Synthesis,spectral analysis and anti-cancer activity of N-((4H-1,2,3 – triazole-4-yl)methyl-4-benzylaniline

Abstract

A thorough guide to the design and high-yield synthesis of 1,2,3-triazole derivatives using a variety of chemicals, bases, and catalysts is presented in this study. The approach is straightforward, effective, and efficient. Amide coupling reagents have been developed that are more convenient, milder, and allow for higher selectivity under mild conditions. 4-benzyl aniline (I) treated with propargyl bromide and K₂CO₃, DMF to form compound (II), compound (II) reacts with alkyl azide(III) and CuI / DHQ D₂. The derivatives of IV a-l have been shown moderate to excellent efficacy when tested for anticancer properties against several cancer cell lines. The MCF-7 cell line is the most resistant to compounds IV a and IV e, with an IC₅₀ values of 1.72 and 1.54 respectively. The structures of the newly synthesised compounds have been established by ¹H and ¹³C NMR, IR and ESI-HRMS.