Abstract
A 40-year-old woman presented with new-onset heart failure with reduced ejection fraction (HFrEF) accompanied with systemic symptoms, including arthralgia, cutaneous lesions, and Raynaud’s phenomenon. Initial investigation led to the diagnosis of systemic lupus erythematosus (SLE), with subsequent finding of dilated cardiomyopathy, a rare but severe secondary manifestation of SLE. Early recognition and appropriate management of underlying autoimmune conditions can lead to substantial improvement in cardiac function, emphasizing the need for comprehensive evaluation in patients with de novo heart failure and systemic symptoms.
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