Conformation of lipid A,the endotoxic center of bacterial lipopolysaccharide

Rietschel E.T. , Kirikae T. , Schade F.U. et al. Bacterial endotoxin: Molecular relationships of structure to activity and function. FASEB J 1994; 8: 217-225.

Galanos C. , Lüderitz O. , Westphal O. A new method for the extraction of R lipopolysaccharides. Eur J Biochem 1969; 9: 245-249.

Rietschel E.T. , Brade H. , Holst O. et al. Bacterial endotoxin: chemical constitution, biological recognition, host response, and immunological detoxification. Curr Top Microbiol Immunol 1996; 216:39-81.

Leeson M.C. , Fujihara Y. , Morrison D.C. Evidence for lipopolysaccharide as the predominant proinflammatory mediator in supernatants of antibiotic-treated bacteria. Infect Immun 1994; 62: 4975-4980.

Johnston C.A. , Greisman S.E. Endotoxemia induced by antibiotic therapy: a mechanism for adrenal corticosteroid protection in gram-negative sepsis . Trans Assoc Am Phys 1984; 97: 172-181.

Shenep J.L. , Barton R.P. , Morgan K.A. Role of antibiotic class in the rate of liberation of endotoxin during therapy for experimental gram-negative sepsis. J Infect Dis 1985; 151: 1012-1018.

Z Israelachvili J.N. , Marcelja S. , Horm R.G. Physical principles of membrane organisation. QRev Biophys 1980; 13: 121-200.

Seydel U. , Brandenburg K. Conformations of endotoxin and their relationship to biological activity. In: Novotny A. , Spitzer J.J. , Ziegler E.J. Eds. Cellular and Molecular Aspects of Endotoxin Reactions. Amsterdam: Elsevier, 1990; 61-71.

Seydel U. , Brandenburg K. Supramolecular structure of lipopolysaccharides and lipid A. In: Morrison D.C. , Ryan J. Eds. Bacterial Endotoxic Lipopolysaccharides. Bota Racon: CRC Press, 1992; 225-250.

Brandenburg K. , Seydel U. Investigations into the fluidity of lipopolysaccharide and free lipid A membrane systems by Fourier-transform infrared spectroscopy and differential scanning calorimetry. Eur J Biochem 1990; 191: 229-236.

Seydel U. , Labischinski H. , Kastowsky M. , Brandenburg K. Phase behaviour, supramolecular structure, and molecular conformation of lipopolysaccharide . Immunobiology 1993; 187: 191-211.

Brandenburg K. , Mayer H. , Koch M.H.J. , Weckesser J. , Rietschel E.T. , Seydel U. Influence of the supramolecular structure of free lipid A on its biological activity. Eur J Biochem 1993; 218: 555-563.

Seydel U. , Brandenburg K. , Koch M.H.J. , Rietschel E.T. Supramolecular structure of lipopolysaccharide and free lipid A under physiological conditions as determined by synchrotron small-angle X-ray diffraction. Eur J Biochem 1989; 186: 325-332.

Brandenburg K. , Koch M.H.J. , Seydel U. Phase diagram of lipid A from Salmonella minnesota and Escherichia coli rough mutant lipopolysaccharide. J Struct Biol 1990; 105: 11-21.

Brandenburg K. , Koch M.H.J. , Seydel U. Phase diagram of deep rough mutant lipopolysaccharide from Salmonella minnesota R595. J Struct Biol 1992; 108: 93-106.

Seydel U. , Koch M.H.J. , Brandenburg K. Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota. J Struct Biol 1993; 110: 232-243.

Rietschel E.T. , Brade L. , Holst O. et al. Molecular structure of bacterial endotoxin in relation to bioactivity . In: Nowotny A. , Spitzer J.J. , Ziegler E.J. Eds. Cellular and Molecular Aspects of Endotoxin Reactions. Amsterdam: Elsevier, 1990; 15-32.

Rietschel E.T. , Kirikae T. , Loppnow H. et al. Molecular aspects of the chemistry and biology of endotoxin. In: Sies H. , Flohé L. , Zimmer G. Eds. Molecular Aspects ofinflammation. Berlin: Springer-Verlag, 1991; 207-231.

Brandenburg K. , Schromm A.B. , Koch M.H.J. et al. Conformation and fluidity of endotoxins as determinants of biological activity. In: Levin J. , Alving C.R. , Munford R.S. , Redl H. Eds. Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy . New York: John Wiley, 1995; 167-182.

Seydel U. , Brandenburg K. , Rietschel E. T. A case for an endotoxic conformation. Prog Clin Biol Res 1994; 388: 17-30.

Ramadas Bhat.U. , Carlson R.W. , Busch M. , Mayer H. Distribution and phylogenetic significance of 27-hydroxyoctacosanoic acid in lipopolysaccharides from bacteria belonging to the alpha-2 subgroup of Proteobacteria. Int J Syst Bacteriol 1991; 41: 213-217.

Mayer H. , Krauss J.H. , Yokota A. et al. Natural variants of lipid A. In: Friedman H. , Klein T.W. , Nakano M. , Nowotny A. Eds. Endotoxin. New York: Plenum, 1990; 45-70.

Takayama K. , Qureshi N. , Ribi E. , Cantrell J.L. Separation and characterization of toxic and nontoxic forms of lipid A. Rev Infect Dis 1984; 6: 439-443.

Alving C.R. Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants. Immunobiology 1993; 187: 430-446.

Kiener P.A. , Marek F. , Rodgers G. , Lin P-F. , Warr G. , Desiderio J. Induction of tumor necrosis factor, IFN-gamma, and acute lethality of mice by toxic and non-toxic forms of lipid A. J Immunol 1988 ; 141: 870-874.

Loppnow H. , Libby P. , Freudenberg M. , Krauss J.H. , Weckesser J. , Mayer H. Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS. Infect Immun 1990; 58: 3743-3750.

Moran A.P. Biological and serological characterization of Campylobacter jejuni lipopolysaccharides with deviating core and lipid A structures. FEMS Immunol Med Microbiol 1995; 11: 121-130.

Schromm A.B. , Brandenburg K. , Rietschel E.T. , Seydel U. Do endotoxin aggregates intercalate into phospholipid membranes in a nonspecific, hydrophobic manner? J Endotoxin Res 1995; 2: 313-323

Takayama K. , Mitchell D.H. , Din Z.Z. , Mukerjee P. , Li C. , Coleman D.L. Monomeric Re lipopolysaccharide from Escherichia coli is more active than the aggregated form in the Limulus amebocyte lysate assay and in inducing Egr-1 mRNA in murine peritoneal macrophages. J Biol Chem 1994; 269: 2241-2244.

Gegner J.A. , Ulevitch R.J. , Tobias P.S. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J Biol Chem 1995; 270: 5320-5326.

Lynn W.A. , Liu Y. , Golenbock D.T. Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide. Infect Immun 1993; 61:4452-4461.