A review of the clinical research studies published within the past 5 years revealed that efforts to manage symptoms of cancer and its treatments have not kept pace with new advances in the cure for cancer. Children with cancer continue to experience distressing physical symptoms caused by the disease and treatment. The purpose of this article is to provide a concise overview of the most common symptoms experienced by children with cancer. These symptoms include pain, nausea and vomiting, nutritional concerns, mucositis, and fatigue experienced by the child with cancer. Recommendations for future research are addressed.
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References
1.
Aksoylar, S., Akman, S. A., Ozgenc, F., & Kansoy, S. (2001). Comparison of tropisetron and granisetron in the control of nausea and vomiting in children receiving combined cancer chemotherapy . Pediatric Hematology and Oncology, 18(6), 397-406 .
2.
Bonnaure-Mallet, M., Bunetel, L., Tricott-Loleux, S., Guerin, J., Bergeron, C., & LeGall, E. (1998). Oral complications during treatment of malignant diseases in childhood: Effects of tooth brushing . European Journal of Cancer, 34(10), 1588-1591 .
3.
Broome, M. E., Rehwaldt, M., & Fogg, L. (1998). Relationship between cognitive behavioral techniques, temperament, observed distress, and pain reports in children an adolescents during lumbar puncture . Journal of Pediatric Nursing, 13(1), 48-54 .
4.
Chen, E., Craske, M. G., Katz, E. R., Schwartz, E., & Zeltzer, L. K. (2000). Pain-sensitive temperament: Does it predict procedural distress and response to psychological treatment among children with cancer? Journal of Pediatric Psychology, 25(4), 269-278 .
5.
Cheng, K. K., Molassiotis, A., & Chang, A. M. (2002). An oral care protocol intervention to prevent chemotherapy-induced oral mucositis in paediatric cancer patients: A pilot study . European Journal of Oncological Nursing, 6(2), 66-73 .
6.
Cheng, K. K., Molassiotis, A., Chang, A. M., Wai, W. C., & Cheung, S. S. (2001). Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients . European Journal of Cancer, 37(16), 2056-2063 .
7.
Collins, J. J., Byrnes, M. E., Dunkel, I. J., Lapin, J., Nadel, T., Thaler, H. T., et al. (2000). The measurement of symptoms in children with cancer . Journal of Pain and Symptom Management, 19(5), 363-373 .
8.
Collins, J. J., Dunkel, I. J., Gupta, S. K., Inturrisi, C. E., Lapin, J., Palmer, L. N., et al. (1999). Transdermal fentanyl in children with cancer pain: Feasibility, tolerability, and pharmacokinetic correlates . Journal of Pediatrics, 134(3), 319-323 .
9.
Crock, C., Olsson, C., Phillips, R., Chalkiadis, G., Sawyer, S., Ashley, D., et al. (2003). General anaesthesia or conscious sedation for painful procedures in childhood cancer: The family’s perspective . Archives of Disease in Childhood, 88(3), 253-257 .
10.
Davies, B., Whitsett, S. F., Bruce, A., & McCarthy, P. (2002). A typology of fatigue in children with cancer . Journal of Pediatric Oncology Nursing, 19(1), 12-21 .
11.
DeSwarte-Wallace, J., Firouzbakhsh, S., & Finklestein, J. Z. (2001). Using research to change practice: Enteral feedings for pediatric oncology patients . Journal of Pediatric Oncology Nursing, 18(5), 217-223 .
12.
Docherty, S. L. (2003). Symptom experiences of children and adolescents with cancer . Annual Review of Nursing Research, 21, 123-149 .
13.
Eksborg, S., Pal, N., Kalin, M., Palm, C., & Soderhall, S. (2002). Pharmacokinetics of acyclovir in immunocompromised children with leukopenia and mucositis after chemotherapy: Can intravenous acyclovir be substituted by oral valacyclovir? Medical and Pediatric Oncology, 38(4), 240-246 .
14.
Favara-Scacco, C., Smirne, G., Schiliro, G., & Di Cataldo, A. (2001). Art therapy as support for children with leukemia during painful procedures . Medical and Pediatric Oncology, 36(4), 474-480 .
15.
Hain, R. D., & Campbell, C. (2001). Invasive procedures carried out in conscious children: Contrast between North American and European paediatric oncology centres . Archives of Disease in Childhood, 85, 12-15 .
16.
Hedstrom, M., Haglund, K., Skolin, I., & von Essen, L. (2003). Distressing events for children and adolescents with cancer: Child, parent, and nurse perceptions . Journal of Pediatric Oncology Nursing, 20(3), 120-132 .
17.
Hellsten, M. B. (2000). All the king’s horses and all the king’s men: Pain management from hospital to home . Journal of Pediatric Oncology Nursing, 17(3), 149-159 .
18.
Hinds, P. S., Hockenberry-Eaton, M., Quargnenti, A., May, M., Burleson, C., Gilger, E., et al. (1999). Fatigue in 7to 12-year-old patients with cancer from the staff perspective: An exploratory study . Oncology Nursing Forum, 26(1), 37-45 .
