A 42-year-old air-conditioning technician presented with abdominal pain and influenza like illness eventually developed thrombocytopenia and haemoconcentration with renal impairment shortly after admission. The patient required a section of haemodialysis for acute oliguric renal failure with fluid overload. He developed diuresis and his clinical condition was improved with supportive treatment. Hantaan virus infection with haemorrhagic fever with renal syndrome was confirmed by serologic test.
VapalahtiO., MustonenJ., LundkvistA., HenttonenH., PlyusninA., VaheriA.Hantavirus infections in Europe. Lancet Infect Dis2003; 3(10): 653–61.
2.
ZuckermanA.J., BanatvalaJ.E., GriffithsP., SchoubB., MortimerP.Principle and Practice of Clinical Virology, 6th ed. Wiley-Blackwell; 2009.
3.
GavrilovskayaI.N., BrownE.J., GinsbergM.H., MackowE.R.Cellular entry of Hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta 3 integrins. J Virol1999; 73(5): 3951–9.
4.
LinderholmM., AhlmC., SettergrenB., WaageA., TarnvikA.Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome. J Infect Dis1996; 173(1): 38–43.
5.
KanervaM., VaheriA., MustonenJ., PartanenJ.High-producer allele of tumor necrosis factor alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica. Scand J Infect Dis1998; 30(5): 532–4.
6.
ChangW.K., ChuY.K., LeeS.H., LeeH.W.Study of Haemorrhagic Fever with Renal Syndrome in Hong Kong. J Hong Kong Med Assoc1990; 42(2): 74–6.
7.
Hemorrhagic fever with renal syndromes: Memorandum from a WHO meeting. Bull World Health Organ1983; 61(2): 269–75.
8.
KontkanenM., PusstijarviT., LahdevirtaJ.Myopic shift and its mechanisms in nephropathia epidemica or Puumala virus infection. Br J Ophthalmol1994; 78: 903–6.
9.
McCaugheyC., HartC.A.Hantavirus [review article]. J Med Microbiol2000; 49: 587–99.
10.
Kallio-KokkoH., VapalahtiO., LundkvistA., VaheriA.Evaluation of Puumala virus IgG and IgM enzyme immunoassays based on recombinant baculovirus-expressed nucleocapsid protein for early nephropathia epidemica diagnosis. Clin Diagn Virol1998; 10(1): 83–90.
11.
HugginsJ.W., HsiangC.M., CosgriffT.M., GuangM.Y., SmithJ.I., WuZ.O.Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. J Infect Dis1991; 164(6): 1119–27.
12.
RascheF.M., UhelB., KrugerD.H., CzockD., HamplW., KellerF.Thrombocytopenia and Acute Renal Failure in Pummala Hantavirus infections. Emerging Infectious Disease2004: (10)8; 1420–5.
13.
KimY.K., LeeS.C., KimC., HeoS.T., ChoiC., KimJ.M.Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus. J Infect2007; 54(4): 381–6.
