T helper cells driving pathogenic anti-DNA autoantibody production in lupus : nucleosomal epitopes and CD40 ligand signals

Abstract

Keywords

autoimmune disease systemic lupus erythematosus T-cell receptors helper-inducer T cells co-stimulatory signals immunotherapy

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References

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Datta SK , Kaliyaperumal A. Nucleosome driven autoimmune response in lupus: Pathogenic T helper epitopes and costimulatory signals. In 'B Lymphocytes in Autoimmunity .' Ann NYAcad Sci April, 1997 (in press).

Desai-Mehta A. , Lu L. , Ramsey-Goldman R. , Datta SK Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 1996 ; 97: 2063-2073.

Kaliyaperumal A. , Mohan C. , Wu W. , Datta SK Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J Exp Med 1996; 183: 2459-2469.