Identification of CD18 as a novel Taxol binding/signaling protein in murine macrophage membranes

Abstract

The anti-tumor agent, Taxol, is a potent LPS mimetic in murine macrophages, an activity that is dissociable from its well-characterized anti-mitotic activity which is mediated by microtubule hyperstabilization. A photoactivatable Taxol analog was used to identify components of a putative, shared LPS signaling apparatus in murine macrophage membranes. We report here that CD18, the β chain of the β₂-integrin, Mac-1, represents a major Taxol binding protein in murine macrophages.

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