Restricted accessCase reportFirst published online 2017-10
Development of primary central nervous system lymphoma in a systemic lupus erythematosus patient after treatment with mycophenolate mofetil and review of the literature
Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma and four cases of PCNSL have previously been described in association with mycophenolate mofetil. We report the fifth case of PCNSL in a patient with lupus nephropathy while on mycophenolate mofetil treatment.
EkstromSmedbyKVajdicCMFalsterMet al.Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood2008; 111: 4029–4038.
2.
BernatskySRamsey-GoldmanRLabrecqueJet al.Cancer risk in systemic lupus: an updated international multi-centre cohort study. J Autoimmun2013; 42: 130–135.
3.
LofstromBBacklinCSundstromCEkbomALundbergIE. A closer look at non-Hodgkin's lymphoma cases in a national Swedish systemic lupus erythematosus cohort: a nested case–control study. Ann Rheum Dis2007; 66: 1627–1632.
4.
DasguptaNGelberACRackeFFineDM. Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis. Lupus2005; 14: 910–913.
5.
FinelliPFNaikKDiGiuseppeJAPrasadA. Primary lymphoma of CNS, mycophenolate mofetil and lupus. Lupus2006; 15: 886–888.
6.
TsangHHTrendell-SmithNJWuAKMokMY. Diffuse large B-cell lymphoma of the central nervous system in mycophenolate mofetil-treated patients with systemic lupus erythematosus. Lupus2010; 19: 330–333.
7.
LaiGGKooYXTaoMTanTTLimST. Use of rituximab in combination with high-dose methotrexate in the treatment of primary central nervous system lymphoma in a mycophenolate mofetil treated patient with lupus nephritis. Acta Oncol2011; 50: 144–145.