Article Commentary: Encapsulated CNTF-Producing Cells for Huntington's Disease

Date I. ; Ohmoto T. ; Imaoka M. D. ; Ono T. ; Hammang J. P. ; Francis J. ; Greco C. ; Emerich D. F. Cografting with polymer-encapsulated human NGF-secreting cells enhances chromaffin cell survival and behavioral recovery in hemiparkinsonian rats. J. Neurosurg. 84: 1006–1012; 1996.

Emerich D. F. ; Winn S. R. ; Lindner M. D. ; Frydel B. R. ; Kordower J. H. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J. Neurosci. 16: 5168–5181; 1996.

Emerich D. F. ; Cain C. K. ; Greco C. ; Saydoff J. A. ; Hu Z-Y. ; Liu H. ; Lindner M. D. Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease. Cell Transplant. 6: 249–266; 1997.

Emerich D. F. ; Winn S. R. ; Lindner M. D. Continued presence of intrastriatal but not intraventricular polymer-encapsulated PC12 cells is required for alleviation of behavioral deficits in Parkinsonian rodents. Cell Transplant. 5: 589–596; 1996.

Emerich D. F. ; Bruhn S. ; Chu Y. ; Kordower J. H. Cellular delivery of CNTF but not NT4/5 prevents degeneration of striatal neurons in a rodent model of Huntington's disease. Cell Transplant. 7: 213–225; 1998.

Emerich D. F. ; Winn S. R. ; Hantraye P. M. ; Peschanski M. ; Chen E-Y. ; Chu Y. ; McDermott P. ; Baetge E. ; Kordower J. H. Protection of basal ganglia circuitry by encapsulated CNTF-producing cells in a primate model of Huntington's disease. Nature 386: 395–399; 1997.

Kordower J. H. ; Chen E-Y. ; Chu Y-P. ; McDermott P. ; Baetge E. E. ; Emerich D. F. Intrastriatal but not intraventricular grafts of encapsulated CNTF-producing cells protects against striatal degeneration in a nonhuman primate model of Huntington's disease. Soc. Neurosci. Abstr. 23; 1997.

Kordower J. H. ; Chu Y-P. ; MacLennan A. J. Ciliary neurotrophic factor receptor alpha immunoreactivity in the monkey central nervous system. J. Comp. Neurol. 377: 365–380; 1997.

Lysaght M. J. ; Aebischer P. Encapsulated cells as therapy. Sci. Am. 280: 77–82; 1999.

MacLennan J. A. ; Gaskin A. A. ; Lado D. C. CNTFR receptor alpha mRNA expression in rodent and developing rat. Mol. Brain Res. 25: 251–256; 1994.

MacLennan J. A. ; Vinson E. N. ; Marks L. ; McLaurain D. L. ; Pfiefer M. ; Lee M. Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous sytem. J. Neurosci. 16: 621–630; 1996.