We performed a meta-analysis of the correlation between drinking green tea and the risk of female ovarian tumors. Related literature (2000-2010) was retrieved from PubMed, EMbase, CBMdisc, CNKI, and Wanfang databases. The relationship between the prevalence of ovarian cancer and drinking tea in cohort studies was explored. RevMan5.1.0 software was used for the meta-analysis. A total of 6 case control studies and cohort studies were included. A total of 9113 participants, 3842 cases, and 5271 control cases were included in our analysis. Our analysis indicates that drinking green tea can significantly decrease the risk of ovarian cancer (odds ratio = 0.81; 95% confidence interval = 0.73-0.89; P < .0001). Further research is needed to explore the relationship between drinking green tea and the risk of ovarian tumor in different groups of people and with different tea types and dosages.
WhitehouseCSolomonE. Current status of the molecular characterization of the ovarian cancer antigen CAl25 and implications for its use in clinical screening. Gynecol Oncol. 2003;88(1, pt 2):S152-S157.
StewartBWKleihuesP. International Agency for Research on Cancer: World Cancer Report. Lyon, France: IARC Press; 2003.
5.
FuemmelerBFPendzichMKTercyakKP. Weight, dietary behavior, and physical activity in childhood and adolescence: implications for adult cancer risk. Obes Facts. 2009;2:179-186.
6.
RieckGFianderA. The effect of lifestyle factors on gynaecological cancer. Best Pract Res Clin Obstet Gynaecol. 2006;20(2):227-51.
7.
YangCSWangXLuG. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer. 2009;9:429-439.
8.
ChungFLSchwartzJHerzogCR. Tea anti cancer prevention: studies in animals and humans. J Nutr. 2003;133:3268S-3274S.
9.
YangCSMaliakalPMengX. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol. 2002;42:25-54.
10.
WardNCTsaiIJBardenA. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension. 2008;51:1393-1398.
11.
LichtensteinMJMnlrowCDElwoodPC. Guidelines for reading case-control studies. J Chronic Dis. 1987;40:893-903.
12.
SongYJKristalARWicklundKG. Coffee, tea, colas, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:712-716.
13.
XuFLZhangMBinnsCWLeeAH. A case control study of ovarian cancer and drinking. J Shihezi Univ (Nat Sci). 2006;24:469-47l.
14.
NagleCMOlsenCMBainCJ. Tea consumption and risk of ovarian cancer. Cancer Causes Control. 2010;21:1485-1491.
15.
ZhangMBinnsCWLeeAH. Tea consumption and ovarian cancer risk: a case-control study in China. Cancer Epidemiol Biomarkers Prey. 2002;11(8):713-718.
16.
KakutaYNakayaNNagaseS. Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Causes Control. 2009;20:617-624.
17.
GaoJXiangYBXuWH. Green tea consumption and the risk of endometrial cancer: a population-based case-control study in urban Shanghai. Zhonghua Liu Xing Bing Xue Za Zhi. 2005;26:323-327.
18.
SteevensJSchoutenLJVerhageBA. Tea and coffee drinking and ovarian cancer risk: results from the Netherlands Cohort Study and a meta-analysis. Br J Cancer. 2007;97:1291-1294.
19.
ZhouBYangLWangL. The association of tea consumption with ovarian cancer risk: a metaanalysis. Am J Obstet Gynecol. 2007;197:594.el-594.e6.
20.
LeeKWLeeHJLeeCY. Antioxidant activity of black tea vs. green tea. J Nutr. 2002;132:785, author reply 6.
21.
SpinellaFRosanoLDecandiaS. Antitumor effect of green tea polyphenol epigallocatechin-3-gallate in ovarian carcinoma cells: evidence for the endothelin-1 as a potential target. Exp Biol Med (Maywood). 2006;231:1123-1127.
22.
SpinellaFRosanoLDi CastroV. Green tea polyphenol epigalloeatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma. Mol Cancer Ther. 2006;5:1483-1492.
23.
ChanMMSopranoKJWeinsteinK. Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility. J Cell Physiol. 2006;207:389-396.
24.
LanssonSCWolkA. Tea consumption and ovarian cancer risk in a population-based cohort. Arch Intern Med. 2005;165:2683-2686.
