Clinical observations and experimental data suggest that sex hormones influence the develop ment of systemic lupus erythematosus (SLE). An imbalance between androgen and estrogen plasma levels may suggest an abnormality in the aromatase activity involved in estradiol syn thesis. Aromatase activity in skin and subcutaneous tissue and plasma sex-hormone levels (testosterone, androstenedione, estrone, estradiol, dehydrosterone sulfate, cortisol) were measured in 15 SLE patients (nine female, six male) who had never received corticosteroid treatment and in eight (four female, four male) healthy control subjects. There was a tendency toward an increase in aromatase activity in SLE patients when compared to control subjects. Among SLE patients the aromatase activity varied inversely with disease activity. Patients with SLE had decreased androgen and increased estrogen levels. Aromatase activity in SLE patients had significant direct correlation with estrogen levels. These data suggest that abnormal regulation of aromatase activity may partially explain the abnormalities of estrogen synthesis in SLE.
Jungers P., Dougados M., Pelissier C. et al. Influence of oral contraceptive therapy on the activity of systemic lupus erythematosus. Arthritis Rheum1982; 24: 618-22.
10.
Stern R., Fishman J., Brusman H., Kunkel H.Systemic lupus erythematosus associated with Klinefelter's syndrome . Arthritis Rheum1977; 20: 18-20.
11.
Folomeev M. , Kosheleva N., Alekberova Z.Systemic lupus erythematosus associated with Klinefelter's syndrome—a case report from the USSR. J Rheumatol1991; 18: 940-1.
Roubinian JR , Talal N., Siiteri PK, Sadakian JASex hormone modulation of autoimmunity in NZB/W mice. Arthritis Rheum1979; 22: 1163-9.
14.
Inman RD, Javonovac L., Markenson JA et al. Systemic lupus erythematosus in men. Genetic and endocrine features . Arch Int Med1982; 144: 1813-20.
15.
Lahita RGSex and age in systemic lupus erythematosus. In: Lahita RG, ed. Systemic Lupus Erythematosus . New York: John Wiley & Sons Inc., 1987: 523-40.
16.
Jungers P., Nahoul K., Pelissier C. et al. Low plasma androgens in women with active or quiescent systemic lupus erythematosus. Arthritis Rheum1982; 25: 454-7.
17.
Morley K., Parke A., Hughes G.Systemic lupus erythematosus: two patients treated with danasol. Br Med J1982; 284: 1431-5.
18.
Folomeev M. , Polyntsev Yu.Androgens in combined treatment of men with systemic lupus erythematosus. Reumatologia1986; 4: 24-7.
19.
Grodin GM, Siiteri PK, MacDonald PCSource of estrogen production in postmenopausal women. J Clin Endocrinol Metabol1973; 36: 207-9.
20.
Longcope C.Methods and results of aromatization studies in vivo. Cancer Res1982; 42 (Suppl.): 3307-11S.
21.
Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum1982; 25: 1271-7.
22.
Bombardier C. , Chang CH, Gladman D., Urowitz M., Committee on Prognosis Study in SLE. Development of the SLE disease activity index: SLE DAI. (in preparation)
23.
Thompson E. , Siiteri PKUtilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstanedione. J Biol Chem1974; 249: 5364.
24.
Weisz J., Brown B., Ward I.Maternal stress decreases steroid aromatase activity in brains of male and female rat fetus. Neuro-endocrinology1982 ; 35: 374-9.
25.
Roger M., Nahoul K., Taublane JE, Castanier M., Canlorbe P., Job JCLes androgens plasmatiques chez le garçon de la naissance à l'adolescence. AnnPediatr1979; 26: 239-45.
26.
Murphy Bep, Diez D'Aux RC. The use of Sephadex LH-20 column chromatography to separate unconjugated steroids. J Steroid Biochem1975 ; 6: 233-7.
27.
Snedecor BW, Cochran WGStatistical Methods. Ames: Iowa State University Press, 1974.
28.
Pratt J., Longcope C.Effect of adrenocorticotrophin on production rates and metabolic clearance rates of testosterone and estradiol. J Clin Endocrinol Metabol1978; 47: 307-11.
29.
Sakakura M. , Takebe K., Nakagawa S.Inhibition of LH secretion induced by synthetic LRH by long term treatment with glucocorticoids in human subjects. J Clin Endocrinol Metabol1975; 40: 777-80.
30.
Woof P., Hamill R., McDonald J. et al. Transient hypogonadotropic hypogonadism caused by critical illness . J Clin Endocrinol Metabol1985; 60: 444-9.
31.
Warner B., Dufan M., Santen R.Effects of aging and illness on the pituitary testicular axis in men: quantitative as well as qualitative changes in LH. J Clin Endocrinol Metabol1985; 60: 263.
32.
Mason J., Kenion C., Collins D. et al. Urinary testosterone response in 72-hr to avoidance sessions in monkey. Psychosomatic Med1968 ; XXX: 721-9.
33.
Folomeev M.Systemic lupus erythematosus in males. Dissertation. Moscow : Institute of Rheumatology, 1984 , 147pp.
