Abstract
Background
The coexistence of psoriasis and cutaneous lupus erythematosus (LE) is uncommon. Treatment for concomitant psoriasis and LE is challenging because some valid treatments for LE such as hydroxychloroquine and systemic corticosteroid are known to aggravate psoriasis. Th17 pathway is shared by these two disease entities. Thus, biologics targeting Th17 pathway, including ustekinumab and secukinumab, have been successfully used in the treatment of patients with concomitant psoriasis and LE.
Purpose
We report a patient with aggravation of discoid lupus erythematosus (DLE) after secukinumab treatment for psoriasis.
Reseach design
Case report.
Study sample
One patient was included in this case report.
Data collection and analysis
Clinical and pathological pictures were presented after informed consent.
Result
Symptoms of psoriasis and psoriatic arthritis almost resolved after 150 mg secukinumab every four weeks for 2 years, but lesions of DLE enlarged and became generalized.
Conclusion
LE is a highly heterogeneous disease, and further studies are required to find the optimal treatment in patients suffering from both LE and psoriasis.
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