Abstract
This article aims to develop a probability-based model involving the use of direct
likelihood formulation and generalised linear modelling (GLM) approaches useful in
estimating important disease parameters from longitudinal or repeated measurement
data. The current application is based on infection with respiratory syncytial virus.
The force of infection and the recovery rate or per capita loss of infection are the
parameters of interest. However, because of the limitation arising from the study
design and subsequently, the data generated only the force of infection is estimable.
The problem of dealing with time-varying disease parameters is also addressed in the
article by fitting piecewise constant parameters over time via the GLM approach. The
current model formulation is based on that published in White LJ, Buttery J, Cooper
B, Nokes DJ and Medley GF. Rotavirus within day care centres in Oxfordshire, UK:
characterization of partial immunity. Journal of Royal Society
Interface 2008;