Modelling Antibodies: Approach and Perspective

Alzari PM , Lascombe M-B. , Poljak RJ Three-dimensional structure of antibodies. Annu Rev Immunol 1988; 6: 555-80.

Darsley MJ , de la Paz P. , Phillips DC , Rees AR , Sutton BJ An approach to the study of anti-protein antibody combining sites . In: Investigation and Exploitation of Antibody Combining Sites. Reid E , Cook GMW and Morré DJ (eds). New York : Plenum Press, 1985.

Bernstein FC , Koetzle TF , Williams Gjb et al. The protein data bank: a computer-based archival file for macromelecular structures. J Mol Biol 1977; 112: 535-42.

Orengo CA , Flores TP , Taylor WR , Thornton JM Identification and classification of protein fold families. Protein Eng 1993; 6: 485-500.

De la Paz P. , Sutton BJ , Darsley MJ , Rees AR Modelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitope. EMBO J 1986; 5: 415-25.

Martin Acr. Molecular modelling of antibody combining sites. D. Phil. Thesis, University of Oxford, 1990.

Chothia C. , Lesk AM , Tramontano A. et al. Conformations of immunoglobulin hypervariable regions. Nature 1989; 342: 877-83.

Chothia C. , Lesk AM , Gherardi E. et al. Structural repertoire of the human VH segments. J Mol Biol 1992; 227: 799-817.

Fine RM , Wang H. , Shenkin PS , Yarmush DL , Levinthal C. Predicting antibody hypervariable loop conformations. II. Minimization and molecular dynamics studies of McPC603 from many randomly generated loop conformations . Proteins Struct Funct Genet 1986; 1: 342-62.

Moult J. , James Mng. An algorithm for determining the conformation of polypeptide segments in proteins by systematic search. Proteins Struct Funct Genet 1986; 1: 146-63.

Bruccoleri RE , Karplus M. Prediction of the folding of short polypeptide segments by uniform conformational sampling. Biopolymers 1987; 26: 137-68.

Martin Acr , Cheetham JC , Rees AR Modelling antibody hypervariable loops: a combined algorithm. Proc Natl Acad Sci USA 1989; 86:9268-72.

Martin Acr , Cheetham JC , Rees AR Molecular modelling of antibody combining sites. Methods Ert.Enzymol 1991; 203: 121-53.

Mas MT , Smith KC , Yarmush DL , Aisaka K. , Fine RM Modelling the anti-CEA antibody combining site by homology and conformational search. Proteins Struct Funct Genet 1992; 14.

Kabat EA , Wu TT , Perry HM , Gottesman KS , Foeller C. Sequences of Proteins of Immunological Interest, 5th edn. U.S. Department of Health and Human Services, 1991.

Schilling J. , Clevinger B. , Davie JM , Hood L. Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments. Nature 1980; 283: 35-40.

McCammon JA , Harvey SC Dynamics of Proteins and Nucleic Acids. Cambridge : Cambridge University Press, 1987 .

Darsley MJ , Rees AR Nucleotide sequences of five anti-lysozyme monoclonal antibodies. EMBO J 1985; 4: 393-8.

Jeffrey P. The Structure and Specificity of Immunoglobulins. D. Phil. Thesis , University of Oxford, 1989.

Stanfield RL , Takimotokamimura M. , Rini JM , Profy AT , Wilson IA Major antigen-induced domain rearrangements in an antibody. Structure 1993; 1: 83-93. '

Jackson T. , Morris BA , Martin Acr , Lewis Dfv , Sanders PG Molecular modelling and site-directed mutagenesis on a bovine anti-testosterone monoclonal antibody. Protein Eng 1992; 5: 343-50.