Lupus associated protein loosing enteropathy (LUPLE) is a rare gastrointestinal manifestation of SLE. We presented a case of painless ascites from serve hypoalbuminaemia secondary to LUPLE. The patient responded to a course of intravenous cyclophosphamide. The remission was maintained by azathioprine and low dose prednisolone.
UmarSBDiBaiseJK. Protein-losing enteropathy: Case illustrations and clinical review. Am J Gastroenterol2010; 105: 43–49; quiz 50.
2.
SultanSMIoannouYIsenbergDA. A review of gastrointestinal manifestations of systemic lupus erythematosus. Rheumatology (Oxford)1999; 38: 917–932.
3.
MokCCYingKYMakAToCHSzetoML. Outcome of protein-losing gastroenteropathy in systemic lupus erythematosus treated with prednisolone and azathioprine. Rheumatology (Oxford)2006; 45: 425–429.
TsutsumiASugiyamaTMatsumuraR. Protein losing enteropathy associated with collagen diseases. Ann Rheum Dis1991; 50: 178–181.
6.
WoodMLFouldsISFrenchMA. Protein losing enteropathy due to systemic lupus erythematosus. Gut1984; 25: 1013–1015.
7.
ChngHHTanBETehCLLianTY. Major gastrointestinal manifestations in lupus patients in Asia: Lupus enteritis, intestinal pseudo-obstruction, and protein-losing gastroenteropathy. Lupus2010; 19: 1404–1413.
8.
Forouhar-GraffHDennis-YawinguKParkeA. Insidious onset of massive painless ascites as initial manifestation of systemic lupus erythematosus. Lupus2011; 20: 754–757.
9.
ZhengWJTianXPLiL. Protein-losing enteropathy in systemic lupus erythematosus: Analysis of the clinical features of fifteen patients. J Clin Rheumatol2007; 13: 313–316.
10.
BastRCJrFeeneyMLazarusHNadlerLMColvinRBKnappRC. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest1981; 68: 1331–1337.
11.
DaoudEBodorG. CA-125 concentrations in malignant and nonmalignant disease. Clin Chem1991; 37: 1968–1974.
12.
SzekaneczESzucsGSzekaneczZ. Tumor-associated antigens in systemic sclerosis and systemic lupus erythematosus: Associations with organ manifestations, immunolaboratory markers and disease activity indices. J Autoimmun2008; 31: 372–376.
13.
MoncayoRMoncayoHE. A new endocrinological and immunological syndrome in SLE: Elevation of human chorionic gonadotropin and of antibodies directed against ovary and endometrium antigens. Lupus1995; 4: 39–45.
14.
DalviSYildirimRSantorielloDBelmontH. Pseudo-pseudo Meigs' syndrome in a patient with systemic lupus erythematosus. Lupus2012; 21: 1463–1466.
15.
YangZLiangYLiCZhongR. Serum CA125 elevation is independently associated with serositis in SLE patients. Clin Exper Rheumatol2012; 30: 93–98.
YaziciYErkanDLevineDMParkerTSLockshinMD. Protein-losing enteropathy in systemic lupus erythematosus: Report of a severe, persistent case and review of pathophysiology. Lupus2002; 11: 119–123.
18.
Werner de CastroGRAppenzellerSBertoloMBCostallatLT. Protein-losing enteropathy associated with systemic lupus erythematosus: Response to cyclophosphamide. Rheumatol Int2005; 25: 135–138.
