Research on individual and family responses to a child’s or adolescent’s cancer diagnosis and treatment is important because of significant advances in the field of pediatric oncology. To date, the majority of research has been behavioral or psychosocial in nature. It could be argued that a more holistic perspective that includes psychological, sociocultural, and biological dimensions would advance knowledge about individual and family responses to the experience of childhood cancer. Biobehavioral research refers to investigations that link behavioral and biological underpinnings in specific areas of science. The purpose of this article is to review research in two broad areas that could benefit from a biobehavioral perspective—psychosocial functioning/behavioral adjustment, and CNS treatment outcomes. Studies that include biological measures are highlighted. Advantages, challenges, and strategies for advancing biobehavioral research in childhood cancer are proposed.
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References
1.
Boman, K., Lindahl, A., & Bjork, O. (2003). Disease-related distress in parents of children with cancer at various stages after the time of diagnosis. Acta Oncologica, 42, 137-146.
2.
Cavusoglu, H. (2001). Depression in children with cancer. Journal of Pediatric Nursing, 16, 380-385.
3.
Cowan, M. J., Heinrich, J., Lucas, M., Sigmon, H., & Hinshaw, A. S. (1993). Integration of biological and nursing sciences: A 10-year plan to enhance research and training. Research in Nursing and Health, 16, 3-9.
4.
Espy, K. A., Moore, I. M., Kaufmann, P. H., Kramer, J. H., Matthey, K., & Hutter, J. J. (2001). Chemotherapeutic CNS prophylaxis and neuropsychologic change in children with acute lymphoblastic leukemia: A prospective study. Journal of Pediatric Psychology, 26, 1-9.
5.
Glover, D. A., & Poland, R. E. (2002). Urinary cortisol and catecholamines in mothers of child cancer survivors with and without PTSD. Psychoneuroendocrinology, 27, 805-819.
6.
Korinthenberg, R., Schneider, A., & Niemeyer, C. (2002). Central nervous system prophylaxis with high-dose methotrexate does not give rise to significant electroencephalographic changes in children with acute lymphoblastic leukemia. Journal of Child Neurology, 17, 409-412.
7.
Kupst, M. J., Penati, B., Debban, B., Camitta, B., Pietryga, D., Margolis, D., et al. (2002). Cognitive and psychosocial functioning of pediatric hematopoietic stem cell transplant patients: A prospective longitudinal study. Bone Marrow Transplantation, 30, 609-617.
8.
Langer, T., Martus, P., Ottensmeier, H., Hertzberg, H., Beck, J. D., Meier, W. (2002). CNS late-effects after ALL therapy in childhood. Part III: Neuropsychological performance in long-term survivors of childhood ALL: Impairments of concentration, attention, and memory. Medical Pediatric Oncology, 38, 320-328.
9.
Meeske, K. A., Ruccione, K., Globe, D. R., & Stuber, M. L. (2001). Posttraumatic stress, quality of life, and psychological distress in young adult survivors of childhood cancer. Oncology Nursing Forum, 28, 481-489.
10.
Moore, I. M., Challinor, J., Pasvogel, A., Matthay, K., Hutter, J., & Kaemingk, K. (2003). Behavioral adjustment of children and adolescents with cancer: Teacher, parent, and self-report. Oncology Nursing Forum, 30, 1-15.
11.
Moore, I. M., Espy, K. A., Kaufmann, P. H., Kramer, J. H., Kaeningk, K., Miketova, P., et al. (2000). Cognitive consequences and central nervous system injury following treatment for childhood leukemia. Seminars in Oncology Nursing, 16, 279-290.
12.
Murray, J. S. (2001). Social support for school-aged siblings of children with cancer: A comparison between parent and sibling perceptions. Journal of Pediatric Oncology Nursing, 18, 90-104.
13.
Reddick, W. E., White, H. A., Glass, J. O., Wheeler, G. C., Thompson, S. J., Gajjaar, A., et al. (2003). Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer, 97, 2512-2519.
14.
Reimers, T. S., Ehrenfels, S., Mortensen, E. L., Schmiegelow, M., Sonderkaer, S., Castensen, H., et al. (2003). Cognitive deficits in long-term survivors of childhood brain tumors: Identification of predictive factors. Medical and Pediatric Oncology, 40, 26-34, 2003.
15.
Reiter-Purtill, J., Vannatta, K., Gerhardt, C. A., Correll, J., & Noll, R. B. (2003). A controlled longitudinal study of the social functioning of children who completed treatment of cancer. Journal of Pediatric Hematology/Oncology, 25, 467-473.
16.
Santacroce, S. (2002). Uncertainty, anxiety, and symptoms of posttraumatic stress in parents of children recently diagnosed with cancer. Journal of Pediatric Oncology Nursing, 19, 104-111.
17.
Trask, P. C., Paterson, A. G., Trask, C. L., Bares, C. B., Birt, J., & Maan, C. (2003). Parent and adolescent adjustment to pediatric cancer: Associations with coping, social support, and family function. Journal of Pediatric Oncology Nursing, 20, 36-47.
18.
Von der Weid, N., Mosimann, I., Hirt, A., Wacker, P., Nenadov, B. M., Imbach P., et al. (2003). Intellectual outcome in children and adolescents with acute lymphoblastic leukemia treated with chemotherapy alone: Age-and sex-related differences. European Journal of Cancer, 39, 359-365.
19.
Wynne, N., Brand, S., & Smith, R. (1997). Incomplete holism in pre-registration nurse education: The position of the biological sciences. Journal of Advanced Nursing, 26, 470-474.
20.
Yeh, C. (2002). Gender differences of parental distress in children with cancer. Journal of Advanced Nursing, 38, 698-606.
21.
Zebrack, B. J., Aeltzer, L. K., Whitton, J., Mertens, A. C., Odom, L., Berkow, R., et al. (2002). Psychological outcomes in longterm survivors of childhood leukemia, Hodgkin’s disease, and non-Hodgkin’s lymphoma: A report from the Childhood Cancer Care Survivor Study. Pediatrics, 110, 42-52.
