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Abstract

Stegelmeier, BL, et al.: 2010, Experimental rayless goldenrod (Isocoma pluriflora) toxicosis in goats. J Vet Diagn Invest. 22: 570–577

In the article “Experimental rayless goldenrod (Isocoma pluriflora) toxicosis in goats” by Bryan L. Stegelmeier et al., the published mean body weight and the means and statistics of serum biochemistries were carried out on groups of 4 animals, not 3, as described in the Material and Methods section. The additional animal in each group was part of an auxiliary physiologic study and though the animals were dosed and treated the same, they were not necropsied and were not included in the histologic study. To correct this oversight, the corrected weight and chemistry table (shaded cells indicate corrected numbers) are listed below. The differences are minimal and do not alter the conclusions. In addition, reference 7 has been deleted.

Material and Methods: “Fifteen, yearling, female Spanish goats weighing 29.4 ± 3.4 kg (mean ± standard deviation) were randomly divided into 5 groups with 3 animals per group.”

References: Reference 7 should be deleted

Corrected Table 1.

Selected mean serum biochemical data from groups of 3 goats dosed with rayless goldenrod (Isocoma pluriflora) to obtain benzofuran ketone doses of 0, 10, 20, 40, and 60 mg/kg body weight for 7 days.*

		Serum result (mean ± standard deviation)
Serum test (reference range†)	Dose	Day 0	Day 3	Day 6	Day 7
Creatinine kinase (< 350 U/l)	0	226 ± 93	107 ± 6	73 ± 16^a	66 ± 30^a
	10	226 ± 160	118 ± 8	206 ± 184^a	495 ± 623^ab
	20	967 ± 1233	306 ± 276	240 ± 113^a	497 ± 277^ab
	40	125 ± 18	117 ± 24	6,699 ± 5,329^b	16,270 ± 11,054^b
	60	202 ± 93	202 ± 124	2,987 ± 3,701^a	10,433 ± 4,326^ab
Cardiac troponin-I (<0.40 U/l‡)	0	<0.02 ± 0.0	<0.02 ± 0.0	<0.02 ± 0.0	<0.02 ± 0.0
	10	<0.02 ± 0.0	<0.02 ± 0.0	<0.02 ± 0.0	<0.02 ± 0.0
	20	<0.02 ± 0.0	0.17 ± 0.26	0.05 ± 0.03	<0.02 ± 0.0
	40	<0.02 ± 0.0	<0.02 ± 0.0	1.98 ± 3.39	1.79 ± 2.97
	60	<0.02 ± 0.0	<0.02 ± 0.0	1.38 ± 2.31	0.13 ± 0.18
Aspartate aminotransferase (<125 U/l)	0	96 ± 7	91 ± 6	83 ± 2^a	72 ± 3^a
	10	147 ± 69	104 ± 11	89 ± 8^a	97 ± 13^a
	20	164 ± 82	284 ± 248	293 ± 252^ab	376 ± 256^a
	40	112 ± 17	102 ± 12	991 ± 184^c	3,277 ± 1,556^b
	60	96 ± 13	115 ± 31	819 ± 571^bc	2,095 ± 1,333^b
Alanine aminotransferase (<55 U/l)	0	39 ± 3	37 ± 3	38 ± 0^a	43 ± 18^a
	10	44 ± 1	42 ± 3	39 ± 2^a	37 ± 1^a
	20	41 ± 9	57 ± 34	63 ± 38^ab	61 ± 25^a
	40	46 ± 2	44 ± 4	134 ± 24^a	333 ± 127^b
	60	40 ± 7	44 ± 5	118 ± 84^ab	267 ± 176^b
Lactate dehydrogenase (<1,560 U/l)	0	1,061 ± 145	1,075 ± 62	875 ± 213^a	573 ± 115^a
	10	1,334 ± 668	1,050 ± 223	942 ± 265^a	709 ± 182^a
	20	1,650 ± 1,546	2,617 ± 2,685	1,185 ± 449^a	753 ± 447^a
	40	1,054 ± 201	1,162 ± 130	5,996 ± 2,491^b	9,891 ± 3,210^b
	60	1,026 ± 287	1,277 ± 348	3,623 ± 2,924^ab	7,011 ± 5,205^a

Different means (<0.05) between groups are indicated with superscript letters.

†

Estimates of normal range were determined as 2 standard deviations from mean values of control goats and pretreatment samples. These ranges are probably laboratory and assay specific.

‡

Cardiac troponin-I concentrations below detection limits are reported as <0.02 ng/ml.

Corrigendum

Abstract

References: Reference 7 should be deleted