Neurological and obstetric manifestations of the antiphospholipid syndrome

Abstract

The experience of a single centre with the neurological and obstetric complications of the antiphospholipid syndrome is presented and reviewed briefly with the general world liter ature. Both the neurologic and the obstetric manifestations exemplify the need for a greater understanding of underlying pathogenetic mechanisms and a more rigorous approach to therapy.

Keywords

phospholipid antibodies stroke pregnancy loss systemic lupus erythematosus

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References

Levine SR , Welch MA The spectrum of neurologic disease associated with antiphospholipid antibodies . Arch Neurol 1987; 44: 876-883.

Gatenby PA , Cameron K. , Shearman RP Pregnancy loss with phospholipid antibodies: Improved outcome with aspirin containing treatment. Aust NZ Obstet Gynaecol 1989; 29: 294-298.

Coull BM , Levine SR , Brey RL The role of antiphospholipid antibodies in stroke. Neurol Clin 1992; 10: 125-143.

Fulham MJ , Gatenby PA , Tuck RR Focal cerebral ischemia and antiphospholipid antibodies: a case for cardiac embolism. Acta Neurol Scand 1994; 90: 417-423.

Shi W. et al. Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. Aust NZ J Med 1990 ; 20: 231-236.

Rosove MH , Petronella MC , Brewer RN Antiphospholipid thrombosis: Clinical course after the first thrombotic event in 70 patients. Ann Intern Med 1992; 117; 303-308.

Khamashta MA et al. The management of thrombosis in the antiphospholipid antibody syndrome. N Engl J Med 1995; 332: 993-997.

Lockshin MD

Answers to the antiphospholipid antibody syndrome?

N Engl J Med 1995; 332: 1025-1027.

Harris EN et al. Thrombosis, recurrent fetal loss and thrombocytopenia. Arch Intern Med 1986; 146: 2153-2156.

10.

Khamashta MA , Asherson RA Hughes Syndrome: Antiphospholipid antibodies move closer to thrombosis in 1994. Br J Rheumatol 1995; 34: 493-497.

11.

Cowchock FS et al. Repeated fetal losses associated with antiphospholipid antibodies; A collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol 1992; 166: 1318-1323.

12.

Silver R. et al. Comparative trial of prednisone plus aspirin vs aspirin alone in the treatment of anticardiolipin antibody-positive obstetric patients. Am J Obstet Gynecol 1993; 169: 1411-1417.

13.

Silver RM et al. Clinical consequences of antiphospholipid antibodies: An historic cohort study. Obstet Gynecol 1994; 83: 372-377.