Calculating therapeutic indices and therapeutic advantages for endotoxins and monophosphoryl lipid A: an evaluation of data from the scientific literature

Abstract

This review article addresses the question of whether or not monophosphoryl lipid A offers a therapeutic advantage over smaller doses of endotoxin. Biological data were collected from a literature review and these were used to calculate therapeutic indices for monophosphoryl lipid A and endotoxin. Subsequent calculations yielded results which showed that, in humans and in other animals, monophosphoryl lipid A did have a therapeutic advantage over smaller doses of endotoxin.

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