A dysregulated immune response plays a critical role in systemic lupus erythematosus (SLE) pathogenesis. Environmental factors such as viruses, including coronavirus 2 (COVID-19), have been described to play a role in SLE presentation and exacerbation. These viruses trigger a host’s humoral and cellular immunities typically essential in elimination of the viral infection. We present a case of a Hispanic male who developed new-onset lupus nephritis class II after a COVID-19 infection.
Pons-EstelGJAlarcónGSScofieldL, et al.Understanding the epidemiology and progression of systemic lupus erythematosus. Semin Arthritis Rheum2010; 39(4): 257–268.
2.
BernatskySBoivinJFJosephL, et al.Mortality in systemic lupus erythematosus. Arthritis Rheum. 2006; 54(8): 2550–2557.
3.
DayalNAIsenbergDA. SLE/myositis overlap: are the manifestations of SLE different in overlap disease?Lupus2002; 11(5): 293–298.
4.
BrewerBNKamenDL. Gastrointestinal and hepatic disease in systemic lupus erythematosus. Rheum Dis Clin North Am2018; 44(1): 165–175.
5.
DrenkardCVillaARReyesE, et al.Vasculitis in systemic lupus erythematosus. Lupus1997; 6(3): 235–242.
6.
SmattiMKCyprianFSNasrallahGK, et al.Viruses and autoimmunity: a review on the potential interaction and molecular mechanisms. Viruses2019; 11(8): 762. doi: 10.3390/v11080762.
7.
JooYBKimKJParkKS, et al.Influenza infection as a trigger for systemic lupus erythematosus flares resulting in hospitalization. Sci Rep2021; 11(1): 4630. doi: 10.1038/s41598-021-84153-5.
8.
Mantovani CardosoEHundalJFetermanD, et al.Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology. Clin Rheumatol2020; 39(9): 2811–2815.
9.
SlimaniYAbbassiREl FatoikiFZ, et al.Systemic lupus erythematosus and varicella-like rash following COVID-19 in a previously healthy patient. J Med Virol2020; 93(2): 1184–1187. doi: 10.1002/jmv.26513.
10.
ZamaniBMoeini TabaSMShayestehpourM. Systemic lupus erythematosus manifestation following COVID-19: a case report. J Med Case Rep2021; 15(1): 29. doi:10.1186/s13256-020-02582-8
11.
BonomettiRSacchiMCStobbioneP, et al.The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection. Eur Rev Med Pharmacol Sci2020; 24(18): 9695–9697. doi: 10.26355/eurrev_202009_23060
12.
KudoseSBatalISantorielloD, et al.Kidney biopsy findings in patients with COVID-19. J Am Soc Nephrol. 2020;31(9):1959–1968. doi: 10.1681/ASN.2020060802.
13.
RodríguezYNovelliLRojasM, et al.Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. J Autoimmun2020; 114: 102506. doi:10.1016/j.jaut.2020.102506
