Male rats, put on 15 g/day low calorie and/or low protein diets for three weeks, were subjects in a study to determine lethal doses of organic solvents, heavy metals and agricultural chemicals. Protein-calorie malnutrition enhanced tolerance to organic solvents and heavy metals, except for methylparathion. However, tolerance to environmental pollutants was down to ordinary levels in a hot environment (32°C) despite the beneficial effects of protein-calorie malnutrition. Toxic effects of repeated exposure to benzene were aggravated by protein-calorie malnutrition in a hot environment.
1. Baetjer AM, Smith R: Effect of environmental temperature on reaction of mice to parathion, an anticholinesterase agent, Am J Physiol1956; 186:39–46.
2.
2. Baetjer AM, Joardar SND, McQuary WAM: Effects of environmental temperature and humidity on lead poisoning in animals.Arch Environ Hlth1960; 1:463–77.
3.
3. Nomiyama K, Matsui K, Nomiyama H: Acute toxicities of beryllium in mice at different environmental temperature.Jpn J Ind Hlth1978; 20:384–5.
4.
4. Nomiyama K, Nomiyama H, Taguchi T: Effects of environmental temperatures on the toxicity of cadmium in mice. In: Proc. 8th Asian Conf. on Occupational Health, Jpn. Industr. Safety Assoc., Tokyo.1978, 221–5.
5.
5. Matsui K, Nomiyama K: Effects of environmental temperatures on the cadmium-induced testicular injury.Jpn J Hyg1979;34:620–3.
6.
6. Nomiyama K, Matsui K, Nomiyama H: Effects of temperature and other factors on the toxicity of methylmercury in mice.Toxicol Appl Pharmacol1980; 56:392–8.
7.
7. Nomiyama K, Matsui K, Nomiyama H: Environmental temperature, a factor modifying the acute toxicity of organic solvents, heavy metals, and agricultural chemicals.Toxicol Letters1980; 6:67–70.
8.
8. Nomiyama K: Effects of environmental temperatures on toxicity of environmental pollutants.Rodo no Kagaku1979; 34:29–34.
9.
9. McLean AEM, McLean EK: Diet and toxicity, Br Med Bul1969;25:278–81.
10.
10. Subcommittee on Laboratory Animal Nutrition of National Research Council: In: Nutrient Requirements of Laboratory Animals.Washington, National Academy of Sciences, 1972.
11.
11. Deichman WmB, LeBlanc TJ: Determination of the approximate lethal dose with about six animals.J Ind Hyg Toxicol1943; 25:415–7.
12.
12. Nomiyama K: Studies on poisoning by benzene and its homologues (7): Toxicity of benzene metabolites to hemopoiesis.Industr Hlth1965;3:53–7.
