Mouse Models for the Antiphospholipid Syndrome

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Smith HR , Hansen CL , Rose R. , Canoso RT Autoimmune MRL-lpr/lpr mice are an animal model for the secondary antiphospholipid syndrome. J Rheumatol 1990 ; 17: 911-15.

Hashimoto Y. , Kawamura M. , Ichikawa K. et al. Anticardiolipin antibodies in NZW × BXSB F1 mice: a model of antiphospholipid syndrome. J Immunol 1992 ; 149: 1063-9.

Branch DW , Dudley DJ , Mitchell MD et al. Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in Balb/c mice: a model for autoimmune fetal loss. Am J Obstet Gynecol 1990; 163: 210-16.

Blank M. , Cohen J. , Toder V. , Shoenfeld Y. Induction of antiphospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal and anti-cardiolipin antibodies. Proc Natl Acad Sci USA 1991; 88: 3069-73.

Bakiner R. , Fishman P. , Blank M. et al. Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H3). J Clin Invest 1992; 89: 1558-63.

Fishman P. , Falach-Vaknine E. , Zigleman R. et al. Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo admanistration of recombinant interleukin-3. J Clin Invest 1993; 91: 1834-7.

Gharavi AE , Sammaritano LR , Wen J. , Elkon KB Induction of antiphospholipid antibodies by immunization with β2 glycoprotein I (apoliprotein H). J Clin Invest 1992; 90: 1105-9.

Pierangeli SS , Harris EN Induction of antiphospholipid binding antibodies in mice and rabbits by immunization with human β2glycoprotein I or anticardiolipin antibodies alone. Clin Exp Immunol 1993; 93: 268-72.

Blank M. , Fadin.D. , Tincani A. et al. Immunization with anticardiolipin cofactor (β2 glycoprotein I) induces experimental antiphospholipid syndrome in naive mice (submitted for publication).