Three soft tissue tumors from 2 female hedgehogs were examined microscopically and immunohistochemically. Two tumors involved haired skin and the third one was vaginal. Microscopically, the cutaneous tumors had features of malignant peripheral nerve sheath tumor (MPNST), whereas the vaginal tumor was classified only as a spindle cell sarcoma. Immunohistochemically, all 3 tumors were strongly positive for vimentin and strongly to moderately positive for CD10 and neuron-specific enolase but did not stain with antibody to S100 protein, an antigen typically present in human MPNST. The cutaneous tumor from hedgehog no. 1 was examined ultrastructurally and the neoplastic cells resembled fibroblasts. Hedgehog no. 1 was euthanized at the time of the biopsy. The outcome of the other hedgehog was unknown.
References
1.
ArberDAWeissLM: 1997, CD10. A review. Appl Immunohistochem5:125–140.
2.
AveryAKBecksteadJRenshawAACorlessCL: 2000, Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol24:203–210.
3.
BuntonTE: 1993, The immunocytochemistry of cytokeratin in fish tissues. Vet Pathol30:418–425.
4.
CampbellDJSmithWT: 1966, A pituitary adenoma in a hedgehog (Erinaceus europaeus). Endocrinology79:842–844.
5.
ChuPArberDA: 2000, Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am J Clin Pathol113:374–382.
6.
CohenAJBunnPAFranklinW: 1996, Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux. Cancer Res56:831–839.
EydenB: 1996, Lamina: fibronexus. In: Organelles in tumor diagnosis: an ultrastructural atlas, ed. EydenB, pp. 146–151. Igaku-Shoin, New York, N.Y.
9.
FisherCCarterRLRamachandraSThomasDM: 1992, Peripheral nerve sheath differentiation in malignant soft tissue tumors: an ultrastructural and immunohistochemical study. Histopathology20:115–125.
10.
FryeFLDutraFR: 1973, Squamous cell carcinoma of the feet of an Indian hedgehog. J Wildl Dis9:249–250.
11.
GrossTLIhrkePJWalderEJ: 1992, Malignant schwannoma. In: Veterinary dermatology, ed. GrossTLIhrkePJWalderEJ, pp. 441–443. Mosby Year Book, St. Louis, MO.
12.
HiroseTHasegawaTKudoE: 1992, Malignant peripheral nerve sheath tumors: an immunohistochemical study in relation to ultrastructural features. Hum Pathol23:865–870.
13.
HiroseTSanoTHizawaK: 1988, Heterogeneity of malignant schwannomas. Ultras Pathol12:107–116.
14.
HrubanZVardimanJMeehanF: 1992, Hematopoietic malignancies in zoo animals. J Comp Pathol106:15–24.
15.
MatsuonoHShimodaTKakimotoS: 1985, Histopathologic and immunohistochemical study of malignant tumors of peripheral nerve sheath (malignant schwannoma). Cancer56: 2269–2279.
16.
McIntoshGGLodgeAJWatsonP: 1999, NCL-CD10-270: a new monoclonal antibody recognizing CD10 in paraffin-embedded tissues. Am J Pathol154:77–82.
17.
PeauroiJRLowenstineLJMunnRJWilsonDW: 1994, Multicentric skeletal sarcomas associated with probable retrovirus particles in two African hedgehogs (Atelerix albiventris). Vet Pathol31:481–484.
18.
Ramos-VaraJABeissenherzM: 2000, Optimization of immunohistochemical methods using two different antigen retrieval methods on formalin-fixed, paraffin-embedded tissues: experience with 63 markers. J Vet Diagn Invest12:307–311.
19.
Ramos-VaraJAMillerMACraftD: 1998, Intestinal plasmacytoma in an African hedgehog. J Wildl Dis34:377–380.
RaymondJTWhiteMR: 1999, Necropsy and histopathologic findings in 14 African hedgehogs (Atelerix albiventris): a retrospective study. J Zoo Wild Med30:273–277.
23.
RaymondJTWhiteMRJanovitzEB: 1997, Malignant mast cell tumor in an African hedgehog (Atelerix albiventris). J Wildl Dis33:140–142.
24.
ReamsRYJanovitzEB: 1992, Oronasal squamous cell carcinoma in an African hedgehog (Erinaceidae albiventris). J Wildl Dis28:148–150.
25.
RosaiJ: 1997, Soft tissues. In: Ackerman's surgical pathology, ed. RosaiJ, 8th ed., pp. 2021–2134. Mosby, St. Louis, MO.
26.
WatsonPWoodKMLodgeA: 2000, Monoclonal antibodies recognizing CD5, CD10 and CD23 in formalin-fixed, paraffin-embedded tissue: production and assessment of their value in the diagnosis of small B-cell lymphoma. Histopathology36:145–150.
