Kikuchi–Fujimoto’s disease (KFD), or histiocytic necrotizing lymphadenitis, is a benign and self-limiting disease of unknown aetiology. KFD tends to affect a young population under 30 years of age and predominantly females. KFD is a rare pathology and its association with systemic lupus erythematosus (SLE) is not frequent. Herein, we present the case of a male Italian patient with SLE in association with KFD with 5 years of follow-up, where a differential diagnosis from infection or lymphoproliferative disease was problematic.
SantanaALessaBGalraoLLimaISantiagoM. Kikuchi–Fujimoto's disease associated with systemic lupus erythematosus: Case report and review of the literature. Clin Rheumatol2005; 24: 60–63.
2.
PatraABhattacharyaSK. SLE developing in a follow-up patient of Kikuchi’s disease: A rare disorder. J Clin Diagn Res2013; 7: 752–753.
3.
PrimroseWJNapierSSPrimroseAJ. Kikuchi–Fujimoto disease (cervical subacute necrotising lymphadenitis): An important benign disease often masquerading as lymphoma. Ulster Med J2009; 78: 134–136.
4.
ZuoYFoshatMQianYWKellyBHarperBKarnathB. A rare case of Kikuchi Fujimoto's disease with subsequent development of systemic lupus erythematosus. Case Rep Rheumatol2012. [Epub 2012 Dec 30].
5.
TanEMCohenASFriesJF. The 1982 revised criteria for the classification of systemic lupus erythematous (SLE). Arthritis Rheum1982; 25: 1271–1277.
6.
PetriMMagderL. Classification criteria for systemic lupus erythematosus: A review. Lupus2004; 13: 829–837.
7.
TanakaTOhmoriMYasunagaSOhshimaKKikuchiMSasazukiT. DNA typing of HLA class II genes (HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi’s disease). Tissue Antigens1999; 54: 246–253.
VilaLMMayorAMSilvestriniIE. Therapeutic response and long-term follow-up in a systemic lupus erythematosus patient presenting with Kikuchi's disease. Lupus2001; 10: 126–128.
16.
NorrisAHKrasinskasAMSalhanyKEGluckmanSJ. Kikuchi–Fujimoto disease: A benign cause of fever and lymphadenopathy. Am J Med1996; 101: 401–405.
17.
KwonSYKimTKKimYSLeeKYLeeNJSeolHY. CT findings in Kikuchi disease: Analysis of 96 cases. AJNR Am J Neuroradiol2004; 25: 1099–1102.
18.
SagitMAkınIElvericiBOYurdakulC. An unusual cause of cervical lymphadenopathies. Neth J Med2008; 66: 262–263.
19.
Diez-MorrondoCPantoja-ZarzaLManjón-HacesJA. Kikuchi Fujimoto’s disease appearing as systemic lupus erythematosus. Inicio de lupus eritematoso sistémico como enfermedad de Kikuchi-Fujimoto. Reumatol Clin2012; 8: 153–155.
20.
GoldblattFAndrewsJRussellAIsenbergD. Association of Kikuchi–Fujimoto's disease with SLE. Rheumatology (Oxford)2008; 47: 553–555.
21.
KimSKKangMSYoonBY. Histiocytic necrotizing lymphadenitis in the context of systemic lupus erythematosus (SLE): Is histiocytic necrotizing in SLE associated with skin lesion?Lupus2011; 20: 809–819.
22.
VeerVLimAIssingW. Kikuchi–Fujimoto disease: A case report and literature review. Case Report Otolaryngol2012; 2012: 497604–497604.
