This study evaluated the relationships between parity and the age at menopause and menopausal syndrome among Chinese women in Gansu. A total of 7236 women aged 40 to 55 years met study eligibility criteria. The modified Kupperman Menopausal Index scale was used to assess the severity of menopausal syndrome. Cox regression was applied to estimate hazard ratio and 95% confidence interval, and logistic regression was performed to calculate odds ratio and confidence interval. The mean age at menopause was 47.91 ± 3.31 years. There is no relationship between parity and age at menopause. Women with nulliparity or multiparity seemed to have higher risks of moderate and severe menopausal syndrome. The potential beneficial effects of one or two births on menopausal syndrome were also observed by applying the multivariable logistic regression analysis, particularly in urogenital symptoms. Women with nulliparity and multiparity appeared to be at the higher risks of menopause syndrome.
HallajzadehJKhoramdadMIzadiN, et al. Metabolic syndrome and its components in premenopausal and postmenopausal women: a comprehensive systematic review and meta-analysis on observational studies. Menopause. 2018;25:1155-1164.
2.
GeorgakisMKBeskou-KontouTTheodoridisISkalkidouAPetridouET.Surgical menopause in association with cognitive function and risk of dementia: a systematic review and meta-analysis. Psychoneuroendocrinology. 2019;106:9-19.
3.
RozenbergSVandrommeJ.Attitudes to the prescription of menopause hormone therapy for vasomotor symptoms and osteoporosis for patients of different ages: a survey of gynecologists in Belgium. Maturitas. 2019;128:60-63.
4.
LiLWuJPuD, et al. Factors associated with the age of natural menopause and menopausal symptoms in Chinese women. Maturitas. 2012;73:354-360.
5.
LayAARdo NascimentoCFHortaBLFilhoADPC. Reproductive factors and age at natural menopause: a systematic review and meta-analysis. Maturitas. 2020;131:57-64.
6.
GoldEBCrawfordSLAvisNE, et al. Factors related to age at natural menopause: longitudinal analyses from SWAN. Am J Epidemiol. 2013;178:70-83.
7.
KlingbergSBrekkeHKWinkvistAEngströmGHedbladBDrakeI.Parity, weight change, and maternal risk of cardiovascular events. Am J Obstet Gynecol. 2017;216:172.e1-172.e15.
8.
ChoiJIHanKDKimSJKimMJShinJELeeHN.Relationship between delivery history and health-related quality of life in menopausal South Korean women: the Korea National Health and Nutrition Examination Surveys. Maturitas. 2016;92:24-29.
9.
NanriAMizoueTNodaM, et al. Menstrual and reproductive factors and type 2 diabetes risk: the Japan Public Health Center-based Prospective Study. J Diabetes Investig. 2019;10:147-153.
10.
GuanHBWuQJGongTT.Parity and kidney cancer risk: evidence from epidemiologic studies. Cancer Epidemiol Biomarkers Prev. 2013;22:2345-2353.
11.
GuoPXuCZhouQ, et al. Number of parity and the risk of gallbladder cancer: a systematic review and dose-response meta-analysis of observational studies. Arch Gynecol Obstet. 2016;293:1087-1096.
12.
Dung YunTPMello-ThomsCPeatJK, et al. Associations of breast density with demographic, reproductive, and lifestyle factors in a developing Southeast Asian population. Asia Pac J Public Health. 2017;29:377-387.
13.
TaoMShaoHLiCTengY.Correlation between the modified Kupperman Index and the Menopause Rating Scale in Chinese women. Patient Prefer Adherence. 2013;7:223-229.
14.
HarlowSDGassMHallJE, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Fertil Steril. 2012;97:843-851.
15.
IslamMRGartoullaPBellRJFradkinPDavisSR.Prevalence of menopausal symptoms in Asian midlife women: a systematic review. Climacteric. 2015;18:157-176.
16.
SchoenakerDAJMJacksonCARowlandsJVMishraGD. Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents. Int J Epidemiol. 2014;43:1542-1562.
17.
SantoroNBrockwellSJohnstonJ, et al. Helping midlife women predict the onset of the final menses: SWAN, the Study of Women’s Health Across the Nation. Menopause. 2007;14(3pt 1):415-424.
18.
HvidmanHWBentzenJGThuesenLL, et al. Infertile women below the age of 40 have similar anti-Mullerian hormone levels and antral follicle count compared with women of the same age with no history of infertility. Hum Reprod. 2016;31:1034-1045.
19.
GibbsCMWendtAPetersSHogueCJ.The impact of early age at first childbirth on maternal and infant health. Paediatr Perinat Epidemiol. 2012;26(suppl 1):259-284.
20.
MishraGDPandeyaNDobsonAJ, et al. Early menarche, nulliparity and the risk for premature and early natural menopause. Hum Reprod. 2017;32:679-686.
21.
BotleroRDavisSRUrquhartDMShortreedSBellRJ.Age-specific prevalence of, and factors associated with, different types of urinary incontinence in community-dwelling Australian women assessed with a validated questionnaire. Maturitas. 2009;62:134-139.
22.
GeJYangPZhangYLiXWangQLuY.Prevalence and risk factors of urinary incontinence in Chinese women: a population-based study. Asia Pac J Public Health. 2015;27:NP1118-NP1131.
23.
NelsonDBSammelMDPattersonFLinHGraciaCRFreemanEW.Effects of reproductive history on symptoms of menopause: a brief report. Menopause. 2011;18:1143-1148.
24.
YenielAOErgenogluAMAskarNItilIMMeseriR.How do delivery mode and parity affect pelvic organ prolapse?Acta Obstet Gynecol Scand. 2013;92:847-851.
25.
AwwadJSayeghRYeretzianJDeebME.Prevalence, risk factors, and predictors of pelvic organ prolapse: a community-based study. Menopause. 2012;19:1235-1241.
26.
PalmaFVolpeAVillaPCagnacciA; Writing Group of AGATA Study. Vaginal atrophy of women in postmenopause. Results from a multicentric observational study: the AGATA study. Maturitas. 2016;83:40-44.
27.
NappiREKokot-KierepaM.Vaginal health: insights, views & attitudes (VIVA)—results from an international survey. Climacteric. 2012;15:36-44.
28.
NappiREPalaciosSPanayNParticcoMKrychmanML.Vulvar and vaginal atrophy in four European countries: evidence from the European REVIVE Survey. Climacteric. 2016;19:188-197.
29.
Crean-TateKKFaubionSSPedersonHJParticcoMKrychmanML.Management of genitourinary syndrome of menopause in female cancer patients: a focus on vaginal hormonal therapy. Am J Obstet Gynecol. 2020;222:103-113.
30.
SrisukhoSPantasriTPiyamongkolWPhongnarisornCMorakoteN.The experience of genitourinary syndrome of menopause (GSM) among Thai postmenopausal women: the non-reporting issue. Int Urogynecol J. 2019;30:1843-1847.
31.
KienVDJatTRPhuTV, et al. Trends in socioeconomic inequalities in the use of antenatal care services by women aged 15 to 49 years in Vietnam. Asia Pac J Public Health. 2019;31:413-421.
32.
HardhantyoMChuangYC.Multilevel factors associated with pregnancy-related health behaviors in Indonesia: evidence from the 2007, 2012, and 2017 Indonesian Demographic Health Surveys. Asia Pac J Public Health. 2020;32:81-90.
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