooks/cppo/textbook/chapters/ch0055_004htm
46.
Talvensaari, K., & Knip, M. (1997). Childhood cancer and later development of the metabolic syndrome. Annals of Medicine, 29, 353-355.
47.
Talvensaari, K., Lanning, M., Tapanainen, P., & Knip, M. (1996). Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. Journal of Clinical Endocrinology & Metabolism, 81, 3051-3055.
48.
Warner, J., Bell, W., Webb, D., & Gregory, J. (1997). Relationship between cardiopulmonary response to exercise and adiposity in survivors of childhood malignancy. Archives of Disease in Childhood, 76, 298-303.
49.
Warner, J., Evans, W., Webb, D., & Gregory, J. (2002). Body composition of long-term survivors of acute lymphoblastic leukemia. Medical & Pediatric Oncology, 38, 165-172.
50.
Wynne, A., Woo, T., & Millard, M. (Eds.). (2002). Pharmacotherapeutics for nurse practitioner prescribers. Philadelphia, PA: F. A. Davis.
