Isenberg DAAnti-DNA antibodies: some enigma variations. Immunologist1994; 2: 190-193.
2.
Swaak Ajg et al. Anti-dsDNA and complement profiles as prognostic guides in SLE . Arthritis Rheum1979; 22: 226-235.
3.
Okamura M. et al. Significance of enzyme-linked immunosorbent assay (ELISA) for antibodies to double-stranded and single-stranded DNA in patients with lupus nephritis: correlation with severity of renal histology. Ann Rheum Dis1993; 52: 14-20.
4.
Brinkman K. et al. Anti-DNA antibodies and lupus nehritis: the complexity of cross-reactivity . Immunol Today1990; 11: 232-234.
5.
Raz E. et al. Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney. J Immunol1989; 142: 3076-3082.
6.
Marion TN et al. Selection of immunoglobulin variable regions in autoimmunity to DNA. Immunol Rev1992; 128: 123-149
7.
Radic MZ, Weigert M.Genetic and structural evidence for antigen selection of anti-DNA antibodies . Annu Rev Immunol1994; 12: 487-520.
8.
Stewart AK et al. VH-gene representation in autoantibodies reflects the normal human B cell repertoire. Immunol Rev1992; 128: 101-122.
9.
Elat D.The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA. Mol Immunol1990 ; 27: 203-210.
10.
Schlomchik M. et al. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med1990; 171: 265-297.
11.
Tillman DM et al. Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB-NZW)F1 mice. J Exp Med1992; 176: 761-779.
12.
Krishan MR, Marion TNStructural similarity of antibody variable regions from immune and autoimmune anti-DNA antibodies. J Immunol1993; 150: 4948-4957.
13.
Hirose S. et al. Somatic mutation diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus. Eur J Immunol1993; 23: 2813-2820.
14.
Chastagner P. et al. Clonotypic dominance and variable gene elements of pathogenic anti-DNA autoantibodies from a single patient with lupus. Scand J Immunol1994; 39: 165-178.
15.
Padlan EAOn the nature of antibody combining sites: unusual structural features that may confer on these sites an enhanced capacity for binding ligands. Proteins Struct Funct Genet1991; 11: 159-175.
16.
Radic MZ et al. Residues that mediate DNA binding of autoimmune antibodies. J Immunol1993; 150: 4966-4977.
17.
Ohnishi K. et al. Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int Immunol1994; 6: 817-830.
18.
Ehrenstein MR et al. HumanIgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int1995 (in press).
19.
Katz JB, Limpanasithikul W., Diamond B.Mutational analysis of an autoantibody: differential binding and pathogenicity . J Exp Med1994; 180: 925-932.
20.
Kalsi JK et al. Functional and structural analysis of human anti-DNA monoclonal antibodies. Arthritis Rheum1994; 37(Suppl.): S352 (Abstract No. 1145).
21.
Winkler TH, Fehr H., Kalden JRAnalysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas . Eur J Immunol1992; 22: 1719-1728.
22.
Es Jhv et al. Somatic mutations in the variable regions of human IgG anti-double stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus. J Exp Med1991; 173: 461-470.
23.
Gangemi Rmr , Singh AK, Barrett KJIndependently derived IgG anti-DNA autoantibodies from lupus-prone mouse strains express a VH gene that is not present in most murine strains. J Immunol1993; 151: 4660-4671.
24.
Mahmoudi M. et al. The role of the immunoglobulin heavy chain in human anti-DNA antibody binding specificity. Arthritis Rheum1995; 38: 389-395.
25.
Radic MZ et al. Ig H and L chain contributions to autoimmune specificities. J Immunol1991; 146: 176-182.
26.
Singh AK, Gangemi Rmr.The role of VL gene structural determinants in the fine specificity of anti-DNA antibodies. Autoimmunity1994; 18: 65-75.
27.
Diamond B., Scharff MDSomatic mutation of T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci USA1984; 81: 5841-5844.
28.
Ballard DW et al. Specificity and kinetics defining the interaction between a murine monoclonal antibody and DNA. J Biol Chem1984; 259: 3492-3598.
29.
Ballard DW, VossJr. EW. Base specificity and idiotypy of anti-DNA autoantibodies reactive with synthetic nucleic acids. J Immunol1985; 135: 3372-3380.
Braun RP, Lee JSEquilibrium binding parameters of an autoimmune monoclonal antibody specific for double-stranded DNA. J Immunol1987; 139: 175-179.
32.
Stollar BDImmunochemistry of DNA. Int Rev Immunol1989 ; 5: 1-22.
33.
Herron JN et al. An autoantibody to single-stranded DNA: comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex. Proteins Struct Funct Genet1991; 11: 159-175.
34.
Eilat D., Webster DM, Rees ARV region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice. J Immunol1988; 141: 1745-1753.
35.
Mol CD et al. Structure of an immunoglobulin Fab fragment specific for triple-stranded DNA. J Biol Chem1994; 269: 3615-3622.
36.
Mol CD et al. Structure of an immunoglobulin Fab fragment specific for poly(dG) poly(dC). J Biol Chem1994; 269: 3605-3614.
37.
Barry MM et al. Sequencing and modelling of anti-DNA immunoglobulin Fv domains: comparison with crystal structures. J Biol Chem1994; 269: 3623-2632.
38.
Smith DL, Desai AB, Johnson ADDNA bending by the A 1 and alpha-2 homeodomain proteins from yeast . Nucl Acid Res1995; 23: 1239-1243.
39.
Ivanov VI et al. CRP-DNA complexes: inducing the A-like form in the binding sites with an extended central spacer. J Mol Biol1995; 245: 228-240.
40.
Parvin JD et al. Pre-bending of a promoter sequence enhances affinity for the TATA-binding factor. Nature (Lond)1995 ; 373: 724-727.
41.
Eilat D., Anderson WFStructure-function correlates of autoantibodies to nucleic acids. Lessons from immunochemical, genetic and structural studies. Mol Immunol1994; 31: 1377-1390.
42.
Kabat EA et al. Sequences of proteins of Immunological Interest, 5th edn. US Department of Health and Human Services, 1991.
43.
Arevalo JH, Taussig MJ, Wilson IAMolecular basis for cross-reactivity and the limits of antibody-antigen complementarity . Nature1993; 365: 859-863.