The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in community and hospital is increasing. The development of drug resistance may be attributed to the extensive use of antibiotics. Nanotechnology antimicrobial spray (NTAS), a physical antibacterial agent, is an alternative to antibiotic treatment on wound management. We report a case of MRSA associated skin abscess using NTAS in the wound management. NTAS possesses potent, broad spectrum antibacterial effect while carrying no risk of resistance and minimal adverse effect. Moreover, NTAS facilitates home wound management, thus reducing dependency on public health resources. Further studies are indicated to explore the clinical role of NTAS in an attempt to reduce the use of antibiotics. (Hong Kong j.emerg.med. 2011;18:432-436)
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