We report on two patients with the primary antiphospholipid syndrome who had significant thrombocytopenia. In both patients platelet number improved soon after initiation of oral anticoagulation. Possible mechanisms for the resolution of thromboeytopenia are discussed.
Italian Registry of Antiphospholipid Antibodies (IR-APA).Thrombosis and thrombocytopenia in antiphospholipid syndrome (idiopathic and secondary to SLE): first report from the Italian Registry. Haematologica1993; 78: 313-316.
2.
Orlando E. et al. Prolonged bleeding time in patients with lupus anticoagulant . Thromb Haemost1992; 68: 495-499.
3.
Fleck RA, Rapaport SI, Rao SIAnti-prothrombin antibodies and the lupus anticoagulant. Blood1988; 72: 512-519.
4.
Asherson RA et al. The 'primary' antiphospholipid syndrome: major clinical and serological features. Medicine (Balt)1989; 68: 366-374.
5.
Rote NS et al. Immunologic detection of phosphatidylserine externalisation during thrombin-induced platelet activation. Clin Immunol Immunopathol1993; 66: 193-200.
6.
Lellouche F. et al. Imbalance of thromboxane/prostacyclin biosynthesis in patients with lupus anticoagulant. Blood1991; 11: 2894-2899.
7.
Shi W. et al. Anticardiolipin antibodies block the inhibition by β2-glycoprotein of the factor Xa generating activity of platelets. Thromb Haemost1993; 70: 342-345.
8.
Ginsberg JS et al. Increased thrombin generation and activity in patients with systemic lupus erythematosus and anticardiolipin antibodies: evidence for prothrombotic state. Blood1993; 81: 2958-2963.
9.
Shibata S. et al. Autoantibodies to heparin from patients with antiphospholipid syndrome inhibit formation of antithrombin-thrombin complexes. Blood1994; 83: 2532-2540.
10.
Yamazaki M. , Asakura H., Matsuda T.Resolution of thrombocytopenia in a patient with lupus anticoagulant who received warfarin therapy. Acta Haematol1994; 92: 52-53.
11.
Galli M., Daldossi M., Barbui T.Antiglycoprotein Ib/IX and IIb/IIIa antibodies in patients with antiphospholipid antibodies. Thromb Haemost1995; 71: 571-575.
12.
Alarcon-Segovia D., Sanchez-Guerrero J.Correction of thrombocytopenia with small dose aspirin in the primary antiphospholipid syndrome. J Rheumatol1989; 16: 1359-1361.
13.
Plantier JL et al. Evidence for a selective inhibitory effect of thrombin on megakaryocyte progenitor growth mediated by the thrombin receptor . Br J Haematol1994; 87: 755-762.
14.
Khamashta MA et al. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med1995; 332: 993-997.