The experience of a single centre with the neurological and obstetric complications of the antiphospholipid syndrome is presented and reviewed briefly with the general world liter ature. Both the neurologic and the obstetric manifestations exemplify the need for a greater understanding of underlying pathogenetic mechanisms and a more rigorous approach to therapy.
Levine SR, Welch MAThe spectrum of neurologic disease associated with antiphospholipid antibodies . Arch Neurol1987; 44: 876-883.
2.
Gatenby PA, Cameron K., Shearman RPPregnancy loss with phospholipid antibodies: Improved outcome with aspirin containing treatment. Aust NZ Obstet Gynaecol1989; 29: 294-298.
3.
Coull BM, Levine SR, Brey RLThe role of antiphospholipid antibodies in stroke. Neurol Clin1992; 10: 125-143.
4.
Fulham MJ, Gatenby PA, Tuck RRFocal cerebral ischemia and antiphospholipid antibodies: a case for cardiac embolism. Acta Neurol Scand1994; 90: 417-423.
5.
Shi W. et al. Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population. Aust NZ J Med1990 ; 20: 231-236.
6.
Rosove MH, Petronella MC, Brewer RNAntiphospholipid thrombosis: Clinical course after the first thrombotic event in 70 patients. Ann Intern Med1992; 117; 303-308.
7.
Khamashta MA et al. The management of thrombosis in the antiphospholipid antibody syndrome. N Engl J Med1995; 332: 993-997.
8.
Lockshin MDAnswers to the antiphospholipid antibody syndrome?N Engl J Med1995; 332: 1025-1027.
9.
Harris EN et al. Thrombosis, recurrent fetal loss and thrombocytopenia. Arch Intern Med1986; 146: 2153-2156.
10.
Khamashta MA , Asherson RAHughes Syndrome: Antiphospholipid antibodies move closer to thrombosis in 1994. Br J Rheumatol1995; 34: 493-497.
11.
Cowchock FS et al. Repeated fetal losses associated with antiphospholipid antibodies; A collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol1992; 166: 1318-1323.
12.
Silver R. et al. Comparative trial of prednisone plus aspirin vs aspirin alone in the treatment of anticardiolipin antibody-positive obstetric patients. Am J Obstet Gynecol1993; 169: 1411-1417.
13.
Silver RM et al. Clinical consequences of antiphospholipid antibodies: An historic cohort study. Obstet Gynecol1994; 83: 372-377.
