This article presents a summary of the current knowledge gaps and research questions related to care of normal newborn, neonatal transport, hypoglycemia, CPAP, cranial ultrasonography and blood component therapy.
HuttonEileen K, HassanEman S. Late vs Early clamping of the umbilical cord in Full-term Neonates Systematic review and Meta-analysis of controlled trials. JAMA2007;297: 1241–52.
2.
McDonaldSJ, MiddletonP.Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst Rev.2008 Apr 16; (2):CD004074.
3.
AliZ, KhadijeD, ElaheA, MohammadM, FatemeZ, NargesZ.Prophylaxis of ophthalmia neonatorum comparison of betadine, erythromycin and no prophylaxis. J Trap Pediatr.2007 Dec;53(6):388–92.
4.
RichterR, BelowH, KadowI, KramerA, MüllerC, FuschC.Effect of topical 1.25% povidone-iodine eyedrops used for prophylaxis of ophthalmia neonatorum on renal iodine excretion and thyroid-stimulating hormone level. J Pediatr.2006 Mar;148(3):401–3.
5.
IsenbergSJ, AptL, WoodM.A controlled trial of povidone-iodine as prophylaxis against ophthalmia neonatorum. N Engl J Med.1995 Mar 2;332(9):562–6.
6.
SolankiK, MatnaniM, KaleM, JoshiK, BavdekarA, BhaveS, PanditA.Transcutaneous absorption of topically massaged oil in neonates. Indian Pediatr.2005;42: 998–1005.
7.
SankaranarayananK, MondkarJA, ChauhanMM, MascarenhasBM, MainkarAR, SalviRY.Oil massage in neonates: an open randomized controlled study of coconut versus mineral oil. Indian Pediatr.2005, 42: 877–84.
8.
MarkestadT, KolmannskogS, ArntzenE, ToftegaardL, HanebergB, AksnesL.Serum concentrations of vitamin D metabolites in exclusively breast-fed infants at 70 degrees north. Acta Paediatr Scand.1984 Jan;73(1):29–32.
9.
ZieglerEE, HollisBW, NelsonSE, JeterJM.Vitamin D deficiency in breastfed infants in Iowa. Pediatrics.2006 Aug;118(2):603–10.
10.
KattwinkelJ, BrooksJ, MyerbergD; American Academy of Pediatrics, Task Force on Infant Positioning and SIDS. Positioning and SIDS. Pediatrics1992;89: 1120–6.
11.
BrownS, SmallR, ArgusB, DavisPG, KrastevA.Early postnatal discharge from hospital for healthy mothers and term infants. Cochrane Database of Systematic Reviews2002, Issue 3. Art. No.: CD002958.
12.
DayS, McCloskeyK, OrrR. Pediatric interhospital critical care transport: consensus of a national leadership conference. Pediatrics1991;4: 696–704.
13.
LeeSK, ZupancicJAF, SaleJ. Cost-effectiveness and choice of infant transport systems. Med Care2002; 40: 705–716.
14.
LeeSK, ZupancicJAF, PendrayMR. Transport risk index of physiologic stability: a practical system for assessing infant transport care. J Pediatr2001;139: 220–226.
15.
BomontRK, CheemaIU.Use of nasal continuous positive airway pressure during neonatal transfers. Arch Dis Child Fetal Neonatal Ed2006;91:F85–F89. doi: 10.1136/adc.2005.078022
16.
JohannigmanJA, BransonRD, JohnsonDJ, DavisKJr, HurstJM.Out-of-hospital Ventilation: Bag-Valve Device vs Transport Ventilator. Acad Emerg Med.1995 Aug; 2(8):719–724.
17.
The OSIRIS Collaborative Group.Early versus delayed neonatal administration of a synthetic surfactant – the judgment of OSIRIS. Lancet1992;340: 1363–9.
18.
CostakosD, AllenD, KraussA. Surfactant therapy prior to interhospital transport of preterm infants. Am J Perinatol.1996;13: 309–16.
19.
MildenhallLF, PavuluriNN, BowmanED.Safety of synthetic surfactant use before preterm newborn transport. J Paediatr Child Health1999;35: 530–535.
10. CornblathM, SchwartzR, Aynsley-GreenA, LloydJK. (Editors – A Ciba Foundation Discussion Meeting) Hypoglycemia in infancy: the need for a rational definition. Pediatrics1990;85: 834–7.
23.
World Health Organization.Hypoglycemia of the newborn: review of the literature. Geneva, WHO/CHD/97.1;1997: 1–55.
24.
SrinivasanG, PildesRS, CattamanchiG, VooraS, LilienL.Plasma glucose values in normal neonates: a new look. J Pediatrics1986;109: 114–7.
25.
TanzerF, YazarN, YazarH, IcagansiogluD.Blood glucose levels and hypoglycemia in full term neonates during the first 48 hours of life. J Tropical Pediatr1997;43: 58–60.
26.
HawdonJM, Ward PlattMP, Aynsley-GreenA.Patterns of metabolic adaptation for preterm and term infants in the first neonatal week. Arch Dis Child1992, 67: 357–65.
27.
BoluytN, van KempenA, OffringaM.Neurodevelopment after neonatal hypoglycemia: a systematic review and design of an optimal future study. Pediatrics.2006;117(6):2231–43.
28.
SubramaniamP, Henderson-SmartDJ, DavisPG.Prophylactic nasal continuous positive airway pressure for preventing morbidity and mortality in very preterm infants. Cochrane Database Syst Rev2005: CD001243.
SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network, FinerNN, CarloWA, WalshMC, RichW, GantzMG, LaptookAR, YoderBA, FaixRG, DasA, PooleWK, DonovanEF, NewmanNS, AmbalavananN, FrantzID3rd, BuchterS, SánchezPJ, KennedyKA, LaroiaN, PoindexterBB, CottenCM, Van MeursKP, DuaraS, NarendranV, SoodBG, O'SheaTM, BellEF, BhandariV, WatterbergKL, HigginsRD.Early CPAP versus surfactant in extremely preterm infants. N Engl J Med2010;362(21): 1970–9. Erratum in: N Engl J Med. 2010;362(23):2235.
31.
SandriF, PlavkaR, AncoraG, SimeoniU, StranakZ, MartinelliS, MoscaF, NonaJ, ThomsonM, VerderH, FabbriL, HallidayH; CURPAP Study Group. Prophylactic or early selective surfactant combined with nCPAP in very preterm infants. Pediatrics2010;125(6):e1402–9.
32.
MorleyCJ, DavisPG, DoyleLW, BrionLP, HascoetJM, CarlinJB; COIN Trial Investigators. Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med.2008;358(7):700–8. Erratum in: N Engl J Med. 2008;358(14):1529.
33.
StevensTP, BlennowM, SollRF.Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome. Cochrane Database Syst Rev2007:CD003063.
34.
De PaoliAG, DavisPG, FaberB, Morleya.Devices and pressure sources for administration of nasal continuous positive airway pressure (NCPAP) in preterm neonates. Cochrane Database Syst Rev.2008 Jan 23, (1):CD002977.
35.
KirpalaniH, WhyteRK, AndersenC.The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr2006, 149:301.
36.
Fetus and Newborn Committee, Canadian Paediatric Society (CPS).Red blood cell transfusions in newborn infants:Revised guidelines Paediatrics & Child Health2002;7(8):553–8.
37.
BoultonF.Transfusion guidelines for neonates and older children. Brit J Haemat2004; 124: 433–453.