Sage Journals: Discover world-class research

Abstract

The local Schwartzman phenomenon is a thrombotic hemorrhagic reaction that develops in response to local preparatory administration followed by intravenous provoking injection of endotoxin. This study investigated permeability of coronal dentin to endotoxin. Cavities were prepared in human dentin discs and received either 10 μg or 100 μg Salmonella enteritidis endotoxin or pyrogen-free water over the cavity floor. The cavities were then restored with a glass ionomer cement. The discs were implanted in rabbits' abdominal skin. The rabbits also received intradermal injections of 10 μg and 100 μg endotoxin and pyrogen-free water. 18 h after implantation/injection, a provoking intravenous injection of endotoxin was administered and the animals were terminated 6 h later. Intradermal injection of both doses of endotoxin elicited LSP in all rabbits. In the majority of specimens, endotoxin at 10 μg and 100 μg dosage did not permeate dentin to elicit LSP.

Get full access to this article

View all access options for this article.

References

Phillips R.W. , Science of Dental Materials. 9th edn. Philadelphia: W.B. Saunders, 1991 ; 61.

Bergenholtz G. , Lindhe J. Effect of soluble plaque factors on inflammatory reactions in the dental pulp. Scand J Dent Res 1975; 83: 153-158.

Bergenholtz G. , Warfvinge J. Migration of leukocytes in dental pulp in response to plaque bacteria. Scand J Dent Res 1982; 90: 354-362.

Warfvirige J. , Bergenholtz G. Healing capacity of human and monkey dental pulps following experimentally-induced pulpitis. Endod Dent Traumatol 1986; 2: 256-262.

Warfvinge J. , Bergenholtz G. Dental pulp response to bacterial cell wall material. J Dent Res 1985; 64: 1046-50.

Pashley D.H. , Horner J.A. , Brewer P.D. Interactions of conditioners on the dentin surface. Oper Dent 1992; 5: 137-150.

Pashley D.H. Smear layer: overview of structure and function . Proc Finn Dent Soc 1992; 88: 216-224.

Michelich V.J. , Shuster G.S. , Pashley D.H. Bacterial penetration of human dentin in vitro. J Dent Res 1980; 59: 1398-1403.

Olgart L. , Brännström M. , Johnson G. Invasion of bacteria into dentinal tubules. Acta Odontol Scand 1974; 32: 61-70.

10.

Brännström M. Sensitivity of dentine. Oral Surg Oral Med Oral Pathol 1966; 21: 517-526.

11.

Bertolatti R.L. Conditioning of the dentin substrate. Oper Dent 1992; 5: 131-136.

12.

Davis H.L. , Wieczkowski G. , Yu X.Y. , Joynt R.B. , Gallo J. Adhesion of dentin bonding agents after smear layer treatments. Am J Dent 1992; 5: 29-32.

13.

Shwartzman G. Phenomenon of local skin reactivity to culture filtrates of various microorganisms. Proc Soc Exp Biol Med 1928; 26: 207-208.

14.

Shwartzman G. A new phenomenon of local skin reactivity to b typhosus culture filtrate. Proc Soc Exp Biol Med 1928; 25: 560.

15.

Shwartzman G. Preparation of B typhosus toxic substances for local skin reactivity. Proc Soc Exp Biol Med 1929; 26: 843-844.

16.

Lee L. , Stetson C.A. The local and generalized Shwartzman phenomena. In: Zweifach B.W , Grant L. , McCluskey R.T. eds The Inflammatory Process . New York: Academic Press, 1965; 791-817.

17.

Mustard J.F. , Packham M.A. The reaction of blood to injury. In: Movat H.Z. ed Inflammation, Immunity and Hypersensitivity 2nd edn. Maryland: Harper and Row, 1979; 637-638.

18.

Rizzo A.A. , Mergenhagen S.E. Histopathologic effects of endotoxin injected into rabbit oral mucosa . Arch Oral Biol 1964; 9: 659-670.

19.

Pashley D.H. Clinical correlations of dentin structure and function. J Prosthet Dent 1991; 66: 777-781.

20.

Pashley D.H. , Horner J.A. , Brewer P.D. Interactions of conditioners on the dentin surface. Oper Dent 1992; 5: 137-150.

21.

Gaintantzopoulou M.D. , Willis G.P. , Bricker S.L. , Kafrawy A.H. The local Schwartzman phenomenon and the rabbit's incisor dental pulp. J Dent Res 1993 ; 72 (IADR Abstracts): 126.

The local Schwartzman phenomenon and human dentin permeability to endotoxin

Abstract

Get full access to this article

References