MHC class II alleles and C4 deficiency alleles have been variably associated with aPL syndrome, but the extensive linkage disequilibrium among many of these alleles has made it difficult to assign a causal role for any of them. Interethnic studies of these and other alleles in large cohorts of subjects would help to clarify the roles of these alleles in aPL syndrome.
GharaviAESammaritanoLRWenJElkonKB. Induction of antiphospholipid antibodies by immunization with B2 glycoprotein I (apolipoprotein H). J Clin Invest1992; 90: 1105–1109
2.
WilsonWAFamilial anticardiolipin antibodies are associated with C4 deficiency genotypes that coexist with MHC DQB risk factors. J Rheum1994; 22: 227–235
3.
BlousseVFamily study of primary antiphospholipid syndrome (PAPS): Analysis of 29 unrelated families. Arthritis Rheum1995; 38(9): S169
4.
SmithHRAuldSLSteinRL. Familial association of antiphospholipid antibodies. Arthritis Rheum1991; 34: S42
5.
KingsmoreSFClinical and genetic factors of 12 families with an inherited primary antiphospholipid antibody syndrome. Arthritis Rheum1994; 37(9): S296
6.
GoldbergSNA family study of anticardiolipin antibodies and associated conditions. Am J Med1995; 98: 473–479
ReveilleJDNull alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematosus. Immunogenetics1985; 21: 299–311
13.
BiasWBEvidence that autoimmunity in man is a mendelian dominant trait. Am J Hum Genet1986; 39: 584–602
14.
Mackworth-YoungCGHigh incidence of anticardiolipin antibodies in relatives of patients with systemic lupus erythematosus. J Rheumatol1987; 14: 723–726
15.
MayKPWestSGMouldsJKotzinBL. Different manifestations of the antiphospholipid antibody syndrome in a family with systemic lupus erythematosus. Arthritis Rheum1993; 36: 528–533
16.
DagenaisPUrowitzMBGladmanDDNormanCD. A family study of the antiphospholipid syndrome associated with other autoimmune diseases. J Rheumatol1992; 19: 1393–1396
17.
MottaCMeyerO. Childhood-onset SLE: antiphospholipid antibodies in 37 patients and their first degree relatives. Pediatrics1993; 92: 849–853
GoldsteinBSmithCDSengarDPS. MHC class II studies of primary antiphospholipid antibody syndrome and of serum antiphospholipid antibodies in systemic lupus erythematosus. Arthritis Rheum1990; 33: S125
20.
CampsMTAssociation between HLA class II antigens and primary antiphospholipid syndrome from the South of Spain. Lupus1995; 4: 51–55
21.
Vargas-AlarconAssociation of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients. Arthritis Rheum1995; 38: 1340–1343
22.
GulkoPSAnticardiolipin antibodies in systemic lupus erythematosus: clinical correlates, HLA associations and impact on survival. J Rheum1993; 20: 1684–1693
23.
HartungKMHC gene products and anticardiolipin antibodies in systemic lupus erythematosus. Results of a multicenter study. Autoimmunity1992; 13: 95–99
24.
McHughNJMaddisonPJ. HLA-DR antigens and anticardiolipin antibodies in patients with systemic lupus erythematosus. Arthritis Rheum1989; 32: 1623–1624
25.
SaviMHLA-DR antigens and anticardiolipin antibodies in northern Italian systemic lupus erythematosus. Arthritis Rheum1988; 31: 1568–1570
26.
SebastianiGDAnticardiolipin antibodies: Their relationship with HLA-DR antigens in systemic lupus erythematosus. Br J Rheum1991; 30: 156–157
27.
McNeilHPHLA-DR antigens and anticardiolipin antibodies. Clin Exp Rheumatol1990; 8: 425–427
28.
TrabaceSHLA-DR and DQ antigens and anticardiolpiin antibodies in women with recurrent spontaneous abortions. Amer J Reprod Immunol1991; 26: 147–149
29.
CanosoRTLewisMEYunisEJ. Association of HLA-BW44 with chlorpromazine-induced autoantibodies. Clin Immunol Immunopathol1982; 25: 278–282
30.
AmertFCReveilleJD. Genetics of systemic lupus erythematosus. Rheum Dis Clin N Amer1992; 18: 865–892
31.
NepomBSNepomGT. Polyglot and polymorphism: an HLA update. Arthritis Rheum1996; 38: 1715–1721
32.
ArnettFCOlsenMLAndersonKLReveilleJD. Molecular analysis of major histocompatibility complex alleles associated with the lupus anticoagulant. J Clin Invest1991; 87: 1490–1495
33.
SchwartzHPLow protein S antigen but high protein S activity due to decreased C4b binding protein in neonates. Blood1988; 71: 562–565
34.
GinsbergJSAcquired free protein S deficiency is associated with anti-phospholipid antibodies and increased thrombin generation in patients with SLE. Am J Med1995; 98: 379–383
35.
WilsonWAPerezMCMichalskiJPArmatisPE. Cardiolipin antibodies and null alleles of C4 in black Americans with systemic lupus erythematosus. J Rheumatol1988; 15: 1768–1772
36.
BentoliaSHigh prevalence of C4 ‘null’ alleles in primary antiphospholipid syndrome. Arthritis Rheum1995; 38(9): S171
37.
PetriMWatsonRWinkelsteinJAMcLeanRH. Clinical expression of systemic lupus erythematosus in patients with C4A deficiency. Medicine1993; 72: 236–244
38.
CiteraGWilsonWA. Ethnic and geographic perspectives in SLE. Lupus1993; 2: 351–353
39.
McGregorAJLack of HLA association with anticardiolipin antibody. Brit J Rheum1990; 29: 108
40.
WilsonWA. Histocompatibility genes in antiphospholipid antibody syndrome. Lupus1996; 5: 259–262