Ischemic optic neuropathy and high-level anticardiolipin antibodies in primary Sjögren's syndrome

Abstract

A 39-year-old woman with recurrent severe anterior ischemic optic neuropathy in the setting of Sjögren's syndrome was found to have high-titer IgM anticardiolipin antibodies (aCL) that were enhanced by the phospholipid-binding glycoprotein β₂GP1. The recognition of IgM aCL-associated vasculopathy as a possible etiologic factor in the optic neuropathy in Sjögren's syndrome may be relevant in deciding appropriate therapy.

Keywords

Antiphospholipid antibodies Sjögren's syndrome ischemic optic neuropathy

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References

Wise CM , Agudelo CA Optic neuropathy as an initial manifestation of Sjögren's syndrome. J Rheumatol 1988; 15: 799-802.

Shimode K. , Kobayashi S. , Kitani M. , Okata K.

Optic neuritis in primary Sjögren's syndrome. Clin Neuro

Neurosurg 1986; 26: 433-6.

Tesar JT , McMillan V. , Molina R. , Armstrong J. Optic neuropathy and central nervous system disease associated with primary Sjögren's syndrome. Am. J. Med 1992; 92: 686-92.

Galetta SL , Plock GL , Brucker AJ et al. Ocular thrombosis with antiphospholipid antibodies. Ann Ophthalmol 1991; 23: 207-12.

Asherson RA , Merry P. , Acheson JF , Harris EN , Hughes Grv. Antiphospholipid antibodies: a risk factor for occlusive ocular vascular disease in systemic lupus erythematosus and the 'primary' antiphospholipid antibody syndrome. Ann Rheum Dis 1989; 48: 358-61.

Asherson RA , Fei HM , Staub HL et al. Antiphospholipid antibodies and HLA associations in primary Sjögren's syndrome. Ann Rheum Dis 1992; 51: 495-8.

Levy RA , Gharavi AE , Samaritano LR , Habina L. , Quamar T. , Lockshin MD Characteristics of IgG antiphospholipid antibodies in patients with systemic lupus erythematosus and syphilis. J Rheumatol 1992; 17: 1036-40.

Gharavi AE , Samaritano LR , Wen J. et al. Characteristics of human immunodeficiency virus and chlorpromazine-induced antiphospholipid antibodies: effect of β2 glycoprotein 1 on binding to phospholipid. J Rheumatol 1994; 21: 94-9.

Vitali C. , Bombardieri S. , Moutsopoulos H. et al. Preliminary criteria for the classification of Sjögren's syndrome . Arthritis Rheum 1993; 36: 340-7.

10.

Molina R. , Provost TT , Alexander EL Peripheral inflammatory vascular disease in Sjögren's syndrome: association with nervous system complications. Arthritis Rheum 1985; 28: 1341-7.

11.

Hook EW , Marra CM Acquired syphilis in adults. N Engl J Med 1992; 326: 1060-9.

12.

Piette JC Prevention of recurrent thrombosis in the antiphospholipid syndrome. Lupus 1994; 3: 73-4.