The p50-homodimer mechanism in tolerance to LPS

Blackwell TS , Blackwell TR , Christman JW Induction of endotoxin tolerance depletes nuclear factor-κB and suppresses its activation in rat alveolar macrophages . J Leukoc Biol 1997; 62: 885—891.

Shames BD , Meldrum DR , Selzman CH et al. Increased levels of myocardial IkappaB-alpha protein promote tolerance to endotoxin. Am J Physiol 1998; 275: H1084—H1091.

Kohler NG , Joly A. The involvement of an LPS inducible IκB kinase in endotoxin tolerance . Biochem Biophys Res Commun 1997; 232: 602—607.

Li, Cusart S , Hu J. et al. Characterisation of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells. J Biol Chem 2000; 275: 23340—23345.

Nomura F. , Akashi S. , Sakao Y. et al. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression . J Immunol 2000; 164: 3476—3479.

Coffee KA , Halushka PV , Ashton SH et al. Endotoxin tolerance is associated with altered GTP-binding protein function. J Appl Physiol 1992; 73: 1008—1013.

Durando MM , Meier KE , Cook JA Endotoxin activation of mitogen-activated protein kinase in THP-1 cells; diminished activation following endotoxin desensitization. J Leukoc Biol 1998; 64: 259—264.

Kraatz J. , Clair L. , Rodriguez JL et al. In vitro macrophage endotoxin tolerance: defective in vitro macrophage map kinase signal transduction after LPS pretreatment is not present in macrophages from C3H/HeJ endotoxin resistant mice. Shock 1999; 11: 58—63.

Medvedev AE , Kopydlowski KM , Vogel SN Inhibition of lipopolysaccharide-induced signal transduction in endotoxintolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J Immunol 2000; 165: 2729—2737.

Ziegler-Heitbrock Hwl , Wedel A. , Schraut W. et al. Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers . J Biol Chem 1994; 269: 17001—17004.

Frankenberger M. , Ziegler-Heitbrock Hwl. LPS tolerance in monocyte/macrophages: three 3′ cytosines are required in the DNA binding motif for detection of up-regulated NF-κB p50 homodimers. Immunobiology 1997; 198: 81—90.

Kastenbauer S. , Ziegler-Heitbrock HW NF-kappaB1 (p50) is up-regulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression . Infect Immun 1999; 67: 1553—1559.

Goldring CE , Reveneau S. , Pinard D. et al. Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric oxide synthase gene. Eur J Immunol 1998; 28: 2960—2970.

Bohuslav J. , Kravchenko VV , Parry GC et al. Regulation of an essential innate immune response by the p50 subunit of F-kappaB. J Clin Invest 1998; 102: 1645—1652.

Liu H. , Sidiropoulos P. , Song G. et al. TNF-alpha gene expression in macrophages: regulation by NF-kappaB is independent of c-Jun or C/EBP-beta. J Immunol 2000; 164: 4277—4285.

Fujihara M. , Wakamoto S. , Ito T. et al. Lipopolysaccharide-triggered desensitization of TNF-alpha mRNA expression involves lack of phosphorylation of I-kappa B-alpha in a murine macrophage-like cell line, P388D1. J Leukoc Biol 2000; 68: 267—276.

Wedel A. , Frankenberger M. , Sulski G. et al. Role of p52 (NF-kappaB2) in LPS tolerance in a human B cell line. Biol Chem 1999; 380: 1193—1199.

Lægreid A. , Thommesen L. , Gullstein Jahr T. et al. Tumor necrosis factor induces lipopolysaccharide tolerance in a human adenocarcinoma cell line mainly through the TNF p55 receptor. J Biol Chem 1995; 270: 25418—25425.

Sundstedt A. , Sigvardsson M. , Leanderson T. et al. In vivo anergized CD4+ T cells express perturbed AP-1 and NF-κB transcription factors. Proc Natl Acad Sci USA 1996; 93: 979—984.

Rayhane N. , Fitting C. , Cavaillon J-M. Dissociation of IFNgamma from IL-12 and IL-18 production during endotoxin tolerance. J Endotoxin Res 1999; 5: 319—324.

Kaufmann A. , Gemsa D. , Sprenger H. Differential desensitization of lipopolysaccharide-inducible chemokine gene expression in human monocytes and macrophages. Eur J Immunol 2000; 30: 1562—1567.

Heyman A. , Beeson PB Influence of various disease states upon the febrile response to intravenous injection of typhoid bacterial pyrogen. J Lab Clin Med 1949; 34: 1400—1403.

McCabe WR Endotoxin tolerance. II. Its occurrence in patients with pyelonephritis. J Clin Invest 1963; 42: 618—625.

Neva FA , Morgan HR Tolerance to the action of endotoxins of enteric bacilli in patients convalescent from typhoid and paratyphoid fevers. J Lab Clin Med 1950; 35: 911—922.

Munoz C. , Carlet J. , Fitting C. et al. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991; 88: 1747—1754.

Ertel W. , Kremer J-P. , Kenney J. et al. Down-regulation of pro-inflammatory cytokine release in whole blood from septic patients. Blood 1995; 85: 1341—1347.

Adib-Conquy M. , Adrie C. , Moine P. et al. NF-kappaB expression in mononuclear cells of septic patients resembles that observed in LPS-tolerance. Am J Respir Crit Care Med 2000; 162: 1877—1883.