Papillomavirus-induced papillomas were diagnosed on multiple digits of all 4 feet of a young Beagle. No other cutaneous or oral involvement was identified. Papillomavirus antigen was confirmed by im-munoperoxidase localization within keratinocyte nuclei. In addition to the typical basophilic intranuclear inclusions associated with papillomavirus infections, keratinocytes within the papillomas contained large, eosino-philic cytoplasmic inclusions that previously have been described in a Boxer with cutaneous lesions associated with a papillomavirus infection. The papillomas in this Beagle regressed completely within 2 months of the initial diagnosis.
References
1.
BregmanCLHirthRSSundbergJP: 1978, Cutaneous neoplasms in dogs associated with canine oral papilloma virus vaccine. Vet Pathol24:477–487.
2.
CampbellKLSundbergJPGoldschmidtMH: 1988, Cutaneous inverted papillomas in dogs. Vet Pathol25:67–71.
3.
ChambersVCEvansCA: 1959, Canine oral papillomatosis. 1. Virus assay and observations on the various stages of the experimental infection. Cancer Res19:1188–1195.
4.
DavisPEHuxtableRRSabineM: 1976, Dermal papillomas in the racing greyhound. Australas J Dermatol17:13–16.
5.
Le NetJLOrthGSundbergJP: 1997, Multiple pig-mented cutaneous papules associated with a novel canine pap-illoma virus in an immunosuppressed dog. Vet Pathol34:8–14.
6.
NagataMNankoHMoriyamaA: 1995, Pigmented plaques associated with papillomavirus infection in dogs: is this epidermodysplasia verruciformis?Vet Dermatol6:179–186.
SchweglerKWalterJHRudolphR: 1997, Epithelial neoplasms of the skin, the cutaneous mucosa and the transitional epithelium in dogs; an immunolocalization study for papilloma virus antigen. J Vet Med Ser A44:115–123.
9.
SundbergJP: 1992, Papillomaviruses. In: Veterinary diagnostic virology: a practitioner's guide, pp. 148–150. Mosby-Year Book, St. Louis, MO.
10.
SundbergJPJungeRELancasterWD: 1984, Immunoperoxi-dase localization of papillomaviruses in hyperplastic and neoplastic epithelial lesions of animals. Am J Vet Res45:1441–1446.
11.
SundbergJPO'BanionMKSchmidt-DidierE: 1986, Cloning and characterization of a canine oral papillomavirus. Am J Vet Res47:1142–1144.
12.
SundbergJPSmithEKHerronAJ: 1994, Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in a Chinese Shar Pei dog. Vet Pathol31:183–187.
13.
TeifkeJPLohrCVShirasawaH: 1998, Detection of canine oral papillomavirus-DNA in canine oral squamous cell carcinomas and p53 overexpressing skin papillomas of the dog using the polymerase chain reaction and non-radioactive in situ hybridization. Vet Microbiol60:119–130.
14.
WalderEJGrossTL: 1992, Viral squamous papilloma. In: Veterinary dermatopathology: a macroscopic and microscopic evaluation of canine and feline skin disease, pp. 334–335. Mosby-Year Book, St. Louis, MO.
15.
WalderEJGrossTL: 1992, Nailbed epithelial tumors. In: Verinary dermatopathology: a macroscopic and microscopic evaluation of canine and feline skin disease, pp. 399–400. Mosby-Year Book, St. Louis, MO.
