The plasma levels of interleukin-4 (IL-4), interleukin-2 (IL-2), soluble receptor of IL-2 (IL-2R) and T cell expression of IL-2 receptor chain (CD25+) were determined in an attempt to relate these parameters with disease activity in systemic lupus erythematosus (SLE). IL-4, IL-2 and sIL-2R plasma levels of SLE patients were significantly higher than those of the control group (P<0.05) while CD25+ expression was similar in both groups. Only sIL-2R levels were significantly higher (P<0.05) in active than in inactive patients.
KarrayS, DefranceT, Merle-BeralH, BanchereauJ, DebreP, GalanaudP.Interleukin 4 counteracts the interleukin-2 induced proliferation of monoclonal B cells.J Exp Med1988; 168: 85–9.
3.
CroftM, SwainSL.B cell response to fresh and effector T helper cells: role of cognate T-B interaction and the cytokines IL-2, IL-4 and IL-6.J Immunol1991; 146: 4055–64.
4.
VazquezA, AuffredouMT, GalanaudP, LecaG.Modulation of IL-2 and IL-4-dependent human B cell proliferation by cyclic AMP.J Immunol1991; 148: 4222–27.
5.
ManoussakisMN, PapadopoulosGK, DrososAA, MoutsopoulosHM.Soluble interleukin-2 receptor molecules in serum of patients with autoimmune diseases.Clin Immunol Immunopathol1989; 50: 321–32.
6.
GayaA, de la CalleO, YagueJ. IL-4 inhibits IL-2 syntesis and IL-2 induced up-regulation of IL-2R but not IL-2 chain in CD4+ human T cells.J Immunol1991; 146: 4209–14.
7.
TanEM, CohenAS, FriesJ. The 1982 revised criteria for the classification of systemic lupus erythematosus.Arthritis Rheum1982; 25: 1277–87.
8.
LiangMH, SternS, EsdaileJ.Systemic lupus erythematosus activity: an operational definition.Rheum Dis Clin North Am1988; 14: 57–66.
9.
HuangYP, PerrinLH, MiescherPA, ZublerRA.Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus.J Immunol1988; 141: 827–33.
10.
Alcocer VarelaJ, Alarcon-SegoviaD.Decreased production of a response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.J Clin Invest1982; 69: 1388–92.
11.
Linker-IsraeliM, QuismorioFP, HorwitzDA.Further characterization of interleukin-2 production of patients with systemic lupus erythematosus.J Rheumatol1988; 15: 1216–22.
12.
MckennaRM, WilkinsJA, WarringtonRI.Lymphokine production in rheumatoid arthritis and systemic lupus erythematosus.J Rheumatol1988; 15: 1639–42.
13.
SantamariaM, MarubayashiM, Garcia-CozarF, CuadradoMJ, Fernandez-ArcasN, PenaJ.11-2 production via CD28 is conserved in SLE T cells (submitted for publication).
14.
DraegerAM, SwaakAJ, Van-den-BkinkHg, AardenLA.T cell function in SLE: normal production of a responsiveness to interleukin-2.Clin Exp Immunol1986; 64: 80–7.
15.
HuangYP, MiescherPA, ZublerRH.The interleukin-2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells.J Immunol1986; 137: 3515–20.
16.
RazziudinS, Al JanadiMA, WabellAA.Soluble IL-2 receptor levels in serum and its relationship to T cell abnormality and clinical manifestations of the disease in patients with SLE.J Rheumatol1991; 18: 831–6.
17.
CampenDH, HorwitzDA, QuismorioFP. Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by system immune activation.Arthritis Rheum1990; 31: 1358–64.
18.
DegiannisD, SeiboldJ, CzarneckiM, RaskovaJ, RaskaK.Soluble IL-2R in patients with systemic sclerosis.Arthritis Rheum1990; 33: 375–80.
19.
IshidaH, KumagaiS, UmeharaH. Impaired expression of high affinity IL-2R on activated lymphocites from patients with SLE.J Immunol1987; 139: 1070–74.
20.
InghiramiG, SimonJ, BallowJE, TsokosGC.Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin.Clin Exp Rheumatol1988; 6: 269–76.
21.
BloemenaE, van OersMH, WeinreichS, SchellekensPT.Cyclosporine A and prednisolone do not inhibit the expression of high-affinity receptors for IL-2.Clin Exp Immunol1988; 71: 308–13.
22.
Martinez-CorderoE, VarelaAlcocer, Alarcon SegoviaD.Stimulating and differentiation factors for human B lymphocytes in SLE.Clin Exp Immunol1986; 65: 598–604.
23.
UedaY, SakaneT, TsumematsuT.Hyperreactivity of activated B cells to B cell growth factor in patients with systemic lupus erythematosus.J Immunol1989; xx: 3988–93.