Sex Steroids and SLE: Metabolism of Androgens to Estrogens

Lahita RG , Bradlow HL , Kunkel HG , Fishman J. Increased 16 alpha hydroxylation of estradiol in systemic lupus erythematosus . J Clin Endo Metab 1981; 53: 174-8.

Lahita RG , Bradlow HL , Kunkel HG , Fishman J. Alterations of estrogen metabolism in SLE. Arthritis Rheum 1979; 22: 1195-8.

Lahita RG Sex steroids and the rheumatic diseases. Arthritis Rheum 1985; 28: 121-6.

Ahmed SA , Dauphinee M. , Talal N. Effects of short term administration of sex hormones on normal and autoimmune mice. J Immunol 1985; 134: 204-10.

Fishman J. , Martucci C. Biological properties of 16-alpha hydroxyestrone: implications in estrogen physiology and pathophysiology. J Clin Endo Metab 1980; 51: 611.

Snow RC , Barbieri RI , Frisch R. Estrogen 2-hydroxylase oxidation and menstrual function among elite oarswomen . J Clin Endo Metab 1989; 69: 369-76.

Lahita RG , Bradlow HL , Kunkel HG , Fishman J. Increased oxidation of testosterone in systemic lupus erythematosus . Arthritis Rheum 1983; 26: 1517-21.

Lahita RG , Bradlow HL Klinefelter's syndrome: hormone metabolism in hypogonadal males with systemic lupus erythematosus. J Rheumatol 1987; 14 (Suppl 13): 154-7.

Bizarro A. , Valentini G. , DiMartino G, Daponte A. , Debillis A. , Iacono G. Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome. J Clin Endo Metab 1987; 64: 32-6.

Sthoeger ZM , Chiorazzi N. , Lahita RG Regulation of the immune response by sex hormones. I. In vivo effects of estradiol and testosterone on pokeweed mitogen-induced B-cell differentiation. J Immunol 1988; 141: 9i.

Lavalle C. , Loyo E. , Paniagua R. et al. Correlation study between prolactin and androgens in male patients with systemic lupus erythematosus. J Rheumatol 1987; 14: 268-72.

Jara-Quezada L. , Graef A. , Lavalle C. Prolactin and gonadal hormones during pregnancy in systemic lupus erythematosus. J Rheumatol 1991; 18: 349-53.

Bucala R. , Fishman J. , Cerami A. The reaction of 16-α hydroxyestrone with erythrocytes in vitro and in vivo. Eur J Biochem 1984; 140: 593-8.

Bucala R. , Lahita RG , Fishman J. , Cerami A. Nonenzymatic modification of red cell and lymphocyte membrane proteins by 16-alpha hydroxyestrone in patients with systemic lupus erythematosus. Arthritis Rheum 1984; 27: s40 (abstract).

Bucala R. , Fishman J. , Cerami A. Formation of co-valent adducts between cortisol and 16-alpha-hydroxyestrone and protein, possible role in pathogenesis of cortisol toxicity and SLE. Proc Nat Acad Sci USA 1982; 79: 3320.

Danel L. , Sovweine G. , Monier JC , Saez S. Specific estrogen binding sites in human lymphoid cells and thymic cells. J Steroid Biochem 1983; 18: 559.

Cohen Jhm , Danel L. , Cordier G. , Saez S. , Revillard J. Sex steroid receptors in peripheral T cells: absence of androgen receptors and restriction of estrogen receptors to OKT8 positive cells. J Immunol 1983; 131: 2767-71 (abstract).

Drayer D. , Lorenzo B. , Lahita RG , Robbins W. , Reidenberg MM Microsomal hydroxylation as measured by pentobarbital elimination in patients with idiopathic systemic lupus erythematosus. Clin Pharm Therap 1982; 32: 195-200.

Tsoulis CJ , Hobkirk R. Factors affecting the 16 alpha-hydroxylation of estrone 3-sulfate by guinea pig liver microsomes. Can J Biochem 1981; 59: 454-60.

Emoto N. , Baird A. The effect of tumor necrosis factor/cachectin on follicle stimulating hormone-induced aromatase activity in cultured rat granulosa cells. BBRC 1988; 153: 792-8.

Lahita RG , Cheng CY , Monder C. , Bardin CW Experience with 19-nortestosterone in the therapy of systemic lupus erythematosus: worsened disease after treatment with 19-nortestosterone in men and lack of improvement in women. J Rheumatol 1992 (in press).