Systemic lupus erythematosus and anticardiolipin antibodies in Klinefelter's syndrome

Abstract

A case report of Klinefelter's syndrome is presented that shows features of systemic lupus erythematosus, arteriographically-proven peripheral artery occlusion with leg ulcers, multiple cerebral infarcts and persistent elevations of anticardiolipin antibodies.

Keywords

Klinefelter's syndrome anticardiolipin antibodies leg ulcers β2-glycoprotein I

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References

I Price WH , Steers Ajw , Wilson J. Subarachnoid haemorrhage and Klinefelter's syndrome. Lancet 1982; 2: 380.

Monk B.

Vascular abnormality in Klinefelter's syndrome?

Lancet 1982; 2: 491.

Cohen AS et al. Preliminary criteria for the classification of systemic lupus erythematosus. Bull Rheum Dis 1971; 21: 643-648.

Matsuura E. et al. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol 1992; 148: 3885-3891.

Ortiz-Neu C, LeRoy EC. The coincidence of Klinefelter's syndrome and systemic lupus erythematosus. Arthritis Rheum 1969; 12: 241-246.

Price WH , Maclean N. , Littlewood AP SLE and Klinefelter's syndrome. Luncet 1976 ; 1: 807.

Segami MI , Alarcón-Segovia D. Systemic lupus erythematosus and Klinefelter's syndrome. Arthritis Rheum 1977; 20: 1565-1567.

French Mah , Hughes P. Systemic lupus erythematosus and Klinefelter's syndrome. Ann Rheum Dis 1983; 42: 471-473.

Sarai T. Miyawaki S. , Ofuji T. A case of Klinefelter's syndrome associated with systemic lupus erythematosus and multiple skin ulcers. Rhumachi 1977: 17: 48-55.

10.

Vogt HJ , Breit R. Ulcus cruris als Symptom eines-Klinefelter-Syndroms. Hautarzt 1969; 20: 468-469.

11.

Howell R. Hypostatic ulceration and Klinefelter's syndrome. Br Med J 1978; 2: 95-96.

12.

Durand JM et al. Lupus anticoagulant and Klinefelter's syndrome. J Rheumatol 1993; 20: 920-921.

13.

Folomeev M. , Kosheleva N. , Alekberova Z. Systemic lupus erythematosus with Klinefelter's syndrome. A case report from the USSR. J Rheumatol 1991; 18: 940 (letter).

14.

Bajocchi G. , Sandri G. , Trotta F. Anticardiolipin antibodies in Klinefelter's syndrome. J Rheumatol 1994; 21: 7 (letter).

15.

Galli M. et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990 ; 335: 1544-1547.

16.

Matsuura E. et al. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 1990; 336: 177-178.

17.

McNeil HP et al. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: β2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 1990; 87: 4120-4124.

18.

Ichikawa K. et al. β2-glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome . Arthritis Rheum 1994; 37: 1453-1461.