19.
Hockenberry, M. J., Hinds, P. S., Barrera, P., Bryant, R., Adams-McNeill, J., Hooke, C., et al. (2003). Three instruments to assess fatigue in children with cancer: The child, parent and staff perspectives . Journal of Pain and Symptom Management, 25(4), 319-328 .
20.
Hockenberry-Eaton, M., Hinds, P. S., Alcoser, P., O’Neill, J. B., Euell, K., Howard, V., et al. (1998). Fatigue in children and adolescents with cancer . Journal of Pediatric Oncology Nursing, 15(3), 172-182 .
21.
Hunt, A., Joel, S., Dick, G., & Goldman, A. (1999). Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustainedrelease tablets for cancer pain . Journal of Pediatrics, 135(1), 47-55 .
22.
Jayabose, S., Levendoglu-Tugal, O., Giamelli, J., Grodin, W., Cohn, M., Sandoval, C., et al. (2001). Intravenous anesthesia with propofol for painful procedures in children with cancer . Journal of Pediatric Hematology/Oncology, 23(5), 290-293 .
23.
Langdana, A., Tully, N., Molloy, E., Bourke, B., & O’Meara, A. (2001). Intensive enteral nutrition support in paediatric bone marrow transplantation . Bone Marrow Transplantation, 27(7), 741-746 .
24.
Levy-Polack, M. P., Sebelli, P., & Polack, N. L. (1998). Incidence of oral complications and application of a preventive protocol in children with acute leukemia . Special Care Dentist, 18(5), 189-193 .
25.
Ljungman, G., Gordth, T., Sorensen, S., & Kreuger, A. (2001). Lumbar puncture in pediatric oncology: Conscious sedation vs. general anesthesia . Medical and Pediatric Oncology, 36(3), 372-379 .
26.
Lo, L. H., & Hayman, L. L. (1999). Parents associated with children in measuring acute and delayed nausea and vomiting . Nursing Health Science, 1, 155-161 .
27.
McCarthy, A. M., Cool, V. A., & Hanrahan, K. (1998). Cognitive behavioral interventions for children during painful procedures: Research challenges and program development . Journal of Pediatric Nursing, 13(1), 55-63 .
28.
Muscaritoli, M., Grieco, G., Capria, S., Iori, A. P., & Rossi, F. (2002). Nutritional and metabolic support in patients undergoing bone marrow transplantation . American Journal of Clinical Nutrition, 75(2), 183-190 .
29.
Oberbaum, M., Yaniv, I., Ben-Gal, Y., Stein, J., Ben-Zvi, N., Freedman, L. S., et al. (2001). A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation . Cancer, 92(3), 684-690 .
30.
Ozkan, A., Yildiz, I., Yuksel, L., Apak, H., & Celkan, T. (1999). Tropisetron (Navoban) in the control of nausea and vomiting induced by combined cancer chemotherapy in children . Japanese Journal of Clinical Oncology, 29(2), 92-95 .
31.
Pellier, I., Monrigal, J. P., LeMoine, P., Rod, B., Rialland, X., & Ganry, J. C. (1999). Use of intravenous ketamine-midazolam association for pain procedures in children with cancer. A prospective study . Paediatric Anaesthesia, 9(1), 61-68 .
32.
Pietsch, J. B., Ford, C., & Whitlock, J. A. (1999). Nasogastric tube feedings in children with high-risk cancer: A pilot study . Journal of Pediatric Hematology/Oncology, 21(2), 111-114 .
33.
Skolin, I., Ulla-Kaisa, K. H., & Wahlin, Y. B. (2001). Parents’ perception of their child’s food intake after the start of chemotherapy . Journal of Pediatric Oncology Nursing, 18(3), 124-136 .
34.
Stiakaki, E., Savvas, S., Lydaki, E., Bolonaki, I., Kouvidi, E., Dimitriou, H., et al. (1999). Ondansetron and tropisetron in the control of nausea and vomiting in children receiving combined cancer chemotherapy . Pediatric Hematology and Oncology, 16(2), 101-108 .
35.
Tyc, V. L., Bieberich, A. A., Hinds, P., & Sifford, L. (1998). A survey of pain services for pediatric oncology patients: Their composition and function . Journal of Pediatric Oncology Nursing, 15(4), 207-215 .
36.
Varni, J. W., Burwinkle, T. M., Katz, E. R., Meeske, K., & Dickinson, P. (2002). The Peds QL in pediatric cancer: Reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module . Cancer, 94(7), 2090-2106 .
37.
Williams, R., Virtue, K., & Adkins, A. (1998). Room service improves patient food intake and satisfaction with hospital food . Journal of Pediatric Oncology Nursing, 15(3), 183-189 .
38.
Woodgate, R. L., & Degner, L. F. (2003). Expectations and beliefs about children’s cancer symptoms: Perspective of children with and their families . Oncology Nursing Forum, 30(3), 479-491 .
