Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease of unknown etiology that most frequently involves the skin and the musculoskeletal system. In addition to the more common cutaneous manifestations, interstitial granulomatous dermatitis (IGD) may rarely occur in association with SLE or even be the first sign of the disease. We describe a 40-year-old man with SLE-associated IGD, and review all cases of SLE-associated IGD in the literature.
HochbergMC. Updating the American College of Rheumatology Revised criteria for the classification of systemic lupus erythematosus. Arth Rheum1997; 40: 1725–1725.
2.
TomasiniCPippioneM. Interstitial granulomatous dermatitis with plaques. J Am Acad Dermatol2002; 46: 892–899.
3.
DubeySMerryP. Clinical vignette. Interstitial granulomatous dermatitis (Ackerman's syndrome) in SLE presenting with the ‘rope sign'. Rheumatology (Oxford)2007; 46: 80–80.
4.
BlaiseSSalameireDCarpentierPH. Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus?Clin Exp Dermatol2008; 33: 712–714.
5.
García-RabascoAEsteve-MartínezAZaragoza-NinetVSánchez-CarazoJLAlegre-de-MiquelV. Interstitial granulomatous dermatitis in a patient with lupus erythematosus. Am J Dermatopathol2011; 33: 871–872.
6.
GuerinMHaettichBBaraC. Lupus attributable to anti-TNF therapy and revealed by interstitial granulomatous dermatitis. Rheumatol Int2012; 32: 2937–2940.
WongHKKaffenbergerBHZirwasM. A palpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. Interstitial granulomatous dermatitis (IGD). JAMA Dermatol2013; 149: 609–614.
9.
AckermanABHistologic diagnosis of inflammatory skin diseases: interstitial granulomatous dermatitis with arthritis. In: AckermanABGuoYVitalePPatriciaA (eds). Clues to diagnosis in dermatopathology, Vol. 3, 1st ed. Chicago, IL: ASCP Press, 1993, pp. 309–312.
10.
PeroniAColatoCSchenaDGisondiPGirolomoniG. Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. Br J Dermatol2012; 166: 775–783.
11.
LongDThiboutotDMMajeskiJT. Interstitial granulomatous dermatitis with arthritis. J Am Acad Dermatol1996; 34: 957–961.
12.
AltaykanAErkinGBotzepeGGöközA. Interstitial granulomatous dermatitis with arthritis. Hum Pathol2004; 35: 892–894.
VerneuilLDompmartinAComozF. Interstitial granulomatous dermatitis with cutaneous cords and arthritis: a disorder associated with autoantibodies. J Am Acad Dermatol2001; 45: 286–291.
18.
ChenDLChongAHGreenJ. A novel case of polyfibromatosis and interstitial granulomatous dermatitis with arthritis. J Am Acad Dermatol2006; 55: S32–37.
19.
ComteCGuillotBDurandL. Dermatite granulomateuse interstitielle avec arthritis: quatre cas. Ann Dermatol Venereol2008; 135: 38–43.
20.
AloiFTomasiniCPippioneM. Interstitial granulomatous dermatitis with claque. Am J Dermatopathol1999; 21: 320–323.
21.
KroesenSItinPHHaslerP. Arthritis and interstitial granulomatous dermatitis (Ackerman syndrome) with pulmonary silicosis. Semin Arthritis Rheum2003; 32: 334–340.
22.
SchreckenbergCAschPHSibiliaJ. Dermatite granulomateuse interstitielle et polyarthrite rheumatoide paraneoplasiques revelatrices d’un cancer du poumon. Ann Dermatol Venereol1998; 125: 585–588.
BassasJUmbertP. Dermatitis granulomatosa intersticial con arthritis. Actas Dermosifilogr2004; 95: 120–123.
33.
SiamiKWilkersonMClarkSHCrowsonAN. Pathologic quiz case: an indurated plaque on the ankle of a 74-year-old woman. Interstitial granulomatous drug reaction. Arch Pathol Lab Med2004; 128: e129–130.
LeeHWChangSELeeMW. Interstitial granulomatous dermatitis with plaques associated with antiphospholipid syndrome. Br J Dermatol2005; 152: 814–816.
36.
ChanAYKTangWYMLamWY. Interstitial granulomatous dermatitis presenting as erythematous plaque over both ankles. Hong Kong J Dermatol Venereol2006; 14: 199–202.
Moon HR, Lee JH, Won CH, et al. A child with interstitial granulomatous dermatitis and juvenile idiopathic arthritis. Pediatr Dermatol 2013; 30: e272–e273.
39.
LeloupPAubertHCausseSLe GoffBBarbarotS. Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. JAMA Dermatol2013; 149: 626–627.
40.
WorsnopFSOstlereL. Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. Clin Exp Dermatol2013; 38: 564–565.
41.
AntunesJPachecoDTravassosARSoares-AlmeidaLMFilipePSacramento-MarquesM. Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis. An Bras Dermatol2012; 87: 748–751.
AlghamdiRBejarCSteffM. Intravenous immunoglobulins as a treatment of interstitial granulomatous dermatitis with arthritis. Br J Dermatol2012; 167: 218–220.
44.
SchanzSSchmalzingMGuenovaE. Interstitial granulomatous dermatitis with arthritis responding to tocilizumab. Arch Dermatol2012; 148: 17–20.
45.
PatsatsiAKyriakouATriantafyllidouESotiriadisD. Interstitial granulomatous dermatitis: another clinical variant. Case Rep Dermatol2011; 3: 195–200.
46.
GüneşPGöktayFMansurATKökerFErfanG. Collagen–elastic tissue changes and vascular involvement in granuloma annulare: a review of 35 cases. J Cutan Pathol2009; 36: 838–844.
47.
ChuPConnollyMKLeBoitPE. The histopathologic spectrum of palisade neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol1994; 130: 1278–1283.
48.
GermanasJPMehrabiDCarderKR. Palisaded neutrophilic granulomatous dermatitis in a 12-year-old girl with systemic lupus erythematosus. J Am Acad Dermatol2006; 55: S60–62.
49.
MisagoNInoueHInoueTNagasawaKNarisawaY. Palisaded neutrophilic granulomatous dermatitis in systemic lupus erythematosus with a butterfly rash-like lesion. Eur J Dermatol2010; 20: 128–129.
50.
MagroCMCrowsonANSchapiroBL. The interstitial granulomatous drug reaction: a distinctive clinical and pathological entity. J Cutan Pathol1998; 25: 72–78.
