Review : Lack of linkage between anti-nuclear antibody or clinical features of systemic lupus erythematosus (SLE) and TCR-A/Vβ loci in families of subjects with SLE

Abstract

The role of the TCR-A and TCR-Vβ genes in the genetic predisposition to SLE expression and anti nuclear antibody (ANA) production were examined by linkage analysis in eighteen multiplex and forty-three simplex SLE families. All subjects were Caucasian. A significantly increased prevalence of positive ANAs in first-degree relatives of SLE patients from multiplex families was noticed compared to that of simplex families. Linkage between TCR-A/Vβ genes and SLE expression and ANA production were analysed by affected sib-pair method. Results showed that the haplotypes identical by descent sharing TCR-A and TCR-Vβ genes in the affected sib-pairs was not different from that expected (P = 0.93 and P = 0.74, respectively). There was no linkage between ANA positivity and TCR-A and TCR-Vβ genes in ANA positive sib-pairs from both multiplex and simplex families. This study suggests that germline TCR-A and TCR-Vβ gene loci confer no susceptibility to ANA and SLE expression.

Keywords

systemic lupus erythematosus genetic susceptibility T-cell antigen receptor genes linkage analysis affects sib-pairs

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