The involvement of platelets in the antiphospholipid syndrome is complex and the full pathogenic significance is not fully understood. The binding of aPL antibodies to the platelet membrane may result in the thrombopenia and further haemostatic activation.
GalliMDaldossiMBarbuiT. Anti-glycoprotein Ib/IX and Iib/IIIa antibodies in patients with antiphospholipid antibodies. Thrombosis and haemostasis1994; 71: 571–575
2.
FabrisFSpecific antiplatelet autoantibodies in patients with antiphospholipid antibodies and thrombocytopenia. Eur J Haematol1994; 53: 232–236
ShiWAnticardiolipin antibodies block the inhibition by beta 2-glycoprotein 1 of the factor Xa generating activity of platelets. Thromb Haemost1993; 70: 342–348
5.
GalliMFinazziGBarbuiT. Thrombocytopenia in the antiphospholipid Syndrome. Brit J Haematol1996; 93: 1–5
6.
BizzaroNBrandaliseM. EDTA-dependent pseudothrombocytopenia. Association with antiplatelet and antiphospholipid antibodies. Am J Clin Pathol1995; 103: 103–107