Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease

Abstract

Objectives:

This clinical update review focuses on the management of the neuropsychiatric manifestations of Huntington’s disease (HD). The review highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area.

Conclusions:

Neuropsychiatric symptoms may precede the classic motor clinical symptoms of HD (prodromal HD) by decades and cause significant functional impairment. Early recognition and comprehensive non-pharmacological, usually in combination with pharmacological, treatment is essential.

Keywords

huntington’s disease neuropsychiatric symptoms psychiatry

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References

Chua

Loi

Chiu

Huntington’s disease. In: Ames

Burns

O’Brien

(eds) Dementia, 5th edn. Florida: Taylor & Francis Group, 2016, pp. 868–885.

Loi

Eratne

Kelso

et al . Management of behavioural and psychological symptoms of Alzheimer’s disease. Australas Psychiatr 2018: in press.

Thompson

Cruickshank

Penalililo

et al . The effects of multidisciplinary rehabilitation in patients with early-to-middle stage Huntington’s disease: a pilot study. Eur J Neurol 2013; 20: 1325–1329.

Paulson

Ready

Hamilton

et al . Neuropsychiatric aspects of Huntington’s disease. J Neurosurg Neurol Psychiatr 2001; 71: 310–314.

Cubo

Shannon

Tracy

et al . Effect of donepezil on motor and cognitive function in Huntington’s disease. Neurology 2006; 67: 1268–1271.

de Tommaso

Difruscolo

Sciruicchio

et al . Two years’ follow-up of rivsastigmine treatment in Huntington’s disease. Clin Neuropharmacol 2007; 30: 43–46.

Kieburtz

Landwehrmeyer

Reilmann

et al . Efficacy, safety and tolerability of pridopidine in Huntington’s disease: results from the Phase II, double-blind, placebo-controlled, dose-ranging study, Pride-HD (P2.005). Neurology 2017; 88 (16 Suppl).

Kloberg

Constantinescu

Nilsson

et al . Tolerability and efficacy of the monoaminergic stabilizer NSU6162 in HD: a double-blind cross-over study. Acta Neuropsychiatrica 2014; 26: 298–306.

Reilman

Rouzade-Dominguez

Saft

et al . A randomised placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington’s disease. Mov Disord 2015; 30: 427–431.

10.

Delorme

Rogers

Lau

et al . Deep brain stimulation of the internal pallidum in Huntington’s disease. J Neurol 2016; 263: 290–298.

11.

Philpott

Fitzgerald

Cummins

et al . Transcranial magnetic stimulation as a tool for understanding neurophysiology in Huntington’s disease: a review. Neurosci Biobehav Rev 2013; 37: 1420–1433.

12.

Dunnett

Rosser

. Stem cell transplantation in Huntington’s disease. Exp Neurol 2007; 203: 279–292.

13.

Mason

Barker

Novel targets for Huntington’s disease: future prospects. Degen Neurol Neuromusc Dis 2016; 66: 25–36.

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